DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axud1 and Csrnp1

DIOPT Version :9

Sequence 1:	NP_001259928.1	Gene:	Axud1 / 33419	FlyBaseID:	FBgn0261647	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_038937740.1	Gene:	Csrnp1 / 363165	RGDID:	1305999	Length:	673	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	191/634 - (30%)
Similarity:	266/634 - (41%)	Gaps:	142/634 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 LWLKLNNETEMATRSAEVVSNNQASLEPAQPA-----KPKEDEL-RDGGSDSGLGSETSALLKDQ 249
            ||     ..:.|.....|:|    .|||..|.     |.|.|:| .|..|.|.|.|  ..|....
  Rat    70 LW-----RLQKALHRPSVLS----CLEPLHPTMAGIQKRKFDQLEEDDCSSSSLSS--GDLSPSP 123

  Fly   250 AEKEAEPEIQKKVE---TKPIRSNLKRRLEDSESDAIDLVPDMSAPPVAPQKRTKRSINFDEVKV 311
            ....|.|....:.|   .:|.:       .|.:|..|..:...|....||::|... :.||.:.|
  Rat   124 PSSSASPAWTSEEEGLGDQPPQ-------PDQDSSGIQSLMPPSILKRAPRERPGH-VAFDGITV 180

  Fly   312 FYFPRQQGFSCVPTAGGCTLGMGARHVGFKTMTLAEHAAELRRAHRS------QNQELQ------ 364
            :||||.|||:.||:.|||||||.:||...:..:|||...|..||.|.      :.::|:
  Rat   181 YYFPRCQGFTSVPSHGGCTLGMASRHSTCRLFSLAEFKQEQFRARREKLRRRLKEEKLEMLKWKL 245

  Fly   365 ------------PRGSSSDDSEESEEDYLSEGSGSDAEDGSNGFLQPVTPKQRRALLKAAGVRKI 417
                        |....:.|....|||.....:|...|:.:  ||||..|:||||||:|:|||:|
  Rat   246 SVSGVPEAGADVPLTVDAIDDASVEEDLAVAVAGGRLEEAN--FLQPYPPRQRRALLRASGVRRI 308

  Fly   418 DASEKSECRDIRNSREVCGCSCREFCDPETCACSQAGIKCQVDRAMFPCGCTREACGNTVGRVEF 482
            |..||.|.:.:|.|||.|||.|...||||||:|..||||||:|...|||||..|.|.|..|||||
  Rat   309 DREEKRELQALRQSREDCGCHCDGVCDPETCSCILAGIKCQMDHTSFPCGCCSEGCENPHGRVEF 373

  Fly   483 NPTRVRTHYIHTVMRLDLEQRQGSVQGVQGGHLQPQQQQPSQQTIGYSPVGTAGSTSAYFL---- 543
            |..||:||:|||:.||.:||...|:    |....|.:..|.:||: .||...:..|.:..|
  Rat   374 NQARVQTHFIHTLTRLQMEQGAESL----GDPESPMEDVPVEQTV-VSPFPPSKPTMSNDLGDSS 433

  Fly   544 ------QTQSNYSSGYASPAYTPESSVSYYQQQVQQPGVPTAG-----------QLIPQQQ---- 587
                  .:.:.||||       ...|.|.....:..|.:|.:.           |::....
  Rat   434 CGSDMTDSSTTYSSG-------GSGSRSEAPNHLAHPSLPGSSFRSGIDEDSLEQILNFSDSDLG 491

  Fly   588 -QAQSQSYAGYAQLDSLD----SGLFAS---GSNATPSYGELYQSLSYG----------STQITS 634
             :.:.:.......||:|.    :.:|.:   ||.|:.::.:...||..|          |..::|
  Rat   492 IEEEEEEGGSVGNLDNLSCFHLADIFGTGDPGSLASWTHSQFGSSLPSGILDENANLDASCFLSS 556

  Fly   635 YTAAYQQ-----HSASPAVAVAPGAPSSCAYSSC----AVPSVPPYGNATTTASSNVPYQTTAVS 690
            .....::     .|.||....|..:....:.|||    .:.|:|.|        |..|:.|
  Rat   557 GLEGLREGSLPSSSGSPEGEAAQSSSLDLSLSSCDSFELLQSLPDY--------SLGPHYT---- 609

  Fly   691 MTAASTSASPSRLVGNPVGS-ATASPATVSSSPATASG-NEFISLSTPI 737
                      ||.|...:.| .|..|:...|.|..||. :..|.||.|:
  Rat   610 ----------SRRVSGSLDSLETFHPSPSFSPPRDASFLDSLIGLSEPV 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axud1	NP_001259928.1	CSRNP_N	301..500	CDD:292638	101/222 (45%)
Axud1	NP_001259928.1	PHA03255	643..>786	CDD:165513	27/101 (27%)
Csrnp1	XP_038937740.1	CSRNP_N	169..392	CDD:406427	102/225 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354293
Domainoid	1	1.000	217	1.000	Domainoid score	I2595
eggNOG	1	0.900	-	-		E1_KOG3813
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001585
OrthoInspector	1	1.000	-	-		otm44756
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13580
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.800