DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axud1 and trim37

DIOPT Version :9

Sequence 1:	NP_001259928.1	Gene:	Axud1 / 33419	FlyBaseID:	FBgn0261647	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_012811670.1	Gene:	trim37 / 100036717	XenbaseID:	XB-GENE-984993	Length:	1030	Species:	Xenopus tropicalis

Alignment Length:	831	Identity:	154/831 - (18%)
Similarity:	270/831 - (32%)	Gaps:	276/831 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DIERQI----KTSIIDAS--------KVHAAKAKALASLPMPLEQLDDELADFAHGPADTELEEQ 133
            ::|.|:    |:.:|..|        :||.....:..:.|:|        .||.        .|.
Frog   270 EVEHQLRSCSKSELISKSPEILMMFQQVHRKPMASFVTTPVP--------PDFT--------RED 318

  Fly   134 F--LELENYPNNEIIVLGDADLNSSIA----------SDAVSEDPLAIDNILDSASVTTNEEVDT 186
            |  ::|:.:.|.|...|..|..:::..          :|.|...||.:..:.....|..:.....
Frog   319 FVGIQLQAFDNIEASELVPAYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVV 383

  Fly   187 SGELL--WLKLN---NETEMATRSAEVVSNNQASLEPAQPAKPKEDELRDGGSDSGLG------- 239
            .|..|  :|:|:   .||.......|:|  :|:|.:||      ::.:|:..||..:|
Frog   384 RGYYLSVFLELSAGLPETSKYEYRVEMV--HQSSNDPA------KNIIREFASDFEVGECWGYNR 440

  Fly   240 ---------------SETSALLKDQAEKEAEPEIQKK-------------VETKPIR--SNLKRR 274
                           :..:.:|:.|..   .|...:|             .:|..|:  :|||.|
Frog   441 FFRLDLLANEGYLNRTNDTVILRFQVR---SPTFFQKCRDQHWYISQLEAAQTSYIQQINNLKER 502

  Fly   275 L-----EDSESDAIDLVPDMSAPP---VAPQKRTKRS-INFDEVKVFYFPRQ------QGFSCVP 324
            |     .:.:|..:. .||....|   .:|:.|:|:: :|.:.:.....||:      :..|.
Frog   503 LTIELSRNQKSRGMS-PPDTHLSPQNDESPEARSKKTDVNLESISSLPAPREAEEDEDKSLSV-- 564

  Fly   325 TAGGCTLGMGARHVGFKTMTLAEHAAELRRAHRSQNQELQPRGSSSDDSEES--EEDYLSEGSGS 387
                           |....|::...::..|...:...|:...||:..:..|  ||:.:.|.:.|
Frog   565 ---------------FNQQDLSDGDLDVDLAGEDEANHLEGSCSSASSTATSITEENDIDEETMS 614

  Fly   388 DAEDGSNGFLQPVTPKQRRALLKAAGVRKIDASEKSECRDIRNSREVCGCSCREFCDPETC-ACS 451
            ...|                 ::.:|...::..|..|                   ||.|. |..
Frog   615 GEND-----------------VEYSGNMDLEEGELME-------------------DPSTAGAAG 643

  Fly   452 QAGIKCQVDRAMFPCGCTREACGNTVGR------VEFNPTRVRTHYIHTVMRLDLEQRQGSVQGV 510
            ..|         :..|......|:.:|.      ::.:|    ..:||.   |||:.| .|::.:
Frog   644 GHG---------YGSGRNSRRTGSNIGSTSSSSLLDLDP----LIFIHL---LDLKDR-NSMENL 691

  Fly   511 QGGHLQP----------------QQQQPSQQTIGYSPVGTAGSTSAYFLQTQSNYSSGYASPAYT 559
            ..  |||                ::.|..|||             ::.:.........|.|....
Frog   692 WS--LQPRPPTSILQASASCSRKERDQRRQQT-------------SWRVSPDLKMLKRYKSQVLE 741

  Fly   560 PESSVSYYQQQVQQPGVPTAGQLIPQQQQAQSQSYAG-YAQLDSLDSGLFASGSNATPSYG-ELY 622
            ..|.:|..:.|:.:         :.....|.::::.| ...||||.|. .|.|.......| ||.
Frog   742 VRSKLSAVKNQLCE---------VRNNNTAVTENHCGSTGDLDSLTSS-SAEGCTKLQELGMELL 796

  Fly   623 QSLSYGSTQITSYTAAYQ---QHSASPAVAVAPGAPSSCAYSSCAVPSVPPYGNATTTASSNVPY 684
            :..|..|..:.|.::...   :||.|...|   ||.|......|.            ..|..|..
Frog   797 RKSSLASCYVRSASSKKSNSPKHSRSGEKA---GALSLRRAMECG------------EGSHRVKA 846

  Fly   685 QTTAVSMTAASTSASPSRLVGNPVGSATASPATVSSSPATASGNEFISLSTPIASSSRLSQINDL 749
            ::.|.|...::.:.:.|| .|:|.....:||...|||......:|.:|           |:|..:
Frog   847 ESQATSEGCSTGTKNVSR-HGSPRSLTNSSPEIPSSSKTDERQSELLS-----------SEIQAM 899

  Fly   750 LQHNRNTTAALVAVSEGLSG---------------GRTSSSASTIDSIDTP 785
            .........:|...|:|.||               |..:|..|.:.|:..|
Frog   900 CMDKGRKVISLGPSSKGWSGKDIVQMGSLDSDHEAGEITSMLSEVASVTYP 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axud1	NP_001259928.1	CSRNP_N	301..500	CDD:292638	32/214 (15%)
Axud1	NP_001259928.1	PHA03255	643..>786	CDD:165513	34/158 (22%)
trim37	XP_012811670.1	RING	61..104	CDD:238093
		zf-B_box	136..178	CDD:279037
		BBC	178..300	CDD:128778	7/29 (24%)
		MATH_TRIM37	336..469	CDD:239742	24/143 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165178117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930