DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and YPT52

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_012939.1	Gene:	YPT52 / 853884	SGDID:	S000001722	Length:	234	Species:	Saccharomyces cerevisiae

Alignment Length:	232	Identity:	119/232 - (51%)
Similarity:	141/232 - (60%)	Gaps:	43/232 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICI--------EDTVVKFEIWDT 85
            ||||||||:|:|||||:|.||||..|.|.:|||||||||:|:|.|        :|.|:|||||||
Yeast     3 QFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAFLSQSITIHPNDGNETKDVVIKFEIWDT 67

  Fly    86 AGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKEL-HKQASPNIVIALAGNKADL--- 146
            ||||||.||||||||.|.||:|||||..:||.|:|:.||.|| :|....::||.|.|||.||
Yeast    68 AGQERYKSLAPMYYRNANAALVVYDITQEDSLQKARNWVDELKNKVGDDDLVIYLLGNKVDLCQE 132

  Fly   147 ---------SN--------IRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKL--PK 192
                     ||        :|.:..:||||||:|.||||.|.|||||..|.:||..|.:||  .|
Yeast   133 TPSTETSPDSNEGGDEEQKVRAISTEEAKQYAQEQGLLFREVSAKTGEGVKEIFQDIGEKLYDLK 197

  Fly   193 ND-----------GANNQGTSIRPTGTETNRPTNNCC 218
            .|           |.||....|......||.|| :||
Yeast   198 KDEILSKQNRQIGGGNNGQVDINLQRPSTNDPT-SCC 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	107/192 (56%)
YPT52	NP_012939.1	Rab5_related	3..194	CDD:206653	106/190 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2000
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840