DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and RAB5C

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001238968.1	Gene:	RAB5C / 5878	HGNCID:	9785	Length:	249	Species:	Homo sapiens

Alignment Length:	221	Identity:	161/221 - (72%)
Similarity:	178/221 - (80%)	Gaps:	5/221 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TTPRSGGASGTGTAQRPNG-TSQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAF 66
            ||......:|.|.|.|||| .:.||.|||||||||||||||||||||||||||||||||||||||
Human    27 TTTAGRAMAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAF 91

  Fly    67 LTQTICIEDTVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQA 131
            ||||:|::||.||||||||||||||||||||||||||||||||||.|.|:|.|||.|||||.:||
Human    92 LTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQA 156

  Fly   132 SPNIVIALAGNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKNDGA 196
            |||||||||||||||::.|.|||.||:.||::|.||||||||||.||||:||:|||||||||:..
Human   157 SPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQ 221

  Fly   197 NNQGTSIRPTGT--ETNRPT--NNCC 218
            |..|...|..|.  :.|.|.  :.||
Human   222 NATGAPGRNRGVDLQENNPASRSQCC 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	137/161 (85%)
RAB5C	NP_001238968.1	Rab5_related	54..216	CDD:206653	137/161 (85%)
RAB5C	NP_001238968.1	Ras	56..217	CDD:278499	136/160 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159252
Domainoid	1	1.000	277	1.000	Domainoid score	I1733
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55533
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2594
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	1	1.000	-	-		FOG0000845
OrthoInspector	1	1.000	-	-		otm41694
orthoMCL	1	0.900	-	-		OOG6_100743
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2000
SonicParanoid	1	1.000	-	-		X457
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.690