Protein Alignment Rab5 and RAB5A

DIOPT Version :9

• Sequence 1: NP_001259925.1
• Gene: Rab5 / 33418
• FlyBaseID: FBgn0014010
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 208
• Identity: 156/208 - (75%)
• Similarity: 174/208 - (83%)
• Gaps: 5/208 - (2%)

  Fly    16 AQRPNG-TSQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVK 79
            |.|||| .:.||.|||||||||||||||||||||||||||||:|||||||||||||:|::||.||
Human     6 ATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVK 70

  Fly    80 FEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGNKA 144
            ||||||||||||||||||||||||||||||||.|::||.|||.|||||.:||||||||||:||||
Human    71 FEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKA 135

  Fly   145 DLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKNDGANNQGTSIRPTGTE 209
            ||:|.|.|:|.||:.||::|.||||||||||.||||:||:|||||||||:..|....|.|..|.:
Human   136 DLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVD 200

  Fly   210 TNRPT----NNCC 218
            ...||    |.||
Human   201 LTEPTQPTRNQCC 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	135/161 (84%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	135/161 (84%)
		Effector region. /evidence=ECO:0000255	49..57		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		13/33 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I1733
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2594
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	1	1.000	-	-		FOG0000845
OrthoInspector	1	1.000	-	-		otm41694
orthoMCL	1	0.900	-	-		OOG6_100743
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2000
SonicParanoid	1	1.000	-	-		X457
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760