Protein Alignment Rab5 and RAB20

DIOPT Version :9

• Sequence 1: NP_001259925.1
• Gene: Rab5 / 33418
• FlyBaseID: FBgn0014010
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_060287.1
• Gene: RAB20 / 55647
• HGNCID: 18260
• Length: 234
• Species: Homo sapiens
• Alignment Length: 242
• Identity: 68/242 - (28%)
• Similarity: 101/242 - (41%)
• Gaps: 69/242 - (28%)

  Fly    31 KLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQERYHSLA 95
            |:||||:..|||:||:.|:::.:|.: ..||:|.||..:    :.......||||||:|::|.|.
Human     7 KIVLLGDMNVGKTSLLQRYMERRFPD-TVSTVGGAFYLK----QWRSYNISIWDTAGREQFHGLG 66

  Fly    96 PMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGNKADLSN------------ 148
            .||.|||.|.|:.||:.::.|....:.....|...||.:.:.|:.|||.||:.
Human    67 SMYCRGAAAIILTYDVNHRQSLVELEDRFLGLTDTASKDCLFAIVGNKVDLTEEGALAGQEKEEC 131

  Fly   149 ------------------------------IRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIF 183
                                          ::....||....|.|.  :..|||||||.||:.:|
Human   132 SPNMDAGDRVSPRAPKQVQLEDAVALYKKILKYKMLDEQDVPAAEQ--MCFETSAKTGYNVDLLF 194

  Fly   184 -----LAIAKKLPKNDGANNQGTSIRPTGT-------ETNRPTNNCC 218
                 |.:...|        |..:.||:.|       ...|..:.||
Human   195 ETLFDLVVPMIL--------QQRAERPSHTVDISSHKPPKRTRSGCC 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	60/206 (29%)
RAB20	NP_060287.1	Rab20	6..233	CDD:133326	66/240 (28%)
		Effector region. /evidence=ECO:0000250	33..41		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	125..144		0/18 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..234		6/22 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820