Protein Alignment Rab5 and RAB14

DIOPT Version :10

• Sequence 1: NP_523457.1
• Gene: Rab5 / 33418
• FlyBaseID: FBgn0014010
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_057406.2
• Gene: RAB14 / 51552
• HGNCID: 16524
• Length: 215
• Species: Homo sapiens
• Alignment Length: 222
• Identity: 90/222 - (40%)
• Similarity: 124/222 - (55%)
• Gaps: 25/222 - (11%)

  Fly     1 MATTPRSGGASGTGTAQRPNGTSQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAA 65
            |||.|                  .|.|..||.:::|:..||||.|:.:|.:.:|......|||..
Human     1 MATAP------------------YNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVE 47

  Fly    66 FLTQTICIEDTVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQ 130
            |.|:.|.:....:|.:|||||||||:.::...|||||..|::||||..:.::....:|:.:....
Human    48 FGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNL 112

  Fly   131 ASPNIVIALAGNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKN-- 193
            .:||.||.|.||||||...|.|.::||||:||||||||:|.|||||.||.|.||..|||:.:|
Human   113 TNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQ 177

  Fly   194 DG-----ANNQGTSIRPTGTETNRPTN 215
            ||     |...|...:|:..:..|.|:
Human   178 DGSLDLNAAESGVQHKPSAPQGGRLTS 204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_523457.1	Rab5_related	29..191	CDD:206653	76/161 (47%)
RAB14	NP_057406.2	Rab14	10..175	CDD:133322	76/164 (46%)
		Switch 1. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	42..47		3/4 (75%)
		Switch 2. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	68..77		5/8 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..215		4/17 (24%)