DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and ran

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001004829.1	Gene:	ran / 448091	XenbaseID:	XB-GENE-489468	Length:	216	Species:	Xenopus tropicalis

Alignment Length:	164	Identity:	55/164 - (33%)
Similarity:	91/164 - (55%)	Gaps:	7/164 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQERYHS 93
            ||||||:|:...||::.|.|.:.|:|.:...:|:|..............:||.:|||||||::..
Frog    10 QFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGG 74

  Fly    94 LAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGNKADLSNIRVVEFDEAK 158
            |...||..||.||:::|:.::.:::....|.::| .:...||.|.|.|||.|:.:.:|    :||
Frog    75 LRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDL-VRVCENIPIVLCGNKVDIKDRKV----KAK 134

  Fly   159 Q--YAEENGLLFMETSAKTGMNVNDIFLAIAKKL 190
            .  :..:..|.:.:.|||:..|....||.:|:||
Frog   135 SIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKL 168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	55/164 (34%)
ran	NP_001004829.1	PTZ00132	1..216	CDD:240284	55/164 (34%)
ran	NP_001004829.1	Interaction with RANBP1. /evidence=ECO:0000250\|UniProtKB:P62826	211..216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910