DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and rab5b

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_998050.1	Gene:	rab5b / 405821	ZFINID:	ZDB-GENE-040426-2593	Length:	214	Species:	Danio rerio

Alignment Length:	214	Identity:	144/214 - (67%)
Similarity:	174/214 - (81%)	Gaps:	13/214 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GTGTAQRPNGT-SQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIED 75
            |||   |.||. .|.|.|||||||||:.||||||||||||||||.|:||:|||||||.|::|::|
Zfish     5 GTG---RANGNLPQTKICQFKLVLLGDMAVGKSSLVLRFVKGQFDEFQETTIGAAFLAQSVCLDD 66

  Fly    76 TVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALA 140
            |.|||||||||||||||||||||||||||||||:||...::|:|||.|||||.:|||||||||||
Zfish    67 TTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVFDITKPETFERAKAWVKELQRQASPNIVIALA 131

  Fly   141 GNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKND------GANNQ 199
            ||||||::.|:||::||:.|||:.|||||||||||.||||::|||||||:||.|      .|.::
Zfish   132 GNKADLADKRLVEYEEAQTYAEDTGLLFMETSAKTAMNVNELFLAIAKKMPKTDTQNPTHAARHR 196

  Fly   200 GTSIRPTGTETNRPTNNCC 218
            |.:::....::   |.:||
Zfish   197 GVNLQDPDAQS---TRSCC 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	127/161 (79%)
rab5b	NP_998050.1	Rab5_related	20..182	CDD:206653	127/161 (79%)
rab5b	NP_998050.1	Ras	22..183	CDD:278499	125/160 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	1	1.000	-	-		FOG0000845
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2000
SonicParanoid	1	1.000	-	-		X457
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.910