DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and KRAS

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001356715.1	Gene:	KRAS / 3845	HGNCID:	6407	Length:	189	Species:	Homo sapiens

Alignment Length:	163	Identity:	51/163 - (31%)
Similarity:	92/163 - (56%)	Gaps:	3/163 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQERYHS 93
            ::|||::|...||||:|.::.::..|.:..:.||..::..|.: |:......:|.||||||.|.:
Human     3 EYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVV-IDGETCLLDILDTAGQEEYSA 66

  Fly    94 LAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHK-QASPNIVIALAGNKADLSNIRVVEFDEA 157
            :...|.|..:..:.|:.|.|..||:....:.:::.: :.|.::.:.|.|||.||.: |.|:..:|
Human    67 MRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPS-RTVDTKQA 130

  Fly   158 KQYAEENGLLFMETSAKTGMNVNDIFLAIAKKL 190
            :..|...|:.|:||||||...|.|.|..:.:::
Human   131 QDLARSYGIPFIETSAKTRQRVEDAFYTLVREI 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	51/163 (31%)
KRAS	NP_001356715.1	H_N_K_Ras_like	3..164	CDD:133338	51/163 (31%)
		Effector region	32..40		2/7 (29%)
		Hypervariable region	166..185
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910