DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and rab5aa

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_958893.1	Gene:	rab5aa / 337737	ZFINID:	ZDB-GENE-030131-139	Length:	216	Species:	Danio rerio

Alignment Length:	211	Identity:	158/211 - (74%)
Similarity:	180/211 - (85%)	Gaps:	7/211 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GTAQRPNGTSQ-NKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTV 77
            |.|.||||::. ||.|||||||||||||||||||||||||||||:|||||||||||||:|::||.
Zfish     5 GGATRPNGSNAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTLCLDDTT 69

  Fly    78 VKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGN 142
            ||||||||||||||||||||||||||||||||||.|::||.|||.|||||.:||||||||||:||
Zfish    70 VKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGN 134

  Fly   143 KADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKND----GANNQGTSI 203
            ||||:|.|.|:|.:|:.||::|.||||||||||.||||:||:||||||||::    |||: |.|.
Zfish   135 KADLANKRAVDFQDAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKSEPQAAGANS-GRSR 198

  Fly   204 RPTGTETNRPTN-NCC 218
            ....|||.:||. .||
Zfish   199 GVDLTETAQPTKAPCC 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	134/161 (83%)
rab5aa	NP_958893.1	Rab5_related	21..183	CDD:206653	134/161 (83%)
rab5aa	NP_958893.1	Ras	23..184	CDD:278499	133/160 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1717
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2632
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	1	1.000	-	-		FOG0000845
OrthoInspector	1	1.000	-	-		otm25041
orthoMCL	1	0.900	-	-		OOG6_100743
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2000
SonicParanoid	1	1.000	-	-		X457
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760