DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and Rab27

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_726743.1	Gene:	Rab27 / 31103	FlyBaseID:	FBgn0025382	Length:	236	Species:	Drosophila melanogaster

Alignment Length:	174	Identity:	57/174 - (32%)
Similarity:	95/174 - (54%)	Gaps:	10/174 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDT----VVKFEIWDTAGQERY 91
            :.::||:|.|||:.|:.::..|:||....||:|..|..:.:.....    .:..:|||||||||:
  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERF 83

  Fly    92 HSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQA---SPNIVIALAGNKADLSNIRVVE 153
            .||...:||.|...::::|:.::.||.....|:.:|...|   .|::|  |.|||.||..:|||.
  Fly    84 RSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVV--LCGNKCDLLQLRVVS 146

  Fly   154 FDEAKQYAEENGLLFMETSAKTGMNVND-IFLAIAKKLPKNDGA 196
            .|:.........|.::||||.||.||.: :.|.:.:.:.:.:.|
  Fly   147 RDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENA 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	56/167 (34%)
Rab27	NP_726743.1	P-loop_NTPase	19..187	CDD:304359	56/169 (33%)
Rab27	NP_726743.1	RAB	20..186	CDD:197555	56/167 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840