Protein Alignment Rab5 and Rab21

DIOPT Version :10

• Sequence 1: NP_523457.1
• Gene: Rab5 / 33418
• FlyBaseID: FBgn0014010
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_077774.1
• Gene: Rab21 / 216344
• MGIID: 894308
• Length: 222
• Species: Mus musculus
• Alignment Length: 222
• Identity: 86/222 - (38%)
• Similarity: 126/222 - (56%)
• Gaps: 18/222 - (8%)

  Fly    10 ASGTGTAQRPNGTSQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIE 74
            |:|.|.|     .:..::..||:|||||..|||:|||||:.:.:|::...:|:.|:|||:.:.|.
Mouse     3 AAGGGAA-----AAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIG 62

  Fly    75 DTVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIAL 139
            ...|...|||||||||:|:|.|:|||.:..||:|||:.::||||:.|.|||||.|.....|.:.:
Mouse    63 GKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDVTDEDSFQKVKNWVKELRKMLGNEICLCI 127

  Fly   140 AGNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKL---------PKNDG 195
            .|||.||...|.|...||:.|||..|.....||||....:.::||.:.|::         .|.:|
Mouse   128 VGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNG 192

  Fly   196 ANNQGTSIRPTGTETNRP----TNNCC 218
            ::..|.:.|......:.|    :..||
Mouse   193 SSQAGAARRGVQIIDDEPQAQSSGGCC 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_523457.1	Rab5_related	29..191	CDD:206653	75/170 (44%)
Rab21	NP_077774.1	Rab21	18..179	CDD:133323	75/160 (47%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:Q9UL25	41..54		3/12 (25%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:Q9UL25	74..92		11/17 (65%)