DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and Rab22a

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_077756.2	Gene:	Rab22a / 19334	MGIID:	105072	Length:	194	Species:	Mus musculus

Alignment Length:	193	Identity:	86/193 - (44%)
Similarity:	133/193 - (68%)	Gaps:	6/193 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQERYHS 93
            :.|:.|||::.|||||:|.|||:..|......||||:|:|:|:..::.:.||.|||||||||:.:
Mouse     5 ELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRA 69

  Fly    94 LAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGNKADLSNIRVVEFDEAK 158
            ||||||||:.|||:||||..:::|...|.||:||.:...|:||:|:||||.||:::|.|...:||
Mouse    70 LAPMYYRGSAAAIIVYDITKEETFSTLKNWVRELRQHGPPSIVVAIAGNKCDLTDVREVMERDAK 134

  Fly   159 QYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKND---GANNQGTSIRPTGTETNRPTNNCC 218
            .||:....:|:|||||..:|:|::|:.|::::|..|   .:..:|..:|   .:.:.|..:||
Mouse   135 DYADSIHAIFVETSAKNAININELFIEISRRIPSTDANPASGGKGFKLR---RQPSEPKRSCC 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	79/161 (49%)
Rab22a	NP_077756.2	Rab5_related	5..167	CDD:206653	79/161 (49%)
		Effector region. /evidence=ECO:0000250	34..42		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..194		4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820