DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and rab-21

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_495854.1	Gene:	rab-21 / 187932	WormBaseID:	WBGene00004279	Length:	207	Species:	Caenorhabditis elegans

Alignment Length:	199	Identity:	81/199 - (40%)
Similarity:	118/199 - (59%)	Gaps:	5/199 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQER 90
            ||.:||:|||||..|||||||||||:.:|.....|||.|:|..:|:.:||......||||||||:
Worm     9 KSFKFKIVLLGEGCVGKSSLVLRFVENKFSCKHLSTIQASFQNKTVNVEDCQADLHIWDTAGQEK 73

  Fly    91 YHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIALAGNKADLSNIRVVEFD 155
            ||:|.|:||||:...::|:||.::.||::.|.||.|:.........|.:.|||.||...|.|...
Worm    74 YHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNTAEILIVGNKIDLEEERQVTRQ 138

  Fly   156 EAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKNDGAN-----NQGTSIRPTGTETNRPTN 215
            :|:.|||..|.|:|||||:..:.::|.|.::..|:.::....     :...|||....:....:.
Worm   139 DAEAYAESEGALYMETSAQDNVGISDAFESLTAKMIEHSRTRSTEPPSTNRSIRLIDNDEAERSK 203

  Fly   216 NCCK 219
            .||:
Worm   204 KCCR 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	74/161 (46%)
rab-21	NP_495854.1	Rab21	13..174	CDD:133323	74/160 (46%)
rab-21	NP_495854.1	Ras	14..175	CDD:278499	73/160 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910