DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and C52B11.5

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_508236.1	Gene:	C52B11.5 / 183717	WormBaseID:	WBGene00016874	Length:	238	Species:	Caenorhabditis elegans

Alignment Length:	213	Identity:	52/213 - (24%)
Similarity:	98/213 - (46%)	Gaps:	32/213 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SQNKSCQF----------------KLVLLGESAVGKSSLVLRFVKGQFHEYQES-----TIGAAF 66
            |||...|.                |::::|....|||:.:.|...|:|||.:::     .|....
Worm     2 SQNTESQMLVALPADYIPEASRRCKIIVVGAKNAGKSTFIERVEFGKFHEEKQTEKLYRVIAKKV 66

  Fly    67 LTQTICIEDTVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQA 131
            ..||:.:|  :::.::.....::.......|  |...|.::.|...:.:||::.|..:..:.::.
Worm    67 FEQTLTVE--LIEKDLGGLTNEDNGFKKTEM--RDVDAVLLFYAADDLESFKQLKENLVHVQRKI 127

  Fly   132 SPNIVIALAGNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNV----NDIFLAIAKKLPK 192
            .||..|.:.|.|||:..:: |::.|...:||..|....|||:|||:||    :||...|.::...
Worm   128 PPNANITVVGTKADVKEMQ-VQWQEVDSFAENQGFSCFETSSKTGVNVEIILHDILETIFERRFA 191

  Fly   193 NDGANNQGTSIRPTGTET 210
            :|  :::..|.:|....|
Worm   192 SD--DDEVLSNQPVYAST 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	45/186 (24%)
C52B11.5	NP_508236.1	P-loop_NTPase	25..183	CDD:304359	43/162 (27%)
C52B11.5	NP_508236.1	Ras	26..187	CDD:278499	44/165 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810