DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and rab-33

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_499314.1	Gene:	rab-33 / 176470	WormBaseID:	WBGene00004283	Length:	307	Species:	Caenorhabditis elegans

Alignment Length:	236	Identity:	78/236 - (33%)
Similarity:	117/236 - (49%)	Gaps:	25/236 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PRSGGASGTGTAQRPNGTSQNKSCQ-FKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLT 68
            |.:..|.....|..|:.|...|..: ||::::|.:||||:.|..||..|:|.|:.|:|||..|..
Worm    75 PEAVTAGPKKMALAPSSTKTYKQKRTFKVIIVGNAAVGKTCLSFRFCCGRFPEHTEATIGVDFRE 139

  Fly    69 QTICIEDTVVKFEIWDTAGQERY-HSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQA- 131
            ::..||:.:::.::||||||||| .|:...|||...|.:.|||:..::||.....|:||..|..
Worm   140 RSCVIENELLRVQLWDTAGQERYRQSIVAHYYRNVNAVVFVYDVTCRESFNDLALWIKECEKHGL 204

  Fly   132 -----SPNIVIALAGNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGM---NVNDIFLAIAK 188
                 .|.|:|   |||.|:.....|..|||:.:|:.|.:...|||||...   :|..|||.:..
Worm   205 VGDSEVPRILI---GNKCDVECTNRVSTDEAQMFADRNNMALFETSAKLASEADHVESIFLTLLH 266

  Fly   189 KLPKNDGANNQGTS-----------IRPTGTETNRPTNNCC 218
            ||.::...:.|...           ::...||.......||
Worm   267 KLQQSKPMHVQSQDERHQKEQERLILKANETENVEEEGFCC 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	66/172 (38%)
rab-33	NP_499314.1	Rab33B_Rab33A	99..270	CDD:133315	67/173 (39%)
rab-33	NP_499314.1	RAB	101..270	CDD:197555	67/171 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010