DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab5 and rab-5

DIOPT Version :9

Sequence 1:	NP_001259925.1	Gene:	Rab5 / 33418	FlyBaseID:	FBgn0014010	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_492481.1	Gene:	rab-5 / 172755	WormBaseID:	WBGene00004268	Length:	208	Species:	Caenorhabditis elegans

Alignment Length:	215	Identity:	158/215 - (73%)
Similarity:	177/215 - (82%)	Gaps:	14/215 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ASGTGTAQRPNGTSQNKSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIE 74
            |...||| ||.|  .|::|||||||||||||||||||||||||||||||||||||||||||:|::
Worm     3 ARNAGTA-RPGG--PNRTCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLD 64

  Fly    75 DTVVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKELHKQASPNIVIAL 139
            |..:|||||||||||||||||||||||||||||||||.||:|||:||.|||||.:|||||||:||
Worm    65 DATIKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQESFQKAKNWVKELQRQASPNIVMAL 129

  Fly   140 AGNKADLSNIRVVEFDEAKQYAEENGLLFMETSAKTGMNVNDIFLAIAKKLPKNDGANNQGTSIR 204
            ||||||::|.|.||::||..|||:|.||||||||||.|||||||:|||||||....   ||   .
Worm   130 AGNKADVANKRTVEYEEANAYAEDNALLFMETSAKTSMNVNDIFMAIAKKLPIGPA---QG---E 188

  Fly   205 PTGT-ETNRP----TNNCCK 219
            |||| :.|:|    ..:|||
Worm   189 PTGTVDMNQPQQQQKGSCCK 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab5	NP_001259925.1	Rab5_related	29..191	CDD:206653	136/161 (84%)
rab-5	NP_492481.1	Rab5_related	19..181	CDD:206653	136/161 (84%)
rab-5	NP_492481.1	Ras	21..181	CDD:278499	134/159 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166832
Domainoid	1	1.000	277	1.000	Domainoid score	I913
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	300	1.000	Inparanoid score	I1633
Isobase	1	0.950	-	0	Normalized mean entropy	S266
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	1	1.000	-	-		FOG0000845
OrthoInspector	1	1.000	-	-		oto20248
orthoMCL	1	0.900	-	-		OOG6_100743
Panther	1	1.100	-	-	LDO	PTHR24073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2000
SonicParanoid	1	1.000	-	-		X457
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.780