DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17237 and MYL1

DIOPT Version :9

Sequence 1:	NP_608666.1	Gene:	CG17237 / 33411	FlyBaseID:	FBgn0031410	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_524144.1	Gene:	MYL1 / 4632	HGNCID:	7582	Length:	194	Species:	Homo sapiens

Alignment Length:	175	Identity:	52/175 - (29%)
Similarity:	84/175 - (48%)	Gaps:	24/175 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 APPPNPKPEKSRIMEMHAI---------------FLGHDTRGDNKISIRHLGHCLRAMGATPTEA 82
            ||.|.|...|...:::.||               ||..|..||:||::..:|..|||:|..||.|
Human    25 APAPAPAKPKEEKIDLSAIKIEFSKEQQDEFKEAFLLFDRTGDSKITLSQVGDVLRALGTNPTNA 89

  Fly    83 MVSKHV--RQYEASTMQRICFDEVMGIYSSLGKHGGMLSPKKKQIEADQFVSSLRVFDTDKSGWI 145
            .|.|.:  ...|....::|.|::.:.:..:       :|..|.|...:.||..|||||.:.:|.:
Human    90 EVRKVLGNPSNEELNAKKIEFEQFLPMMQA-------ISNNKDQATYEDFVEGLRVFDKEGNGTV 147

  Fly   146 PAIRLRRILTKTGECMGSMEVDELLQGRINKDGLVDYKKLVQDII 190
            ....||.:|...||.|...||:.|:.|:.:.:|.::|:..|:.|:
Human   148 MGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCINYEAFVKHIM 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17237	NP_608666.1	PTZ00184	45..187	CDD:185504	45/158 (28%)
CG17237	NP_608666.1	EFh	129..187	CDD:298682	20/57 (35%)
MYL1	NP_524144.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		4/9 (44%)
		PTZ00184	45..193	CDD:185504	45/155 (29%)
		EFh	54..118	CDD:298682	20/63 (32%)
		EF-hand_6	54..83	CDD:290141	11/28 (39%)
		EFh	131..192	CDD:238008	21/60 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0030
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S901
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860