DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sec24CD and SEC24D

DIOPT Version :9

Sequence 1:NP_001259918.1 Gene:Sec24CD / 33409 FlyBaseID:FBgn0262126 Length:1231 Species:Drosophila melanogaster
Sequence 2:NP_001304995.1 Gene:SEC24D / 9871 HGNCID:10706 Length:1033 Species:Homo sapiens


Alignment Length:1212 Identity:490/1212 - (40%)
Similarity:690/1212 - (56%) Gaps:198/1212 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNPNMYGPPPTQFQQQPQFGAPPPNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSA 65
            |:...|...|...|.||..|..||:.|                            .||.|..|::
Human     1 MSQQGYVATPPYSQPQPGIGLSPPHYG----------------------------HYGDPSHTAS 37

  Fly    66 ASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAA----- 125
            .:                 |:....|..||...:..||.|      |||.|.:||..|.|     
Human    38 PT-----------------GMMKPAGPLGATATRGMLPPG------PPPPGPHQFGQNGAHATGH 79

  Fly   126 -------PPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPP 183
                   |||.||..::.....|:...|| .|.:..||..| :.|.::.|.:||....    |.|
Human    80 PPQRFPGPPPVNNVASSHAPYQPSAQSSY-PGPISTSSVTQ-LGSQLSAMQINSYGSG----MAP 138

  Fly   184 PKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLP 248
            |....||      |: :|.|...||.|.||.:                        .:||...||
Human   139 PSQGPPG------PL-SATSLQTPPRPPQPSI------------------------LQPGSQVLP 172

  Fly   249 PGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGL--PPQPGAPYGAPQ 311
            |  .|.|...||..|     :|      :|..:|              .||  ||.|.|.|    
Human   173 P--PPTTLNGPGASP-----LP------LPMYRP--------------DGLSGPPPPNAQY---- 206

  Fly   312 QGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQQPMPGYPPQPG 376
                              .|||||||...|                ||||   ||.....|...|
Human   207 ------------------QPPPLPGQTLGA----------------GYPP---QQAANSGPQMAG 234

  Fly   377 QQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQVMIENQRLS 441
            .||..||       ||||.|.:  ...||.|           .::||||.:|:|||| |||.|.|
Human   235 AQLSYPG-------GFPGGPAQ--MAGPPQP-----------QKKLDPDSIPSPIQV-IENDRAS 278

  Fly   442 --GGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAK 504
              |..:.||..|.:||||||..::.||||:||||:|.:.||.|.|.|:.|...:||...|.|.|.
Human   279 RGGQVYATNTRGQIPPLVTTDCMIQDQGNASPRFIRCTTYCFPCTSDMAKQAQIPLAAVIKPFAT 343

  Fly   505 VGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQ 569
            :...|....:||.||.||:|||||||||.|.|||::.|||:||..|...::|...|:|||||.|:
Human   344 IPSNESPLYLVNHGESGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCNCVNDVPPFYFQHLDHIGR 408

  Fly   570 RVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHL 634
            |:|.:|:|||.||:||::||.||||.:.||..|||||:|||||:.:|:|||.|:|.::|.:|:.:
Human   409 RLDHYEKPELSLGSYEYVATLDYCRKSKPPNPPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKI 473

  Fly   635 PVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVID 699
            |.::.::.|.:||||||||..:||:|:||:|||||||||.||.|:|:|||||||.:.:||.:||.
Human   474 PKEEQEETSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGEVFVPLLDGFLVNYQESQSVIH 538

  Fly   700 ALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLL 764
            .|:::||.||||:.|.||:..|.||||:|||||::..|||.:|:|:||.||||||||||||:||:
Human   539 NLLDQIPDMFADSNENETVFAPVIQAGMEALKAADCPGKLFIFHSSLPTAEAPGKLKNRDDKKLV 603

  Fly   765 GTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQAD 829
            .|||||.:..|||..|::|.::||..||||.||:|.:.|:|:|::|.|.:||||.::||..||..
Human   604 NTDKEKILFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYNNFQMH 668

  Fly   830 VDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIK 894
            :|.::.:.|:..::.:.|.|||:||||||.|.|.|:|:|...|:||||||:|:||..|::::|.|
Human   669 LDRQQFLNDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGILMNNTTDVEMAAIDCDKAVTVEFK 733

  Fly   895 HDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKL 959
            |||||:.:....:|.|:|||:.||||||||.||.|..::.:||::|.|:.||::.||||.| ||.
Human   734 HDDKLSEDSGALIQCAVLYTTISGQRRLRIHNLGLNCSSQLADLYKSCETDALINFFAKSA-FKA 797

  Fly   960 MEHSP-KQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDM 1023
            :.|.| |.:::.|::::|.:||||||:|.||::|.|||||:.:|:||:|.:|||||..:....::
Human   798 VLHQPLKVIREILVNQTAHMLACYRKNCASPSAASQLILPDSMKVLPVYMNCLLKNCVLLSRPEI 862

  Fly  1024 TLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILENGVH 1088
            :.|:|:|..|.:::|.:..|..:.||:.:|||.:..:.|.||..|||:..:..|:|.::|.||:|
Human   863 STDERAYQRQLVMTMGVADSQLFFYPQLLPIHTLDVKSTMLPAAVRCSESRLSEEGIFLLANGLH 927

  Fly  1089 LFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPE--TPLAKRIHGILEQIMKERSRYMRITWL 1151
            :|:|||.:..|:.:|.:|.|.....|..: ..::||  .|.::::..|:..|.::|...|::|.:
Human   928 MFLWLGVSSPPELIQGIFNVPSFAHINTD-MTLLPEVGNPYSQQLRMIMGIIQQKRPYSMKLTIV 991

  Fly  1152 RQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            :|.::.|.|||.|||||:|..|.:|||||||.:||||..||:
Human   992 KQREQPEMVFRQFLVEDKGLYGGSSYVDFLCCVHKEICQLLN 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec24CDNP_001259918.1 COG5028 395..1190 CDD:227361 386/799 (48%)
zf-Sec23_Sec24 522..559 CDD:282641 21/36 (58%)
Sec24-like 599..847 CDD:238756 133/247 (54%)
Sec23_BS 848..932 CDD:285301 48/83 (58%)
Sec23_helical 950..1043 CDD:282646 41/93 (44%)
Gelsolin 1061..1135 CDD:279020 24/75 (32%)
SEC24DNP_001304995.1 Atrophin-1 <8..294 CDD:331285 122/462 (26%)
zf-Sec23_Sec24 182..1028 CDD:331931 420/934 (45%)
Zinc finger-like 364..389 17/24 (71%)
Gelsolin-like. /evidence=ECO:0000255 902..975 23/73 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147917
Domainoid 1 1.000 322 1.000 Domainoid score I1221
eggNOG 1 0.900 - - E1_COG5028
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 960 1.000 Inparanoid score I331
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53542
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001889
OrthoInspector 1 1.000 - - otm40824
orthoMCL 1 0.900 - - OOG6_101536
Panther 1 1.100 - - O PTHR13803
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1962
SonicParanoid 1 1.000 - - X1423
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.790

Return to query results.
Submit another query.