Protein Alignment Sec24CD and SEC24D

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: NP_001304995.1
• Gene: SEC24D / 9871
• HGNCID: 10706
• Length: 1033
• Species: Homo sapiens
• Alignment Length: 1212
• Identity: 490/1212 - (40%)
• Similarity: 690/1212 - (56%)
• Gaps: 198/1212 - (16%)

  Fly     1 MNPNMYGPPPTQFQQQPQFGAPPPNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSA 65
            |:...|...|...|.||..|..||:.|                            .||.|..|::
Human     1 MSQQGYVATPPYSQPQPGIGLSPPHYG----------------------------HYGDPSHTAS 37

  Fly    66 ASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAA----- 125
            .:                 |:....|..||...:..||.|      |||.|.:||..|.|
Human    38 PT-----------------GMMKPAGPLGATATRGMLPPG------PPPPGPHQFGQNGAHATGH 79

  Fly   126 -------PPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPP 183
                   |||.||..::.....|:...|| .|.:..||..| :.|.::.|.:||....    |.|
Human    80 PPQRFPGPPPVNNVASSHAPYQPSAQSSY-PGPISTSSVTQ-LGSQLSAMQINSYGSG----MAP 138

  Fly   184 PKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLP 248
            |....||      |: :|.|...||.|.||.:                        .:||...||
Human   139 PSQGPPG------PL-SATSLQTPPRPPQPSI------------------------LQPGSQVLP 172

  Fly   249 PGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGL--PPQPGAPYGAPQ 311
            |  .|.|...||..|     :|      :|..:|              .||  ||.|.|.|
Human   173 P--PPTTLNGPGASP-----LP------LPMYRP--------------DGLSGPPPPNAQY---- 206

  Fly   312 QGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQQPMPGYPPQPG 376
                              .|||||||...|                ||||   ||.....|...|
Human   207 ------------------QPPPLPGQTLGA----------------GYPP---QQAANSGPQMAG 234

  Fly   377 QQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQVMIENQRLS 441
            .||..||       ||||.|.:  ...||.|           .::||||.:|:|||| |||.|.|
Human   235 AQLSYPG-------GFPGGPAQ--MAGPPQP-----------QKKLDPDSIPSPIQV-IENDRAS 278

  Fly   442 --GGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAK 504
              |..:.||..|.:||||||..::.||||:||||:|.:.||.|.|.|:.|...:||...|.|.|.
Human   279 RGGQVYATNTRGQIPPLVTTDCMIQDQGNASPRFIRCTTYCFPCTSDMAKQAQIPLAAVIKPFAT 343

  Fly   505 VGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQ 569
            :...|....:||.||.||:|||||||||.|.|||::.|||:||..|...::|...|:|||||.|:
Human   344 IPSNESPLYLVNHGESGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCNCVNDVPPFYFQHLDHIGR 408

  Fly   570 RVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHL 634
            |:|.:|:|||.||:||::||.||||.:.||..|||||:|||||:.:|:|||.|:|.::|.:|:.:
Human   409 RLDHYEKPELSLGSYEYVATLDYCRKSKPPNPPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKI 473

  Fly   635 PVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVID 699
            |.::.::.|.:||||||||..:||:|:||:|||||||||.||.|:|:|||||||.:.:||.:||.
Human   474 PKEEQEETSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGEVFVPLLDGFLVNYQESQSVIH 538

  Fly   700 ALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLL 764
            .|:::||.||||:.|.||:..|.||||:|||||::..|||.:|:|:||.||||||||||||:||:
Human   539 NLLDQIPDMFADSNENETVFAPVIQAGMEALKAADCPGKLFIFHSSLPTAEAPGKLKNRDDKKLV 603

  Fly   765 GTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQAD 829
            .|||||.:..|||..|::|.::||..||||.||:|.:.|:|:|::|.|.:||||.::||..||..
Human   604 NTDKEKILFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYNNFQMH 668

  Fly   830 VDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIK 894
            :|.::.:.|:..::.:.|.|||:||||||.|.|.|:|:|...|:||||||:|:||..|::::|.|
Human   669 LDRQQFLNDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGILMNNTTDVEMAAIDCDKAVTVEFK 733

  Fly   895 HDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKL 959
            |||||:.:....:|.|:|||:.||||||||.||.|..::.:||::|.|:.||::.||||.| ||.
Human   734 HDDKLSEDSGALIQCAVLYTTISGQRRLRIHNLGLNCSSQLADLYKSCETDALINFFAKSA-FKA 797

  Fly   960 MEHSP-KQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDM 1023
            :.|.| |.:::.|::::|.:||||||:|.||::|.|||||:.:|:||:|.:|||||..:....::
Human   798 VLHQPLKVIREILVNQTAHMLACYRKNCASPSAASQLILPDSMKVLPVYMNCLLKNCVLLSRPEI 862

  Fly  1024 TLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILENGVH 1088
            :.|:|:|..|.:::|.:..|..:.||:.:|||.:..:.|.||..|||:..:..|:|.::|.||:|
Human   863 STDERAYQRQLVMTMGVADSQLFFYPQLLPIHTLDVKSTMLPAAVRCSESRLSEEGIFLLANGLH 927

  Fly  1089 LFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPE--TPLAKRIHGILEQIMKERSRYMRITWL 1151
            :|:|||.:..|:.:|.:|.|.....|..: ..::||  .|.::::..|:..|.::|...|::|.:
Human   928 MFLWLGVSSPPELIQGIFNVPSFAHINTD-MTLLPEVGNPYSQQLRMIMGIIQQKRPYSMKLTIV 991

  Fly  1152 RQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            :|.::.|.|||.|||||:|..|.:|||||||.:||||..||:
Human   992 KQREQPEMVFRQFLVEDKGLYGGSSYVDFLCCVHKEICQLLN 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	53/215 (25%)
		COG5028	395..1190	CDD:227361	386/799 (48%)
SEC24D	NP_001304995.1	PHA03247	<8..294	CDD:223021	122/462 (26%)
		COG5028	182..1028	CDD:227361	420/934 (45%)
		Zinc finger-like	364..389		17/24 (71%)
		Gelsolin-like. /evidence=ECO:0000255	902..975		23/73 (32%)