Protein Alignment Sec24CD and SFB3

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: NP_011966.1
• Gene: SFB3 / 856498
• SGDID: S000001140
• Length: 929
• Species: Saccharomyces cerevisiae
• Alignment Length: 909
• Identity: 242/909 - (26%)
• Similarity: 416/909 - (45%)
• Gaps: 101/909 - (11%)

  Fly   348 PQPGYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNM 412
            |...|.....|..|..|..|..  .||..||.|.    .||.|..|.|.|  |||.    |:|::
Yeast    34 PHRAYHNFSSGTVPTLGNSPYT--TPQLNQQDGF----QQPQAFTPKQFG--GFNN----GSGSV 86

  Fly   413 YQ---------------QAPQARRLDPDQMPNPIQVMIENQRLSG------GPFVTNQPGLLPPL 456
            ..               .:|..:.:.....|.|...::..||...      ..|.|.:.. :|||
Yeast    87 MSTPVMVSQERFGASEASSPYGQSMLDMTAPQPTSHIVPTQRFEDQAQYLQRSFETCRDS-VPPL 150

  Fly   457 VTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMG 521
            .||:|...|||:..|..:..|:|.||.:..|...|.|||.|.|.|.:.:...:.|.|.:.....|
Yeast   151 PTTQFYCVDQGSCDPHLMSLSMYNIPESEHLRAATKLPLGLTIQPFSTLTPNDAEVPTIPLPMDG 215

  Fly   522 -PIRCNRCKAYMSPNMQFV-DAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTY 584
             |:||.||:||.:|..||. |:.  ..|.:|:|..:|...::..:...|||.|.:|:.|||.||.
Yeast   216 TPLRCRRCRAYANPKFQFTYDSS--VICNICRVKMQVPGEHFAPMGPNGQRSDLNEKSELLHGTV 278

  Fly   585 EFLATKDYCRNNTPPEVPA-FIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVG 648
            :||....|........:|. ::|:||||....::|....:...:::.::::    ...:....|.
Yeast   279 DFLVPSIYNAIQEKELLPLHYVFLIDVSLLANENGSSLAMVEGVRSCIEYI----SDFQPNCEVA 339

  Fly   649 FITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTK 713
            .|.|::.:.|:|::..|...|..:|.::.::|:|..:|....|..|..:|:..:.:|....:..|
Yeast   340 IIVYDNKLRFFNLRPDLDNAQEYIVSELDDVFLPFYNGLFVKPGNSMKIINDTLIKISGYISTDK 404

  Fly   714 ETET--ILY-PAIQAGLEALK--ASNAAGKLLVFNSTLP-IAEAPGKLKNRDDRKLLGTDKEKTV 772
            .:..  :.| .|:||...||.  .....||::...::|| |......|| ||:..:.....:...
Yeast   405 YSHVPQVCYGSALQAAKLALDTVTGGQGGKIICSLNSLPTIGNGNLSLK-RDNAHIAHVKCDNGF 468

  Fly   773 LTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQ 837
                   |..|..:.::...|:||:|.|..:||:||:|....:|.|.:..|.:||.:.|...|:.
Yeast   469 -------YKKLASDFLKSYISLDLYVTNAGFIDMATVGHPVEMTSGILKYYPHFQQETDAFTLVN 526

  Fly   838 DIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTD----VELASIDATKSISIEIKHDDK 898
            |::.|||..:.:.|:::||.|.|:...::|..  .|:.||    :.:.:.|.|  :.:.:|:|.|
Yeast   527 DMVTNVSNIVGYQALLKVRCSTGLSVEQYYCD--SSDNTDHDPIIPVLTRDTT--LDVLLKYDSK 587

  Fly   899 LAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHS 963
            :....:|:.|.|||||...|.|::|.:|.:..|:..|.::||..:.:.:|....|.....|.:..
Yeast   588 IKTGTDVHFQTALLYTDIDGVRKVRSINTSGAVSNNIREIFKFINQNPVMRIMIKDVIKTLGDCD 652

  Fly   964 PKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDMTL-DD 1027
            ..:::..:..:..:||..|| ...|..|:.|||||:.:|.||.|.....|::.:...:..|. ::
Yeast   653 FVKIRRLIDDKMVEILTQYR-GLVSSNSSTQLILPDSIKTLPAYMLAFEKSELMKPNAQSTRGNE 716

  Fly  1028 RSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLP------------------TPVRCTHEK 1074
            |.|.:....|::..|....|||:.:|.| |:.|||||.                  ..||.:|..
Yeast   717 RIYDLLKYDSLNSAQLCYKLYPQIVPFH-VLLEETDLTFYDANDKLLQINSSSINNLSVRASHSN 780

  Fly  1075 TQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQ---GLQQIALERFN-IVPE--TPLAKRIHG 1133
            ....|.|::..|..:::|..:..:...:|.:..|.   .:.||:|  |: .:||  |.:.::...
Yeast   781 FINGGCYLIFQGDTIYLWFNENTNRMLLQDLLSVDESLPVSQISL--FSGTLPETGTSINQKASN 843

  Fly  1134 IL---EQIMKERSRYMRITWLRQN-DKLES-VFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLL 1192
            ::   :|::.:.|  :.:..||.| |:..| |....|.||:..:...||.::|..|||:|::.|
Yeast   844 VIKNWQQVVNKSS--LPLVLLRPNVDQYYSNVMSQLLCEDKTVNRIESYDNYLVIMHKKIQEKL 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241
		COG5028	395..1190	CDD:227361	226/858 (26%)
SFB3	NP_011966.1	COG5028	1..903	CDD:227361	241/905 (27%)