DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and SFB3

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_011966.1	Gene:	SFB3 / 856498	SGDID:	S000001140	Length:	929	Species:	Saccharomyces cerevisiae

Alignment Length:	909	Identity:	242/909 - (26%)
Similarity:	416/909 - (45%)	Gaps:	101/909 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 PQPGYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNM 412
            |...|.....|..|..|..|..  .||..||.|.    .||.|..|.|.|  |||.    |:|::
Yeast    34 PHRAYHNFSSGTVPTLGNSPYT--TPQLNQQDGF----QQPQAFTPKQFG--GFNN----GSGSV 86

  Fly   413 YQ---------------QAPQARRLDPDQMPNPIQVMIENQRLSG------GPFVTNQPGLLPPL 456
            ..               .:|..:.:.....|.|...::..||...      ..|.|.:.. :|||
Yeast    87 MSTPVMVSQERFGASEASSPYGQSMLDMTAPQPTSHIVPTQRFEDQAQYLQRSFETCRDS-VPPL 150

  Fly   457 VTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMG 521
            .||:|...|||:..|..:..|:|.||.:..|...|.|||.|.|.|.:.:...:.|.|.:.....|
Yeast   151 PTTQFYCVDQGSCDPHLMSLSMYNIPESEHLRAATKLPLGLTIQPFSTLTPNDAEVPTIPLPMDG 215

  Fly   522 -PIRCNRCKAYMSPNMQFV-DAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTY 584
             |:||.||:||.:|..||. |:.  ..|.:|:|..:|...::..:...|||.|.:|:.|||.||.
Yeast   216 TPLRCRRCRAYANPKFQFTYDSS--VICNICRVKMQVPGEHFAPMGPNGQRSDLNEKSELLHGTV 278

  Fly   585 EFLATKDYCRNNTPPEVPA-FIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVG 648
            :||....|........:|. ::|:||||....::|....:...:::.::::    ...:....|.
Yeast   279 DFLVPSIYNAIQEKELLPLHYVFLIDVSLLANENGSSLAMVEGVRSCIEYI----SDFQPNCEVA 339

  Fly   649 FITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTK 713
            .|.|::.:.|:|::..|...|..:|.::.::|:|..:|....|..|..:|:..:.:|....:..|
Yeast   340 IIVYDNKLRFFNLRPDLDNAQEYIVSELDDVFLPFYNGLFVKPGNSMKIINDTLIKISGYISTDK 404

  Fly   714 ETET--ILY-PAIQAGLEALK--ASNAAGKLLVFNSTLP-IAEAPGKLKNRDDRKLLGTDKEKTV 772
            .:..  :.| .|:||...||.  .....||::...::|| |......|| ||:..:.....:...
Yeast   405 YSHVPQVCYGSALQAAKLALDTVTGGQGGKIICSLNSLPTIGNGNLSLK-RDNAHIAHVKCDNGF 468

  Fly   773 LTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQ 837
                   |..|..:.::...|:||:|.|..:||:||:|....:|.|.:..|.:||.:.|...|:.
Yeast   469 -------YKKLASDFLKSYISLDLYVTNAGFIDMATVGHPVEMTSGILKYYPHFQQETDAFTLVN 526

  Fly   838 DIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTD----VELASIDATKSISIEIKHDDK 898
            |::.|||..:.:.|:::||.|.|:...::|..  .|:.||    :.:.:.|.|  :.:.:|:|.|
Yeast   527 DMVTNVSNIVGYQALLKVRCSTGLSVEQYYCD--SSDNTDHDPIIPVLTRDTT--LDVLLKYDSK 587

  Fly   899 LAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHS 963
            :....:|:.|.|||||...|.|::|.:|.:..|:..|.::||..:.:.:|....|.....|.:..
Yeast   588 IKTGTDVHFQTALLYTDIDGVRKVRSINTSGAVSNNIREIFKFINQNPVMRIMIKDVIKTLGDCD 652

  Fly   964 PKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDMTL-DD 1027
            ..:::..:..:..:||..|| ...|..|:.|||||:.:|.||.|.....|::.:...:..|. ::
Yeast   653 FVKIRRLIDDKMVEILTQYR-GLVSSNSSTQLILPDSIKTLPAYMLAFEKSELMKPNAQSTRGNE 716

  Fly  1028 RSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLP------------------TPVRCTHEK 1074
            |.|.:....|::..|....|||:.:|.| |:.|||||.                  ..||.:|..
Yeast   717 RIYDLLKYDSLNSAQLCYKLYPQIVPFH-VLLEETDLTFYDANDKLLQINSSSINNLSVRASHSN 780

  Fly  1075 TQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQ---GLQQIALERFN-IVPE--TPLAKRIHG 1133
            ....|.|::..|..:::|..:..:...:|.:..|.   .:.||:|  |: .:||  |.:.::...
Yeast   781 FINGGCYLIFQGDTIYLWFNENTNRMLLQDLLSVDESLPVSQISL--FSGTLPETGTSINQKASN 843

  Fly  1134 IL---EQIMKERSRYMRITWLRQN-DKLES-VFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLL 1192
            ::   :|::.:.|  :.:..||.| |:..| |....|.||:..:...||.::|..|||:|::.|
Yeast   844 VIKNWQQVVNKSS--LPLVLLRPNVDQYYSNVMSQLLCEDKTVNRIESYDNYLVIMHKKIQEKL 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	226/858 (26%)
		zf-Sec23_Sec24	522..559	CDD:282641	15/37 (41%)
		Sec24-like	599..847	CDD:238756	61/254 (24%)
		Sec23_BS	848..932	CDD:285301	25/87 (29%)
		Sec23_helical	950..1043	CDD:282646	22/93 (24%)
		Gelsolin	1061..1135	CDD:279020	20/97 (21%)
SFB3	NP_011966.1	COG5028	1..903	CDD:227361	241/905 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3615
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoFinder	1	1.000	-	-		FOG0001889
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101536
Panther	1	1.100	-	-	LDO	PTHR13803
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1423
TreeFam	1	0.960	-	-
	11	10.710