DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and ERMO2

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_187366.2	Gene:	ERMO2 / 819896	AraportID:	AT3G07100	Length:	1038	Species:	Arabidopsis thaliana

Alignment Length:	1139	Identity:	359/1139 - (31%)
Similarity:	568/1139 - (49%)	Gaps:	157/1139 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PLKPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSV 161
            |..|..|..:|.|:||||                      |.||  |:|.      ||:.   |.
plant     9 PNFPARPASSPFASAPPP----------------------GIPP--QSGG------PPTG---SE 40

  Fly   162 ASGINQMSLNSATLAGLPHMPPPKAAT-PGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQI 225
            |.|..            |..|.....| |..|.|.||.|..|:..    ||||     .||..||
plant    41 AVGFR------------PFTPSASQPTRPFTASGPPPAPPVGTMR----PGQP-----SPFVSQI 84

  Fly   226 PTSQPAPSPYGVPSSR--PGQPQLPPGATP-PTYTQPGLPPQQQ--QGIPPLQQPGIPQQQPGFP 285
            |.|:|.|     |||.  |.....|||..| ..:..|..|..|.  ||.||      ||...|..
plant    85 PGSRPPP-----PSSNSFPSPAYGPPGGAPFQRFPSPPFPTTQNPPQGPPP------PQTLAGHL 138

  Fly   286 PQQPGLPPLSQPGLPPQPGAP--YGAPQQGGYSGGFPGQAPGGFPGAP----PPLPGQQAAAPPQ 344
            .     ||:|.  .|.||.||  .|.|.|...| |.||  ...:|.|.    |..||.|.:.||
plant   139 S-----PPMSL--RPQQPMAPVAMGPPPQSTTS-GLPG--ANAYPPATDYHMPARPGFQQSMPP- 192

  Fly   345 FGAPQPGYP---GQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPM 406
               ..|.||   |.||.:|..|.:|.:..  |.|.|...||..|| |.:.:|...|  ||.|.|
plant   193 ---VTPSYPGVGGSQPSFPGYPSKQVLQA--PTPFQTSQGPPGPP-PVSSYPPHTG--GFAQRP- 248

  Fly   407 PGAGNMYQQAPQARRLDPDQMPNP--IQVMIEN-QRLSGGPFVTNQPGLLPPLVTTK-------- 460
                ||..|    :.|.|:..|.|  :|.:.|: ..||    :::.||.|.|.:..|
plant   249 ----NMAAQ----QNLHPNYAPPPSNVQGLTEDFNSLS----LSSIPGSLEPGLDHKSFPRPLDG 301

  Fly   461 ------FVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGE 519
                  |......|...|:||.:...|||:..|.....|||...:.|||:..||| |.|:::||.
plant   302 DVEPNSFAEMYPMNCHSRYLRLTTSAIPNSQSLASRWHLPLGAVVCPLAETPEGE-EVPLIDFGS 365

  Fly   520 MGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTY 584
            .|.|||.||:.|::|.:.|.|:||:::|.:|.:.::|...|:.|||.||:|:|..:||||..|:.
plant   366 TGIIRCRRCRTYVNPFVTFTDSGRKWRCNICSMLNDVPGEYFSHLDATGRRMDMDQRPELTKGSV 430

  Fly   585 EFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGF 649
            |.:|..:|...  ||..|.:.|:||||.:..|||::.::...||:.|.:||     ...:.::||
plant   431 EIIAPTEYMVR--PPMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLP-----GYPRTQIGF 488

  Fly   650 ITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKE 714
            |||:||:||||:||||:|||||||.|:.::|:||.|..|.:..||..|:||.::.:|.||.|...
plant   489 ITYDSTLHFYNMKSSLSQPQMMVVSDLDDIFVPLPDDLLVNLSESRTVVDAFLDSLPLMFQDNFN 553

  Fly   715 TETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNR-DDRKLLGTDKEKTVLTPQTT 778
            .|:...||::|....:  :...||||:|.::||...| |:||.| ||.::.|||||..:...:..
plant   554 VESAFGPALRAAFMVM--NQLGGKLLIFQNSLPSLGA-GRLKLRGDDPRVYGTDKEYALRVAEDP 615

  Fly   779 AYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNV 843
            .|..:..:|.:....::::.|::.|.|:|::|.:::.|||:|:.|..||:.|.|.:|..::.:::
plant   616 FYKQMAADCTKFQIGINVYAFSDKYTDIASLGTLAKYTGGQVYYYPGFQSSVHGDKLRHELARDL 680

  Fly   844 SRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQ 908
            :|..|::||||:|...|||.:.::|:|.:.:|..:.|.::|..|:.::::..::.|...:.||.|
plant   681 TRETAWEAVMRIRCGKGIRFSSYHGNFMLRSTDLLALPAVDCDKAYAMQLSLEETLLTSQTVYFQ 745

  Fly   909 VALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIH 973
            ||||||:..|:||:|:......|.|.:.::::..|..:::..:|:.|..|.:.......::.:..
plant   746 VALLYTASCGERRIRVHTSVAPVVTDLGEMYRQADTGSIVSLYARLAIEKSLSAKLDDARNAIQQ 810

  Fly   974 RSAQILACYRK-HCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGG-SDMTLDDRSYVIQFIL 1036
            :..:.|..||. |........:|:.||.||.||||...:.|:..:.|| :|.:||:|......::
plant   811 KIVKALKEYRNLHAVQHRLGSRLVYPESLKFLPLYGLAITKSTPLLGGPADTSLDERCAAGFTMM 875

  Fly  1037 SMDLNQSVSYLYPRFIPIHNVVPEET-------DLPTPVRCTHEKTQEDGAYILENGVHLFVWLG 1094
            ::.:.:.:..|||....:...:.:.:       |:...:....|.....|.||.::|..|.:|.|
plant   876 ALPVKKLLKLLYPNLFRVDEWLLKPSAAHDDFKDVLRRLPLAAESLDSRGLYIYDDGFRLVLWFG 940

  Fly  1095 QALSPDFVQSVFGVQGLQQIALERFNIVPETPLAKRIHGILEQIMKERSRYMRITWL-RQNDKLE 1158
            :.||||..:::.||.....::...|. ..|..::|::..:::::.:....|..:.:| ||.::..
plant   941 RMLSPDIAKNLLGVDFAADLSRVTFQ-EQENGMSKKLMRLVKKLRESDPSYHPMCFLVRQGEQPR 1004

  Fly  1159 SVF---RHFLVEDRGTDGSASYVDFLCHMHKEIK 1189
            ..|   |: |:||: ..||:.|||::..:|::::
plant  1005 EGFLLLRN-LIEDQ-MGGSSGYVDWILQLHRQVQ 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	259/826 (31%)
		zf-Sec23_Sec24	522..559	CDD:282641	14/36 (39%)
		Sec24-like	599..847	CDD:238756	93/248 (38%)
		Sec23_BS	848..932	CDD:285301	29/83 (35%)
		Sec23_helical	950..1043	CDD:282646	23/94 (24%)
		Gelsolin	1061..1135	CDD:279020	18/80 (23%)
ERMO2	NP_187366.2	PHA03247	<2..324	CDD:223021	126/411 (31%)
ERMO2	NP_187366.2	COG5028	167..1036	CDD:227361	287/906 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1051
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820