DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and Sec24a

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_780464.2	Gene:	Sec24a / 77371	MGIID:	1924621	Length:	1090	Species:	Mus musculus

Alignment Length:	1207	Identity:	343/1207 - (28%)
Similarity:	547/1207 - (45%)	Gaps:	207/1207 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QPQYGAPPPTSAASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFN 118
            |.|.||   .||:..||.||...                   |.|..|....:....:.||
Mouse    17 QAQNGA---ASASGSPYTNGPVH-------------------NTLMSPQVSSSQGYDSQPP---- 55

  Fly   119 QFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQS--VASGINQMSLNSATLAGLPHM 181
              .|...|.|....|       |..|.|...|:.....|..|  |.||....||:|..   :|.|
Mouse    56 --GSYPRPMPAKTLN-------PFSAQSNYGGSQGSGQTLNSPLVTSGPVLPSLHSGP---VPRM 108

  Fly   182 PPPKAATPGAAPGQPPIPAAGSTSQPPLPG-QPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQP 245
            |.|.:..|.|.    |:| :||.    ||| .||    ||.:.|          |..||:.|...
Mouse   109 PLPTSQNPAAT----PMP-SGSF----LPGANPP----PPLNWQ----------YNYPSTGPQTN 150

  Fly   246 QLPPGATPPTYTQPGLPPQQQ---QGIPPLQ----QPGIPQQQPGFPPQQPGLPPLSQPGLPPQP 303
            ..|..|.|.....|.|....|   .|.|.||    :||     ...|.|.|.|||..|||.||
Mouse   151 HFPHVAPPTLPGNPNLTADHQYVSSGDPALQTSFKKPG-----SALPLQNPPLPPTFQPGAPP-- 208

  Fly   304 GAPYGAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGA--------------------- 347
                |.|..||     |..:.|..|...||    :||.||.|.:
Mouse   209 ----GPPPAGG-----PPPSRGPAPQKTPP----RAAPPPSFNSAVNQEGITSNANNGSTAAHNT 260

  Fly   348 ------------PQ-------------PGYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQ 387
                        ||             ..||...|||  |....|:.|.||
Mouse   261 YDEIEGGGFLATPQLVNQNPKTSRSVGSAYPSLPPGY--QNSAPPVAGMPP-------------- 309

  Fly   388 PGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQVMIENQRLSGGPFVTNQPGL 452
            |...:|..|  ..|.|.|: || |....:.....|.|:.: ..:.::.|...|...|.....|.|
Mouse   310 PSLSYPSGP--QAFTQTPL-GA-NHLTASMSGLSLHPEGL-RVVNLLQERNMLPSTPLQPPVPNL 369

  Fly   453 LPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNF 517
            |..:        .:.|.:|...|.:|..:|.|..||....|||.|.:.|...:    ::.|:|..
Mouse   370 LEDI--------QKLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDL----VQLPVVTS 422

  Fly   518 GEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNY-YQHLDHTGQRV--DKHERPEL 579
            ..:  :||..|:.|::|.:.|:|. ||::|.:|...::|.:.: |..|    .||  :.|:|||:
Mouse   423 STI--VRCRSCRTYINPFVNFLDQ-RRWKCNLCYRVNDVPEEFMYNPL----TRVYGEPHKRPEV 480

  Fly   580 LLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSK 644
            ...|.||:|..:|...  ||:.|.::|:.|||:|.:::|.::.:|..:.:.|..||     ..::
Mouse   481 QNATIEFMAPSEYMLR--PPQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLP-----GNTR 538

  Fly   645 VRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMF 709
            .::||||::||:|||:::..|:||||::|.|:.::|:|:.:..|.:..||..::..|::.:|:||
Mouse   539 TKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPMPENLLVNLNESKELVQDLLKTLPQMF 603

  Fly   710 ADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLT 774
            ..|.||::.|.||:||..:.:  |...|::.||.:.||.. ..|.||.|::.....:.|| ..||
Mouse   604 TKTLETQSALGPALQAAFKLI--SPTGGRMSVFQTQLPTL-GVGALKPREEPNQRSSAKE-IHLT 664

  Fly   775 PQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQAD---VDGKRLI 836
            |.|..|..|..:|..|..:||||:.:..|.|||::|.:||.:.|.|:.|..:...   |..::|.
Mouse   665 PSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQ 729

  Fly   837 QDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAP 901
            :::.:.::|.|.|:||||:|.:.|:....|:|:||:.:|..:.|.:::.....::::..::.|..
Mouse   730 KELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTD 794

  Fly   902 EENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQ 966
            .:.|..|.||||||..|:||:|:..|.|.|.:|:.:||...|:.|:....|..|..:.:..|...
Mouse   795 TQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLANMAVDRSVTASLSD 859

  Fly   967 VKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYV 1031
            .:|.|::.....|:.||....|....| |::|..|:|.||:...|||..:...|:.:.||:|.:.
Mouse   860 ARDALVNAVIDSLSAYRSSVLSGQQPG-LMVPFSLRLFPLFVLALLKQKSFQTGTSIRLDERIFA 923

  Fly  1032 IQFILSMDLNQSVSYLYPRFIPIHNVVPE------ETDLPTP--VRCTHEKTQEDGAYILENGVH 1088
            :..:.|..|...:...:|....:.|:..|      :..:|.|  ::.:.||...|||::::.|..
Mouse   924 MCQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTIPQPPILQLSVEKLSRDGAFLMDAGSL 988

  Fly  1089 LFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPE--TPLAKRIHGILEQIMKERSRYMRITWL 1151
            |.:|:|:..|.:|:..|.|||....|. :....:||  ||.:.||...:..:.::|..:..:..:
Mouse   989 LMLWVGRNCSQNFLSQVLGVQNYASIP-QTMTDLPELDTPESARIAAFISWLREQRPFFPVLYVI 1052

  Fly  1152 RQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEI 1188
            |:...:::.|...||||| |:.:.||.:||.|:.:::
Mouse  1053 REESLMKAAFLQSLVEDR-TESALSYYEFLLHIQQQV 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	239/810 (30%)
		zf-Sec23_Sec24	522..559	CDD:282641	12/36 (33%)
		Sec24-like	599..847	CDD:238756	82/250 (33%)
		Sec23_BS	848..932	CDD:285301	28/83 (34%)
		Sec23_helical	950..1043	CDD:282646	25/92 (27%)
		Gelsolin	1061..1135	CDD:279020	24/77 (31%)
Sec24a	NP_780464.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..260		90/323 (28%)
		SSDP	7..>177	CDD:282372	59/220 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..325		17/70 (24%)
		zf-Sec23_Sec24	425..461	CDD:282641	12/38 (32%)
		Zinc finger-like	428..452		9/24 (38%)
		Sec24-like	498..740	CDD:238756	82/250 (33%)
		Sec23_BS	741..825	CDD:285301	28/83 (34%)
		Sec23_helical	840..935	CDD:282646	25/95 (26%)
		Gelsolin	961..1036	CDD:279020	24/75 (32%)
		Gelsolin-like. /evidence=ECO:0000255	963..1036		24/73 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820