Protein Alignment Sec24CD and sec24c

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: XP_031760998.1
• Gene: sec24c / 733829
• XenbaseID: XB-GENE-1003364
• Length: 1184
• Species: Xenopus tropicalis
• Alignment Length: 1254
• Identity: 551/1254 - (43%)
• Similarity: 739/1254 - (58%)
• Gaps: 173/1254 - (13%)

  Fly    39 QQP--PQQQLPPQQ-QQQQPQYGAPPPTSAASQPYLNGNYQ--QQLATSMGGLSVGGGVGGANPL 98
            |||  ....:.||. ..|||.|...|.:.....|..||:.|  .|...:.|.||..|     .|:
 Frog     5 QQPHISTSYMQPQPGSYQQPVYAGQPISGGPQYPGYNGSLQGYSQHTPTQGFLSSSG-----FPV 64

  Fly    99 KPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTN----NNNAAFGAPPPTQAGSYVNGALPPSSTPQ 159
            |     |:|          :.|.|..:.|.|:    ::....||||.:.|.:....:||   ..|
 Frog    65 K-----GSP----------DSFTSGTSSPITSDYLGHHGNLMGAPPVSAAPTIAGQSLP---AEQ 111

  Fly   160 SVASGINQMSLNSATLAGLPHMPP-----------PKAA-----TPGAA---------------- 192
            .:.|...|..:::..:......||           |:||     ||.:|
 Frog   112 ELYSQYGQGDIHNGPVTNQMQRPPVSMRYMQPGTGPQAASFQPYTPSSASAQQQQLTNQMMGMQI 176

  Fly   193 -------------------PGQPP---IPAAGSTSQPPL---PGQPPL---PGQPPFSGQIPTSQ 229
                               |.||.   .|.|||..||..   .|.||:   .|.||.|  :|.||
 Frog   177 GNIAASTPTSTAMGYGSQNPLQPSSGNFPTAGSGFQPSYSNSQGPPPINLTQGMPPTS--LPQSQ 239

  Fly   230 P-------APSPYGVPSSR-PGQPQLPPGAT--PPTYTQPGLPPQQ--QQGIPPLQQPGIPQQQP 282
            |       .|.|..:|||: ||.|  ||.|.  ||:|..|...|||  .|| |||....:|
 Frog   240 PPQQRFASGPPPQNLPSSQAPGFP--PPSAAQMPPSYVSPSGGPQQPVTQG-PPLSGQALP---- 297

  Fly   283 GFPPQQPGLPPLSQPGL-----PPQPGAPYGAPQQGGYSGGFPGQAPGGFPGAPPP-LPGQQAAA 341
                    .|||:.|.|     ||.||.|. .|...|             |..||| :|..|...
 Frog   298 --------APPLAHPNLASPTQPPMPGVPL-IPTMTG-------------PQGPPPHMPSSQDGF 340

  Fly   342 PPQFGA------PQPGYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPG 400
            ..|.|:      ||||||...|         ..|.|..|||.|  ||..||.|.   |.:...|
 Frog   341 SQQNGSFGQVKGPQPGYPVTYP---------RAPNYGSQPGLQ--GPPAPPPPA---PQKRLDP- 390

  Fly   401 FNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQVMIENQRLSGG-PFVTNQPGLLPPLVTTKFVVH 464
             :..|.|.|..:..|.....|:|||.:|:||||:.:::...|. ||:|.|.|.:|||:||..:|.
 Frog   391 -DSIPSPQANELPPQQKTRHRIDPDAIPSPIQVIEDDKNNRGSEPFITGQRGQVPPLITTNVLVK 454

  Fly   465 DQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCK 529
            ||||:|||::|.:.|..|.:.|:.|.:.:||...|.|||.:...|:.|.:|:.||.|||||||||
 Frog   455 DQGNTSPRYIRCTSYNFPASSDMAKQSQVPLAAVIKPLATLPPDELPPFLVDHGETGPIRCNRCK 519

  Fly   530 AYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCR 594
            |||.|.|||::.||||||..|...:||..:|:|||||||:|||.:|||||.:|:|||.||.|||:
 Frog   520 AYMCPFMQFIEGGRRFQCCFCSCVTEVPTHYFQHLDHTGRRVDCYERPELSMGSYEFTATVDYCK 584

  Fly   595 NNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFY 659
            ||..|..|||||:||||||.||||||.|:|.::|.::.:||.:...::|.:||||:|||..:|||
 Frog   585 NNKTPNPPAFIFMIDVSYNAVKSGLVALVCEELKQLVDYLPREGSMEESVIRVGFVTYNKVLHFY 649

  Fly   660 NIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQ 724
            |:||||||||||||.||.:||:|||||||.:..||..||::|:::||.:||||:||||:..|.||
 Frog   650 NVKSSLAQPQMMVVSDVSDMFVPLLDGFLVNVNESRTVINSLLDQIPELFADTRETETVFAPVIQ 714

  Fly   725 AGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQ 789
            ||||||||::.||||.:|::||||||||||||||||:||:.|||||.:..|||..||.|.::||.
 Frog   715 AGLEALKAADCAGKLFIFHTTLPIAEAPGKLKNRDDKKLVNTDKEKILFQPQTNFYNNLSKDCVA 779

  Fly   790 QGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMR 854
            |||.||||:|.|.::|:||:|.|...|||.|:|||:||.:.|.:|.:.|:.::|.:.|.||||||
 Frog   780 QGCCVDLFLFPNQFLDVATLGVVPFQTGGSVYKYTFFQPETDKERFLNDLRRDVQKEIGFDAVMR 844

  Fly   855 VRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQ 919
            ||||.|||.|:|:|.|:||||||||||.:|..|:|::|.||||||..:....||.|:|||||.||
 Frog   845 VRTSTGIRATDFFGAFYMSNTTDVELAGLDCDKTITVEFKHDDKLNEDTGALLQCAILYTSCGGQ 909

  Fly   920 RRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRK 984
            ||||:.|:||...|.:||:::.|:.|.::.:|||.|...::.:..|.|:|.||::.|||||||||
 Frog   910 RRLRVHNMALNCCTQLADLYRNCETDTLINYFAKFAFRGVLSNPTKTVRDTLINQCAQILACYRK 974

  Fly   985 HCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYP 1049
            :|.||:||||||||||:||||:|.:|:||:|.:..|::||:|||:|:.|.:.|||:..|..:.||
 Frog   975 NCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEMTIDDRTYIRQLVSSMDVADSNVFFYP 1039

  Fly  1050 RFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQI 1114
            |.:|:..:.|....||..:|.:.|:..:...|:||||::||||:|..:....:|::|.|....||
 Frog  1040 RLLPLSKMDPSNDSLPVAIRSSEERLSKGEMYLLENGLNLFVWVGANIQQSLIQNLFNVSSFSQI 1104

  Fly  1115 -----ALERFNIVPETPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGS 1174
                 ||.    |.:.|::.:|.||:.....:|.|||::..::|:||:|.:|:|.||||:..:|.
 Frog  1105 DSSMSALP----VLDNPISNKIRGIITMFRAQRPRYMKLIIVKQDDKIEMLFKHLLVEDKNLNGG 1165

  Fly  1175 ASYVDFLCHMHKEIKDLLS 1193
            ||||||||||||||:.|||
 Frog  1166 ASYVDFLCHMHKEIRQLLS 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	78/282 (28%)
		COG5028	395..1190	CDD:227361	420/800 (53%)
sec24c	XP_031760998.1	Atrophin-1	10..>396	CDD:460830	127/455 (28%)
		COG5028	303..1180	CDD:227361	455/910 (50%)