Protein Alignment Sec24CD and Sec24d

DIOPT Version :9

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: NP_081411.2
• Gene: Sec24d / 69608
• MGIID: 1916858
• Length: 1032
• Species: Mus musculus
• Alignment Length: 1215
• Identity: 492/1215 - (40%)
• Similarity: 682/1215 - (56%)
• Gaps: 205/1215 - (16%)

  Fly     1 MNPNMYGPPPTQFQQQPQFGAPPPNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSA 65
            |:...|...|...|.||..|..||:.|                            .||  .|:.|
Mouse     1 MSQQGYVATPPYSQSQPGMGISPPHYG----------------------------HYG--DPSHA 35

  Fly    66 ASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPP---PTGFNQFNSNAAPP 127
            :|.|                     ||     :||..|..||:...||   |.|..||..|.|..
Mouse    36 SSPP---------------------GV-----MKPLGPSAAPSGMLPPGPLPPGPPQFGPNGAHT 74

  Fly   128 PTNNNNAAFGAPPPTQ--AGSYVNG-ALPPSSTP--------QSVASGINQMSLNSATLAGLPHM 181
            | .:....|..|||..  |.||.:| .||.||.|        ..:.|..:.|.:||..:...|.
Mouse    75 P-GHPPQRFPGPPPVNSVAPSYASGQTLPQSSYPGPGSTSSVTQLGSQFSSMQINSYGVGATPQ- 137

  Fly   182 PPPKAATPGAAPGQPPIPAAGSTSQPPLPGQPPL--PGQPPFSGQIPTSQPAPSPYGVPSSRPGQ 244
                      :.|.|...:||:...||.|.||.:  ||.     |:|  .|.|:....|.:.|
Mouse   138 ----------SQGPPGPQSAGAFQGPPQPAQPSILQPGH-----QVP--PPPPTALNGPGASP-- 183

  Fly   245 PQLPPGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGA 309
                  .:|||:.|.|||     |..||.    .|.||..||.|     ...||.|||....||
Mouse   184 ------MSPPTHRQDGLP-----GPAPLN----AQYQPPPPPGQ-----TLGPGYPPQQATNYG- 227

  Fly   310 PQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQQPMPGYPPQ 374
            ||.||....:    ||||||.|
Mouse   228 PQMGGAQMSY----PGGFPGGP------------------------------------------- 245

  Fly   375 PGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQ-ARRLDPDQMPNPIQVMIENQ 438
              .|:.||                                 ||| .|:||||.:|:|||| |||.
Mouse   246 --AQMAGP---------------------------------APQLQRKLDPDSIPSPIQV-IEND 274

  Fly   439 RLS--GGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISP 501
            |.:  |..:.||..|.:||||||:.|:.|||:||||::|.:.||.|.|.|:.|...:||...|.|
Mouse   275 RATRGGQVYTTNTRGQVPPLVTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAKQAQIPLAAVIKP 339

  Fly   502 LAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDH 566
            .|.:...|....:||.||.||:|||||||||.|.|||::.|||:||..|...:||...|:|||||
Mouse   340 FADIPPNETPLYLVNHGESGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPPFYFQHLDH 404

  Fly   567 TGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNIL 631
            .|:|:|.:|:|||.||:||::||.||||.|.||..|||||:|||||:.:|:|||.|:|.::|..|
Mouse   405 IGRRLDHYEKPELSLGSYEYVATLDYCRKNKPPSPPAFIFMIDVSYSNIKNGLVKLICEELKTAL 469

  Fly   632 KHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAA 696
            |.||.::.::.|.:||||||||..:||:|:||:|||||||||.||.|:|:|||||||.:.|||.:
Mouse   470 KRLPKEEHEETSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGEVFVPLLDGFLVNYEESQS 534

  Fly   697 VIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDR 761
            ||..|:::||.||||:.|.||:..|.||||:|||||:...|||.:|:|:||.||||||||||||:
Mouse   535 VIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHSSLPTAEAPGKLKNRDDK 599

  Fly   762 KLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYF 826
            ||:.|||||.:..|||..|.:|.::||...|||.||:|.:.::|:|::|.|..||||.::||..|
Mouse   600 KLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVF 664

  Fly   827 QADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISI 891
            |...|.:|.:.|:..::.:.|.|||:||||||.|.|.|:|:|..||:||||||:|:||..|::::
Mouse   665 QIHSDSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGIFMNNTTDVEMAAIDCDKAVTV 729

  Fly   892 EIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQAC 956
            |.||||||:.:....:|.|:|||:.||||||||.||||..:|.:||::|.|:.||::.||||.|
Mouse   730 EFKHDDKLSEDVGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSA- 793

  Fly   957 FKLMEHSP-KQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGG 1020
            ||.:.:.| |.:::.|::::|.:||||||||.||::|.|||||:.:|:||:|.:.||||..:...
Mouse   794 FKAVLNQPLKAIREILVNQTAHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVLLSR 858

  Fly  1021 SDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILEN 1085
            |:::.|:|:|..|.:::|.:..|..:.||..:|||.:..:...||..|||:..:..|:|.::|.|
Mouse   859 SEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTLDVKSAALPPAVRCSESRLSEEGIFLLAN 923

  Fly  1086 GVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPE--TPLAKRIHGILEQIMKERSRYMRI 1148
            |:::|:|.|....|:.:|.:|.|.....|..:..:: ||  :|.::::..|:..|.:::...|::
Mouse   924 GLNMFLWFGVGSPPELIQGIFNVPSFAHINTDMTSL-PEVGSPHSQQLRMIMNNIQQKKPYSMKL 987

  Fly  1149 TWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            ..::|.::.|..||.|||||:|..|.:|||||||.:||||..||:
Mouse   988 IVVKQREQREMAFRQFLVEDKGLYGGSSYVDFLCCVHKEICQLLN 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	386/800 (48%)
		zf-Sec23_Sec24	522..559	CDD:282641	22/36 (61%)
		Sec24-like	599..847	CDD:238756	135/247 (55%)
		Sec23_BS	848..932	CDD:285301	50/83 (60%)
		Sec23_helical	950..1043	CDD:282646	41/93 (44%)
		Gelsolin	1061..1135	CDD:279020	21/75 (28%)
Sec24d	NP_081411.2	COG5028	116..1027	CDD:227361	443/1036 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838000
Domainoid	1	1.000	321	1.000	Domainoid score	I1222
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	950	1.000	Inparanoid score	I342
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001889
OrthoInspector	1	1.000	-	-		otm42900
orthoMCL	1	0.900	-	-		OOG6_101536
Panther	1	1.100	-	-	O	PTHR13803
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1962
SonicParanoid	1	1.000	-	-		X1423
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790