DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and Sec24c

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	XP_006251718.1	Gene:	Sec24c / 685144	RGDID:	1597739	Length:	1118	Species:	Rattus norvegicus

Alignment Length:	1229	Identity:	554/1229 - (45%)
Similarity:	731/1229 - (59%)	Gaps:	147/1229 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNPNMYGPPPTQF-QQQPQF-GAPPPNSGGWP-PQQQQLPQ-----QQPPQQQLPPQQQQQQPQY 57
            ||.|...||...| |.||.: |....|.||.| |.....|.     ..|..||.|||...:.|..
  Rat     1 MNVNQSAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPC 65

  Fly    58 GAPPPTSAASQPYLNGNYQQQLATSMGGLSVGGG-------VGGANPLKPPLPQGAPAAAAP--- 112
            ...||.|||..|.....|.|   ...|.:..|..       |.|:....|||   ||..:.|
  Rat    66 SGAPPASAAQVPCGQTTYGQ---FGQGDIQNGPSSTAQMPRVPGSQQFGPPL---APVVSQPAVL 124

  Fly   113 PPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAG 177
            .|.|         ||||:....|      ..|...::||:..:..|                 :|
  Rat   125 QPYG---------PPPTSTQVTA------QLAAMQISGAVAQAPPP-----------------SG 157

  Fly   178 LPHMPPPK-AATPGAAPGQPPIPAAGSTSQPPL------PG-QPPLPGQPPFSGQIPTSQPAPSP 234
            |.:.||.. |:..|..|...|......:..|||      || ||||...||.:          |.
  Rat   158 LGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLA----------SS 212

  Fly   235 YGVPSSRPGQPQLPPGATPPTYTQPG-LPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPG 298
            :..|:|  |.|::|        :.|| |||.|..|..|:.|    ..:...||.. .|||.:|..
  Rat   213 FTSPAS--GGPRMP--------SMPGPLPPGQGFGSLPVSQ----ANRVSSPPAH-ALPPGTQMT 262

  Fly   299 LPPQPGAPYGAPQQGGY----SGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGY 359
            .||.|..|..:|||.||    :|.| |.|.|                      |||.|....||
  Rat   263 GPPAPPPPMHSPQQPGYQLQQNGSF-GPARG----------------------PQPNYESPYPG- 303

  Fly   360 PPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDP 424
                    .|.:..|||        ||||   .|  |.|...:..|.|....:..|.....|:||
  Rat   304 --------APTFGTQPG--------PPQP---LP--PKRLDPDAIPSPQLTELPPQQKTRHRIDP 347

  Fly   425 DQMPNPIQVMIENQRLSGG--PFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDL 487
            |.:|:|||| ||:.|.:.|  ||||...|.:||||||.|:|.||||:|||::|.:.|.||.|.|:
  Rat   348 DAIPSPIQV-IEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDM 411

  Fly   488 LKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKV 552
            .|...:||...|.|||::...|..|.:|:.||.||:|||||||||.|.|.|::.||||||..|..
  Rat   412 AKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSC 476

  Fly   553 TSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKS 617
            .::|...|:|||||||:|||.::||||.||:||||||.|||:||..|..|||||:||||||.:::
  Rat   477 INDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRT 541

  Fly   618 GLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMP 682
            |||.|||.::|::|.:||.:.|.::|.:||||:|||..:||||:||||||||||||.||.:||:|
  Rat   542 GLVRLLCEELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVP 606

  Fly   683 LLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLP 747
            ||||||.:..||.|||.:|:::||.|||||:||||:..|.||||:|||||:..||||.:|:::||
  Rat   607 LLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLP 671

  Fly   748 IAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQV 812
            ||||||||||||||||:.||||||:..|||..|.||.:|||.|||.||||:|.|.|:|:||:..|
  Rat   672 IAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVV 736

  Fly   813 SRLTGGEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTD 877
            .:||||.|:||..||.:.|.:|.:.|:.::|.:.:.||||||||||.|||..:|:|.|:||||||
  Rat   737 PQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTD 801

  Fly   878 VELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCC 942
            ||||.:|..|::::|.||||:|..|....||.|||||||:|||||||.||||...|.:||:::.|
  Rat   802 VELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNC 866

  Fly   943 DLDAMMLFFAKQACFKLMEHSP-KQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPL 1006
            :.|.::.:.||.| ::.:..|| |.|:|.||.:.|||||||||:|.||:||||||||||:||||:
  Rat   867 ETDTLINYMAKFA-YRAVVSSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPV 930

  Fly  1007 YASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCT 1071
            |.:|:||:|.:..|:::|.|||:||.|.:.|||:.::..:.|||.:|:.....:.|..|..||.:
  Rat   931 YLNCVLKSDVLQPGAEVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLTKSPLDSTTEPPAVRAS 995

  Fly  1072 HEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVP--ETPLAKRIHGI 1134
            .|:......|:||||::||||:|.::....|||:|.|....||. ...:::|  :.||:|::.|:
  Rat   996 EERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQIT-SGLSVLPVLDNPLSKKVRGL 1059

  Fly  1135 LEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            ::.:..:|:|||::..::|.||||.:|:||||||:...|.||||||||||||||:.|||
  Rat  1060 IDTLRAQRTRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	430/799 (54%)
		zf-Sec23_Sec24	522..559	CDD:282641	21/36 (58%)
		Sec24-like	599..847	CDD:238756	150/247 (61%)
		Sec23_BS	848..932	CDD:285301	55/83 (66%)
		Sec23_helical	950..1043	CDD:282646	52/93 (56%)
		Gelsolin	1061..1135	CDD:279020	27/75 (36%)
Sec24c	XP_006251718.1	PHA03247	<7..343	CDD:223021	123/443 (28%)
Sec24c	XP_006251718.1	COG5028	181..1114	CDD:227361	490/1005 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1190
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3615
Inparanoid	1	1.050	945	1.000	Inparanoid score	I322
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001889
OrthoInspector	1	1.000	-	-		otm44967
orthoMCL	1	0.900	-	-		OOG6_101536
Panther	1	1.100	-	-	LDO	PTHR13803
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1423
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830