DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and sec24c

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	XP_005156414.2	Gene:	sec24c / 571870	ZFINID:	ZDB-GENE-030131-4487	Length:	1300	Species:	Danio rerio

Alignment Length:	1343	Identity:	572/1343 - (42%)
Similarity:	775/1343 - (57%)	Gaps:	201/1343 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PNM---YGPPPTQFQQQPQFG-----------APPPNSG------GWPPQ-----------QQQL 36
            |:|   ||.|...:|:.||.|           .|.|..|      |:|.|           ||..
Zfish     7 PHMASPYGQPQPGYQRYPQPGYQRYPQPGYQRYPQPGYGGGHVPSGYPAQYAPDNGPGSGYQQGP 71

  Fly    37 PQ-------------------------------QQPPQQQLPP-------------QQQQQQPQY 57
            ||                               ::||....||             :.|...|..
Zfish    72 PQGYSPYASFPSKTLTTNLVSDLSSSSPLDLGMREPPTSGTPPVSGAQSYSQFGQGETQNGPPPM 136

  Fly    58 GAPPPTSAASQPY------LNGNYQ--------------QQLATSMGGLSVG------GGVGGAN 96
            .|||..:..|||:      |:|..|              ||:...|..:.||      .|.|.|
Zfish   137 VAPPQGTLVSQPHTPNAVSLSGPTQPPYGQQFGSPPIGMQQMTNQMASMQVGSTAPSPAGPGYA- 200

  Fly    97 PLKPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSY-----VNGALPPSS 156
               ||....||.:||..|         :|||.....::|...||||:|.:.     ..||.||:.
Zfish   201 ---PPSTAQAPISAAYTP---------SAPPTFPPTSSAPSQPPPTEAVAQPPPLPYYGAPPPAQ 253

  Fly   157 TPQSVASGINQMSLNSATLAGLPHMPPPKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPF 221
            .|..     |.:|..|:.....|..||        :..|...|.|.:.||||....||......:
Zfish   254 QPFP-----NAVSTFSSAGPTQPQAPP--------SVSQQSFPQAPAVSQPPFSTAPPPGPSQSY 305

  Fly   222 SGQIPTSQPAPSPYGVPSSRPGQPQLPPGATPPTYTQ---PG-LPPQQQQGIPPLQQPGIPQQQP 282
            .|.:|.:||:.....:|:|:||   :.||..|||.|.   || :|||     ||:.||.....:|
Zfish   306 GGPLPPTQPSFQRAPLPTSQPG---VFPGGPPPTSTHSQLPGPMPPQ-----PPVSQPSPYYSEP 362

  Fly   283 GFPPQQPGLPPLSQPGLPPQPGAPYGAPQQGGYSGGFPGQAPGGFPGA--PPPLPGQQAAAPPQF 345
              ||.....||  |.|.||:|  |....|....:...|..|..|.|||  .|||   |...|| .
Zfish   363 --PPTTASFPP--QVGAPPRP--PLAGMQGPPMASQGPLMASHGPPGASQEPPL---QLQGPP-M 417

  Fly   346 GAPQP------GYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYP------------PQPGAGF 392
            |:..|      ..|..|||.||.|....:.|.|||||.|    |||            ||||...
Zfish   418 GSQGPTMAQVNHVPPSQPGMPPGPINASLSGPPPQPGMQ----GYPPQQNGAFGQVRGPQPGYAA 478

  Fly   393 PGQPGRPGFNQP-------------------PMPGAGNMYQQAPQARRLDPDQMPNPIQVMIENQ 438
            |...|:|.:..|                   |.|...:|........|:|||.:|:|||| ||:.
Zfish   479 PPYSGQPNYGAPPAAPAPAPAAPKRLDPDSIPSPQTSDMPPVQKTRHRIDPDAIPSPIQV-IEDD 542

  Fly   439 RLSGG--PFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISP 501
            :.:.|  ||.|...|..||||||:|.|.||||:|||::|.:.|.:|...|:.|.:.:||...|.|
Zfish   543 KANKGSQPFTTGVRGQAPPLVTTRFQVKDQGNASPRYIRCTAYNMPCNSDMAKQSQVPLAAVIKP 607

  Fly   502 LAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDH 566
            ||.:...|..|.:|:.||.||||||||||||.|.|||::.||||||..|...:||..:|:|||||
Zfish   608 LATLPPDESPPYLVDHGESGPIRCNRCKAYMCPFMQFIEGGRRFQCGFCSCVTEVPPHYFQHLDH 672

  Fly   567 TGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNIL 631
            ||:|||.:|||||.:|:|||:||.|||:||..|:.|||||:||||||.||:|:|.::|.::|.::
Zfish   673 TGKRVDCYERPELSMGSYEFMATVDYCKNNKFPQPPAFIFLIDVSYNAVKNGMVGMVCQELKTLM 737

  Fly   632 KHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAA 696
            .:||.:....:|.|||||:|||..:||||:|:|||||||:||.||.:||:|||||||.:..||..
Zfish   738 DYLPRENPDVESNVRVGFVTYNKVLHFYNVKASLAQPQMLVVSDVADMFVPLLDGFLVNVSESRV 802

  Fly   697 VIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDR 761
            ||::|:::||.|||||:||||:..|.||||||||||::.||||.:|:|:|||||||||||||:|:
Zfish   803 VIESLLDQIPEMFADTRETETVFGPVIQAGLEALKAADCAGKLFIFHSSLPIAEAPGKLKNREDK 867

  Fly   762 KLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYF 826
            ||:||||||::..||.:.||||.::||.|||.||||:|.|.|:|:||:|.|...|||.::|||||
Zfish   868 KLVGTDKEKSLFQPQVSFYNTLAKDCVAQGCCVDLFLFPNQYVDVATLGVVPTSTGGSIYKYTYF 932

  Fly   827 QADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISI 891
            ||..|.:|.:.|:.::|.:.:.||||||||||.|||.|:|:|.|:||||||||||.:|..|::::
Zfish   933 QASSDQERFLNDLRRDVQKQMGFDAVMRVRTSTGIRATDFFGSFYMSNTTDVELAGLDCDKTVTV 997

  Fly   892 EIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQAC 956
            |.:|||||:.|....:|.|:||||||||||||:.|:|:...:.:||:::.|:.|.::.||.|.|.
Zfish   998 EFRHDDKLSEETGALMQCAVLYTSCSGQRRLRVHNMAVNCCSQLADLYRNCETDTIINFFVKYAY 1062

  Fly   957 FKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGS 1021
            ..::....|.|:|:|:::.|||||||||:|.||:||||||||||:||||:|.:|:||:|.:..|:
Zfish  1063 RSVLSSPTKNVRDSLVNQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGA 1127

  Fly  1022 DMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILENG 1086
            |::||||:|:.|.:.:||:.:|..:.|||.:|:..:..|.|.||..||.:.|:....|.|:||||
Zfish  1128 DVSLDDRAYLRQLVSAMDVAESHVFFYPRLLPLQKLDAESTSLPLAVRDSEERLSRGGVYLLENG 1192

  Fly  1087 VHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNI-VPETPLAKRIHGILEQIMKERSRYMRITW 1150
            :::|:|:|.....:.:|::||.....||.....:: ..:.|.:||:..|:|.|..:|||||::..
Zfish  1193 LNIFIWVGVNAQQELLQNIFGTPAFSQIDPSMTSLPALDNPFSKRLKEIIESIRAQRSRYMKLMV 1257

  Fly  1151 LRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            ::|.||||.:|:||||||:..:|.||||||||||||||:.|||
Zfish  1258 VKQEDKLELIFKHFLVEDKSNNGGASYVDFLCHMHKEIRQLLS 1300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	420/816 (51%)
		zf-Sec23_Sec24	522..559	CDD:282641	24/36 (67%)
		Sec24-like	599..847	CDD:238756	146/247 (59%)
		Sec23_BS	848..932	CDD:285301	52/83 (63%)
		Sec23_helical	950..1043	CDD:282646	49/92 (53%)
		Gelsolin	1061..1135	CDD:279020	23/74 (31%)
sec24c	XP_005156414.2	Jun	<180..279	CDD:281890	33/124 (27%)
		COG5028	409..1296	CDD:227361	448/895 (50%)
		zf-Sec23_Sec24	628..665	CDD:282641	24/36 (67%)
		Sec24-like	705..949	CDD:238756	145/243 (60%)
		Sec23_BS	954..1037	CDD:285301	52/82 (63%)
		Sec23_helical	1053..1149	CDD:282646	49/95 (52%)
		Gelsolin	1170..1242	CDD:279020	22/71 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581801
Domainoid	1	1.000	319	1.000	Domainoid score	I1220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3615
Inparanoid	1	1.050	888	1.000	Inparanoid score	I374
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001889
OrthoInspector	1	1.000	-	-		otm24657
orthoMCL	1	0.900	-	-		OOG6_101536
Panther	1	1.100	-	-	LDO	PTHR13803
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1423
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900