Protein Alignment Sec24CD and sec24d

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: NP_001171403.2
• Gene: sec24d / 553407
• ZFINID: ZDB-GENE-070117-2501
• Length: 1030
• Species: Danio rerio
• Alignment Length: 1150
• Identity: 496/1150 - (43%)
• Similarity: 688/1150 - (59%)
• Gaps: 132/1150 - (11%)

  Fly    54 QPQYGAPPPTSAASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFN 118
            |..|.|.||.|             |....|||.:.|.|       .|| ||....|...|..|::
Zfish     3 QQGYVATPPYS-------------QAQAGMGGYAAGFG-------NPP-PQSHYGAYGSPTQGYS 46

  Fly   119 QFNSNAAPPPTNNNNAAFGAPPPTQAGSY-----VNGALPPSSTPQSVASGINQMSLNSATLAGL 178
            ...:....||.::.:   |.|||..:..|     .|||.|.|
Zfish    47 APPTGVLKPPASSPS---GMPPPPVSSQYGTNIQQNGAHPHS----------------------- 85

  Fly   179 PHMPPPKAATPGAAP-GQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRP 242
              .|||.:::|..:| ||||..|..|.:|       .||.....:.|:.....|  .||   .||
Zfish    86 --FPPPVSSSPSMSPYGQPPPTAFHSMAQ-------ALPPTQQLTNQMSAMNIA--GYG---QRP 136

  Fly   243 GQPQLPPGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPY 307
            .|   .|..:.|.:.|.. ||....|.|||..||   |||. |...|  ||::..|..|.|
Zfish   137 VQ---SPSNSAPAHFQTS-PPPPVMGHPPLSPPG---QQPS-PLGSP--PPMATMGSMPAP---- 187

  Fly   308 GAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQQPMPGYP 372
                            |.|..|.|.|:..|    ||.  .||        |||.||| .|:.|
Zfish   188 ----------------PMGMSGPPGPVVHQ----PPH--GPQ--------GYPQQPG-SPIAG-- 219

  Fly   373 PQP-GQQLGGPGYP-PQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQVMI 435
              | |.|:.||... ||.|| |||     ||...|...||      |..::||||.:|:..|::.
Zfish   220 --PYGAQMAGPQMAGPQTGA-FPG-----GFAGGPAQMAG------PPQKKLDPDSIPSTTQMIA 270

  Fly   436 ENQRLSGGP-FVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNI 499
            ::|...||. :|||..|.:||||||.|.|.||||:||||:|.:.|..|.|.||.|...:||...|
Zfish   271 DDQAKRGGQVYVTNIRGQVPPLVTTNFTVQDQGNASPRFMRCTTYSFPCTADLAKQCKVPLAAII 335

  Fly   500 SPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHL 564
            .|.|.|.:.|....:||.||.||||||||||||.|.|||:|.||||||..|...:||..:|:|||
Zfish   336 KPFATVPKNETPLYVVNHGETGPIRCNRCKAYMCPYMQFIDGGRRFQCSFCSCVNEVPVHYFQHL 400

  Fly   565 DHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKN 629
            ||.|:|:|.:|||||.||:|||.||.|||:||.||..||:||:||||||.:|||||.|:|.::|.
Zfish   401 DHMGRRMDLYERPELSLGSYEFAATLDYCKNNKPPNPPAYIFMIDVSYNNIKSGLVRLICEELKT 465

  Fly   630 ILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEES 694
            :|..||.::|.:.|.::|||:|||..:||||:||:|||||||||.|..|||:|||||||.:.:||
Zfish   466 LLDRLPKEEGAESSSIKVGFVTYNKILHFYNVKSALAQPQMMVVSDTAEMFVPLLDGFLVNFQES 530

  Fly   695 AAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRD 759
            .|||:.|:::||.|||||.|:||:..|.:|||||||||:..:|||.:|:|::|.|||||||||||
Zfish   531 RAVINNLLDQIPDMFADTNESETVFAPVVQAGLEALKAAECSGKLFIFHSSIPTAEAPGKLKNRD 595

  Fly   760 DRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYT 824
            |:||:||:||||:..||...|..|.::||.|||.||||:|.|.|:|:||:|.|...|||.::||:
Zfish   596 DKKLVGTEKEKTLFQPQRGVYEQLTKDCVAQGCCVDLFLFPNQYVDIATMGDVPSHTGGSIYKYS 660

  Fly   825 YFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSI 889
            .||.:|:|::.:.|:.::|.:.|.|||:|||||..|.|.|:|:|..:|:||||||:|::|..|::
Zfish   661 NFQVEVNGQQFLSDLSRDVEKSIGFDAIMRVRTGTGFRATDFFGAVYMNNTTDVEMAAVDCDKAV 725

  Fly   890 SIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQ 954
            ::|.||||.|:.|....:|.|||||:..|||||||.||:|..::.:::::|.|:.||::.||||.
Zfish   726 TVEFKHDDTLSEESGAVMQCALLYTTIGGQRRLRIHNLSLNCSSQLSELYKSCETDALINFFAKS 790

  Fly   955 ACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISG 1019
            |...::....|.|::.|::::|.:||||||:|.||::..|||||:.:|:.|:|.:.|||..|:..
Zfish   791 AYRAMLNQPMKTVREILVNQTAHMLACYRKNCASPSAVSQLILPDAMKVFPVYMNSLLKTPALVS 855

  Fly  1020 GSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILE 1084
            .::::.|||::....:.:|.:.::...||||.||:|.:......||..|||:.|:..|.|.::||
Zfish   856 STELSTDDRAFHRFMVNAMGVEETQVLLYPRLIPLHTMDVSSESLPAAVRCSEERLNESGMFLLE 920

  Fly  1085 NGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNI-VPETPLAKRIHGILEQIMKERSRYMRI 1148
            ||:.:|:|||||.|||.:|::|.|.....:..|..:: |.:.|.::::|.|:.:|.::|:..|::
Zfish   921 NGLSMFLWLGQACSPDLIQNLFNVPSFGHLPAEGTSLPVLDNPHSRKLHSIISRISQQRAASMKL 985

  Fly  1149 TWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            ..::|.|:.|..||..||||:|..|.|||:||||.:|:||:.||:
Zfish   986 LIVKQKDRAEMSFRQLLVEDKGLHGGASYMDFLCFVHREIRQLLT 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	54/207 (26%)
		COG5028	395..1190	CDD:227361	391/796 (49%)
sec24d	NP_001171403.2	Med15	<2..>264	CDD:312941	113/382 (30%)
		COG5028	163..1026	CDD:227361	432/919 (47%)