Protein Alignment Sec24CD and sec24b

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: XP_001921634.4
• Gene: sec24b / 334633
• ZFINID: ZDB-GENE-030131-6565
• Length: 1184
• Species: Danio rerio
• Alignment Length: 1250
• Identity: 360/1250 - (28%)
• Similarity: 573/1250 - (45%)
• Gaps: 191/1250 - (15%)

  Fly    57 YGAPPPTSAASQPYLNGNYQQQLATSMGGLSV---GGGVGGANP-LKPPLPQGAPAAAAPPPTGF 117
            ||.|       |..:| ||....|.:.||.:.   ..|.|.|.| :.||    :...::.||.|:
Zfish     6 YGNP-------QSAVN-NYSMSSAQNGGGAATVPCQNGPGQAYPAMYPP----SSYYSSAPPAGY 58

  Fly   118 NQFNSNAAPP----PTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGL 178
            .....::|||    |.:..:         .:|:|...:..||..|.:..|   |.:.:..:.:..
Zfish    59 PTMTGHSAPPAGKIPVSGTD---------YSGNYYQNSSGPSLYPAAPGS---QTAAHPYSTSNA 111

  Fly   179 PHMPPPKAATPGAAP----GQP-PIPAAGSTSQPPLPGQPPLP--------GQPPFSGQIPTSQP 230
            | :|..:.|.|.|.|    ||| ..|:.|.|...|...||.|.        |.|.:......|.|
Zfish   112 P-VPSLQQAAPYAMPAGYYGQPYSQPSHGQTHAQPQQMQPSLVPASSSNNLGAPLYPIVSYPSAP 175

  Fly   231 APSPYG-VPSSRPGQPQLPPGAT--PPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLP 292
            ..|.|| :.||:.|..| ||.:|  ||..||..| .|..||......|.    .||:     |.|
Zfish   176 GSSQYGTLRSSQTGIGQ-PPVSTVMPPPPTQSSL-QQYSQGKGATPTPA----HPGY-----GAP 229

  Fly   293 PLSQPGLPPQPGAPYGAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQF--GAPQPGYPGQ 355
            ||||   .|.......|.|| .|...........:.||||...|......|..  ||.....||.
Zfish   230 PLSQ---TPTVNGQSNAVQQ-HYDQNLVNPMGHHYSGAPPTSTGPNTERTPSGTPGASVHSSPGH 290

  Fly   356 QPG-------------------------YPPQPGQQPMPG----------YPPQPG--QQLGGPG 383
            ..|                         :..:..:....|          ..|.|.  :.|.|.|
Zfish   291 HQGLLYADRGVNNAVSSAAGDHSSSSSDHEEEDEEDEEAGGDSSSTTTGSASPVPNSYESLEGGG 355

  Fly   384 YP--PQPGAGFPGQPGRP-GFNQPPM-PGAGNMYQQAPQARRLDPDQMP-----NPIQVMIENQ- 438
            |.  ..|.||.|.:...| |:|.|.| ||    |||:|..|   ||..|     ||......:|
Zfish   356 YQDLAAPPAGVPNKQAPPFGYNYPTMHPG----YQQSPAPR---PDSSPAHGGYNPSGYQPYSQP 413

  Fly   439 ------------RLSGGP---FVTNQP-------GLLPPLVTT---KFVVHD--QGNSSPRFLRS 476
                        .|||.|   ..|.:|       .:|||...:   ..:..|  :.|.||...|.
Zfish   414 FPSLNELSSALGGLSGVPELEMETLRPLNLLQERNILPPKQASPPEPNLSSDLRKVNCSPDTFRC 478

  Fly   477 SLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDA 541
            :|..||.|..||....|||.|.:.|...:    .:.|::....:  :||..|:.|::|.:.|:|.
Zfish   479 TLTNIPQTQALLNKARLPLGLLLHPFRDL----TQLPVITSNTI--VRCRSCRTYINPFVSFLDQ 537

  Fly   542 GRRFQCLMCKVTSEVHQNY-YQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFI 605
             ||::|.:|...::|...: |..:  |....:.|:|||:...|.||:|:.||...  ||:...::
Zfish   538 -RRWKCNLCYRVNDVPDEFMYNPV--TRSYGEPHKRPEVQNSTVEFIASSDYMLR--PPQPAVYL 597

  Fly   606 FIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQM 670
            |::|||:|.|:||.:::.|..:.:.|..||.|     ::.|:||:|::||:||||::..|:||||
Zfish   598 FVLDVSHNAVESGYLNVFCQSLLDNLDKLPGD-----TRTRIGFVTFDSTIHFYNLQEGLSQPQM 657

  Fly   671 MVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNA 735
            :||.|::::|:|..|..|.:.:||..::..|:..:|.||:.|:||::.|.||:||..:.:  ...
Zfish   658 LVVSDIEDVFIPTHDSLLVNLKESKELVKDLLNALPGMFSQTRETQSALGPALQAAYKLM--CPT 720

  Fly   736 AGKLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFN 800
            .|::.||.:.||...| |.|::|:|..|..:.|....|.|.|..|..|..:|..|...||||:.:
Zfish   721 GGRVSVFQTQLPTLGA-GLLQSREDPNLRSSTKTVQHLAPATDFYKKLALDCSGQQIGVDLFLLS 784

  Fly   801 NAYIDLATIGQVSRLTGGEVFKYTYF---QADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIR 862
            :.|.|||::..||:.:.|.||.|..|   ......::|.:|:.:.:||.|.|:||||:|.:.|:.
Zfish   785 SQYSDLASLACVSKYSAGSVFYYPSFHHIHNTAQRQKLQRDLQRYLSRKIGFEAVMRIRCTKGLS 849

  Fly   863 PTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNL 927
            ...|:|:||:.:|..:.||:::.....::::..::.||.......|.||||||..|:||:|:..|
Zfish   850 IHTFHGNFFVRSTDLLSLANVNPDSGFAVQMSIEESLADTSLACFQAALLYTSSKGKRRIRVHTL 914

  Fly   928 ALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSA 992
            .|.|.:.:::||...|:.|:....|..|..:.:..|....:|.|::.....|:.||.:.::...:
Zfish   915 CLPVVSQLSEVFAGADIQAITCLLANMAIDRSVSSSLSDARDALVNAVVDCLSAYRANGSNIQPS 979

  Fly   993 GQLILPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHN- 1056
            | ||.|..|:|.|||...|||..|:..|:...||:|.:.:....|..|:|.:..::|....|.|
Zfish   980 G-LIAPAALRLFPLYVLALLKQKALRTGTSTRLDERVFSMCEFKSQPLHQIMRMVHPDLYRIDNM 1043

  Fly  1057 -----------VVPEETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQG 1110
                       |||:    |..::.|.||...:||::::.|..:::|:|:..:..|::.|.|...
Zfish  1044 TEQGALHLNDSVVPQ----PPLLQLTAEKLTREGAFLMDCGSVMYLWVGKCCNEMFIRDVMGFPN 1104

  Fly  1111 LQQIALERFNIVPE--TPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDG 1173
            ...:. .....:||  |..::|....:..:::.|:.:.....::.:...:|.|...||||| |:.
Zfish  1105 YASLP-SSMTEIPELQTTYSERTRAFISWLLESRTFHPAFHVVKDDAPAKSSFFQHLVEDR-TES 1167

  Fly  1174 SASYVDFLCHMHKEI 1188
            :.||.:||.|:.:::
Zfish  1168 AFSYYEFLLHVQQQM 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	63/221 (29%)
		COG5028	395..1190	CDD:227361	256/846 (30%)
sec24b	XP_001921634.4	None