Protein Alignment Sec24CD and Sec24d

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: NP_001296382.1
• Gene: Sec24d / 310843
• RGDID: 1311720
• Length: 1034
• Species: Rattus norvegicus
• Alignment Length: 1109
• Identity: 484/1109 - (43%)
• Similarity: 670/1109 - (60%)
• Gaps: 99/1109 - (8%)

  Fly   100 PPLPQGAPA-AAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVAS 163
            ||..|..|. ..:||..|.....|:.:.||      ....||.....:..:|.|||...|    .
  Rat    10 PPYSQSQPGMGISPPHYGHYGDPSHVSSPP------GMMKPPGPTGATAPSGLLPPGPLP----P 64

  Fly   164 GINQMSLNSATLAGLPHMPPPKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTS 228
            |..|...|.|..||.|         |...||.||:    :.:.||.....||| |..:.|  |.|
  Rat    65 GPPQFGPNGAHAAGHP---------PQRFPGHPPV----NNAAPPYASGQPLP-QSSYPG--PGS 113

  Fly   229 QPAPSPYGVPSSRPGQPQL---PPGATPPTYTQPGLPPQQQ---QGIPPLQQPGIPQQQPGFPPQ 287
            ..:.:..|   |:.|..|:   ..|.||.....||  ||..   ||.|...||.|  .|||  ||
  Rat   114 TSSVTQLG---SQFGSMQINNYGVGVTPQGQGPPG--PQSAGAFQGPPQPTQPSI--LQPG--PQ 169

  Fly   288 QPGLPPLSQPGLPPQPGA-PYGAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPG 351
            .|..||.:..|    ||| |..||..  ...|.|...|......|||.|||...|         |
  Rat   170 VPPPPPTAMNG----PGASPMSAPAH--RQDGLPAPTPLNAQYQPPPPPGQTLGA---------G 219

  Fly   352 Y-PGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQ 415
            | |.|...|.||.|           |.||..||       ||||.|.:             |...
  Rat   220 YHPQQAANYGPQMG-----------GAQLSYPG-------GFPGGPAQ-------------MAGP 253

  Fly   416 APQ-ARRLDPDQMPNPIQVMIENQRLS--GGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSS 477
            ||| .|:||||.:|:|||| |||.|.:  |..:.||..|.:||||||:.::.|||:||||::|.:
  Rat   254 APQLQRKLDPDSIPSPIQV-IENDRATRGGQVYTTNTRGQVPPLVTTECMIQDQGHSSPRYIRCT 317

  Fly   478 LYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAG 542
            .||.|.|.|:.|...:||...|.|.|.:...|....:||.||.||:|||||||||.|.|||::.|
  Rat   318 TYCFPCTSDMAKQAQIPLAAVIKPFADIPSNETPLYLVNHGESGPVRCNRCKAYMCPFMQFIEGG 382

  Fly   543 RRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFI 607
            ||:||..|...::|...|:|||||.|:|:|.:|:|||.||:||::||.||||.|.||..|||||:
  Rat   383 RRYQCGFCSCVNDVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVATLDYCRKNKPPNPPAFIFM 447

  Fly   608 IDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMV 672
            |||||:.:|:|||.|:|.::|.:||.||.::.::||.:||||||||..:||:|:||:||||||||
  Rat   448 IDVSYSNIKNGLVKLICEELKTVLKRLPKEEHEEKSAIRVGFITYNKVLHFFNVKSNLAQPQMMV 512

  Fly   673 VGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAG 737
            |.||.|:|:|||||||.:.|||.:||..|:::||.||||:.|.||:..|.||||:|||||:...|
  Rat   513 VTDVGEVFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPG 577

  Fly   738 KLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNA 802
            ||.:|:|:||.||||||||||||:||:.|||||.:..|||..|.:|.::||...|||.||:|.:.
  Rat   578 KLFIFHSSLPTAEAPGKLKNRDDKKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQ 642

  Fly   803 YIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFY 867
            ::|:|::|.|..||||.::||..||..||.:|.:.|:..::.:.|.|||:||||||.|.|.|:|:
  Rat   643 FVDVASLGLVPLLTGGSLYKYNVFQVHVDSQRFLNDLRNDIEKKIGFDAIMRVRTSTGFRATDFF 707

  Fly   868 GHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVT 932
            |..||:||||||:|:||..|::::|.||||||:.:....:|.|||||:..|||||||.|:||..:
  Rat   708 GGIFMNNTTDVEMAAIDCDKAVTVEFKHDDKLSEDVGALIQCALLYTTIGGQRRLRIHNVALNCS 772

  Fly   933 TTIADVFKCCDLDAMMLFFAKQACFKLMEHSP-KQVKDNLIHRSAQILACYRKHCTSPTSAGQLI 996
            |.:||::|.|:.||::.||||.| ||.:.:.| |.:::.|::::|.:||||||||.||::|.|||
  Rat   773 TQLADLYKSCETDALINFFAKSA-FKAVLNQPLKTIREILVNQTAHMLACYRKHCASPSAASQLI 836

  Fly   997 LPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEE 1061
            ||:.:|:||:|.:.||||..:....:::.|:|:|..|.:::|.:..|..:.||..:|||.:..:.
  Rat   837 LPDSMKVLPVYMNSLLKNCVLLSRPEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTLDVKS 901

  Fly  1062 TDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPE-- 1124
            ..||..|||:..:..|:|.::|.:|:::|:|.|.....:.:|.:|.|.....|..:..:: ||
  Rat   902 AALPPAVRCSESRLSEEGIFLLADGLNMFLWFGVGSPAELIQGIFNVPSFAHINTDMTSL-PEVG 965

  Fly  1125 TPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIK 1189
            :|.::::..|:..|.:::...|::..::|.::.|.|||.|||||:|..|.:|||||||.:||||.
  Rat   966 SPHSQQLRMIMNNIQQKKPYSMKLIIVKQREQREMVFRQFLVEDKGLYGGSSYVDFLCCVHKEIC 1030

  Fly  1190 DLLS 1193
            .||:
  Rat  1031 QLLN 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	64/208 (31%)
		COG5028	395..1190	CDD:227361	385/800 (48%)
Sec24d	NP_001296382.1	PRK07764	<70..258	CDD:236090	83/258 (32%)
		COG5028	217..1029	CDD:227361	401/854 (47%)