DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and SPBC4.03c

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_595476.1	Gene:	SPBC4.03c / 2540710	PomBaseID:	SPBC4.03c	Length:	891	Species:	Schizosaccharomyces pombe

Alignment Length:	906	Identity:	276/906 - (30%)
Similarity:	447/906 - (49%)	Gaps:	92/906 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 YPGQQPGY-PPQPGQQPM---------PGYPPQPGQQLGGPGYPPQPGAGFPGQPGR-------- 398
            ||||...| .|:..:|.:         |....|...|:....| .|.|:....||.|
pombe     3 YPGQFGNYGNPETYRQNVAGNIASYGGPEIDTQLAAQMNAQMY-IQQGSAMAPQPRRARRHKDAH 66

  Fly   399 ----------------------PGFNQPPMPGAGNMYQQ--APQARRLDPDQMPNPIQVMIENQR 439
                                  |..|. |.|...::..:  :.....|||..:|:..:|..|:|:
pombe    67 AYDMSLTDAEPALAPVMSPAIPPSMNY-PTPSTPSVLPESFSNDTNLLDPAALPSAPEVRYEDQQ 130

  Fly   440 L-SGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLA 503
            | ....|.|.:.| .||:.||.||.::|||||.:|::.:.|.||.|.|:...:.:||.:.:.|.|
pombe   131 LFKNQIFNTMEKG-SPPMSTTDFVGYEQGNSSSKFVQFTSYAIPATNDVCNASGIPLGMIVQPFA 194

  Fly   504 KVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTG 568
            ::...|...|:|:.....|.||.:|:.|::|.:||..|..::.|.:|...:..:.:.:..|  .|
pombe   195 ELRPDEAPVPVVDNTNSNPPRCKKCRGYINPFIQFTMASSKWTCNLCGSENSFNDDGFNPL--VG 257

  Fly   569 QRVDKHE-RPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNIL- 631
            .:.|..| ||||.:||.:|...|||.....||:...|:|:|||||.....||..:....|:|||
pombe   258 SQHDGVESRPELNVGTIDFKVGKDYWIKEDPPKPARFVFMIDVSYEASSKGLPKVAAEAIRNILY 322

  Fly   632 KHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAA 696
            ..:|:|     ..|::..:.::.:|:|:|:..:|.||.|:...|::..|:|...|....|..|..
pombe   323 GPVPLD-----PNVKIAIVCFDRSVNFFNLSPNLEQPHMLAASDLENPFVPFSSGLFVDPIASKV 382

  Fly   697 VIDALMEEIPRMFADTKETETILYPAIQAGLEALK--ASNAAGKLLVFNSTLPIAEAPGKLKNRD 759
            ||:.|::..|.:|.|.|..|    |.:...||.:|  .....||..||.|.|| ....|||::|:
pombe   383 VIERLLDSFPAIFQDVKIPE----PVVGNALEVVKLLLKETGGKAFVFVSALP-TMGLGKLRHRE 442

  Fly   760 DRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYT 824
            |::|.||..||.:...|...|.:|..|.|..|..||:|....||:|:||:|.|:.|:||:::.|:
pombe   443 DQRLYGTSDEKNLWNTQDKWYTSLADEYVTAGIGVDIFFTATAYVDVATVGSVATLSGGQIYHYS 507

  Fly   825 YFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSI 889
            .|.||.||.||.||:.::|:|...:..:::.|.|.|:|.:::.|:|......|:|..|:||.||:
pombe   508 NFVADRDGSRLKQDLFRSVTREQGYRVMLKTRCSNGLRVSKYLGNFLQRTPQDIEFGSLDADKSV 572

  Fly   890 SIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQ 954
            ::...:|.||....:.:.|.|:|||:.||:||:|::|....||:...|......::.::...||.
pombe   573 TVLFSYDGKLNGALDAHFQTAVLYTTPSGERRVRVVNYCCAVTSKSYDTISLAIVEPIVAVLAKI 637

  Fly   955 ACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISG 1019
            |...:...|.|.....|:....:||:.|||...:..:.|||:||:.|.|||:....:||:.||..
pombe   638 ASTNIAAGSLKDTSVRLVEGVVKILSSYRKVAANRLTPGQLVLPKNLVLLPILILAVLKSSAIRS 702

  Fly  1020 GSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETD-LPTP-------------VRC 1070
            || :..|.|...::.:.:..:.:.:..|||....:|.:.|  || ||.|             ||.
pombe   703 GS-IHSDIRVSQLREVRAAPIQELMLNLYPNIYALHQLQP--TDCLPDPENTGCLPINMPLCVRA 764

  Fly  1071 THEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQI----ALERFNIVP--ETPLAK 1129
            :.:..::.||:::..|...::|..|..||..:|.:.||:.|:.|    |||    :|  :|.|:.
pombe   765 SRKFIEDGGAFLIVTGQKSYLWFHQRTSPLLLQDLLGVESLEDIDSLKALE----LPTLDTVLSV 825

  Fly  1130 RIHGILEQI-MKERSRYMRITWLRQN-DKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEI 1188
            ::..:|..: |:..|..:....:||. |..|......||||...:| ..|:|||..:|:.:
pombe   826 QVRNLLSSLRMQFPSMALHPQIVRQGLDGSEGEIFSTLVEDNTREG-FGYLDFLTKIHESL 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	263/853 (31%)
		zf-Sec23_Sec24	522..559	CDD:282641	11/36 (31%)
		Sec24-like	599..847	CDD:238756	90/250 (36%)
		Sec23_BS	848..932	CDD:285301	27/83 (33%)
		Sec23_helical	950..1043	CDD:282646	28/92 (30%)
		Gelsolin	1061..1135	CDD:279020	25/93 (27%)
SPBC4.03c	NP_595476.1	COG5028	1..887	CDD:227361	276/906 (30%)
		zf-Sec23_Sec24	213..250	CDD:282641	11/36 (31%)
		Sec24-like	289..530	CDD:238756	90/250 (36%)
		Sec23_BS	531..615	CDD:285301	27/83 (33%)
		Sec23_helical	630..725	CDD:282646	28/95 (29%)
		Gelsolin	756..831	CDD:279020	20/78 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	159	1.000	Domainoid score	I1003
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3615
Inparanoid	1	1.050	402	1.000	Inparanoid score	I378
OMA	1	1.010	-	-		QHG53542
OrthoFinder	1	1.000	-	-		FOG0001889
OrthoInspector	1	1.000	-	-		oto100861
orthoMCL	1	0.900	-	-		OOG6_101536
Panther	1	1.100	-	-	LDO	PTHR13803
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1962
SonicParanoid	1	1.000	-	-		X1423
TreeFam	1	0.960	-	-
	14	13.860