DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and Sec24c

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	XP_006518876.1	Gene:	Sec24c / 218811	MGIID:	1919746	Length:	1121	Species:	Mus musculus

Alignment Length:	1238	Identity:	557/1238 - (44%)
Similarity:	738/1238 - (59%)	Gaps:	162/1238 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNPNMYGPP-PTQFQQQPQF-GAPPPNSGGWP-PQQQQLPQ-----QQPPQQQLPPQQQQQQPQY 57
            ||.|...|| |...|.||.: |....:.||.| |.....|.     ..|..||.|||...:.|..
Mouse     1 MNVNQSAPPVPPYGQNQPIYPGYHQSSYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPS 65

  Fly    58 GAPPPTSAASQPYLNGNYQQQLATSMGGLSVGGG-------VGGANPLKPPLPQGAPAAAAP--- 112
            ...||.|||..|.....|.|   ...|.:..|..       |.|:....|||   ||..:.|
Mouse    66 SGAPPASAAQVPCGQTTYGQ---FGQGDIQNGPSSTAQMQRVPGSQQFGPPL---APVVSQPAVL 124

  Fly   113 PPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAG 177
            .|.|         ||||:....|      ..||..::||:..:..|                 :|
Mouse   125 QPYG---------PPPTSTQVTA------QLAGMQISGAVAQAPPP-----------------SG 157

  Fly   178 LPHMPPPK-AATPGAAPGQPPIPAAGSTSQPPL------PG-QPPLPGQPPFSGQIPTSQPAPSP 234
            |.:.||.. |:..|..|...|..:...:..|||      || ||||...||.:          |.
Mouse   158 LGYGPPTSLASASGNFPNSGPYGSYPQSQAPPLSQAQGHPGVQPPLRSAPPLA----------SS 212

  Fly   235 YGVPSSRPGQPQLPPGATPPTYTQPG-LPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQ-- 296
            :..|:|  |.||:|        :..| |||.|..|..|:.|.......|.     |.|||.:|
Mouse   213 FTSPAS--GGPQMP--------SMTGLLPPGQGFGSLPVNQANHVSSPPA-----PALPPGTQMT 262

  Fly   297 -PGLPPQPGAPYGAPQQGGY----SGGF-PGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYP-- 353
             |.:||.|  |..:|||.||    :|.| |.:.|                 .|.:.:|.||.|
Mouse   263 GPPVPPPP--PMHSPQQPGYQLQQNGSFGPARGP-----------------QPNYESPYPGAPTF 308

  Fly   354 GQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQ-PPMPGAGNMYQQAP 417
            |.||| ||||       .||   ::|.....|            .|..|: ||         |..
Mouse   309 GSQPG-PPQP-------LPP---KRLDPDAIP------------SPQLNELPP---------QQK 341

  Fly   418 QARRLDPDQMPNPIQVMIENQRLSGG--PFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYC 480
            ...|:|||.:|:|||| ||:.|.:.|  ||||...|.:||||||.|:|.||||:|||::|.:.|.
Mouse   342 TRHRIDPDAIPSPIQV-IEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYN 405

  Fly   481 IPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRF 545
            ||.|.|:.|...:||...|.|||::...|..|.:|:.||.||:|||||||||.|.|.|::.||||
Mouse   406 IPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRF 470

  Fly   546 QCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDV 610
            ||..|...::|...|:|||||||:|||.::||||.||:||||||.|||:||..|..|||||:|||
Mouse   471 QCSFCSCVNDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDV 535

  Fly   611 SYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGD 675
            |||.:::|||.|||.::|::|.:||.:.|.::|.:||||:|||..:||||:||||||||||||.|
Mouse   536 SYNAIRTGLVRLLCEELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSD 600

  Fly   676 VQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLL 740
            |.:||:|||||||.:..||.|||.:|:::||.|||||:||||:..|.||||:|||||:..||||.
Mouse   601 VADMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLF 665

  Fly   741 VFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYID 805
            :|:::||||||||||||||||||:.||||||:..|||..|.||.:|||.|||.||||:|.|.|:|
Mouse   666 LFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVD 730

  Fly   806 LATIGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHF 870
            :||:..|.:||||.|:||..||.:.|.:|.:.|:.::|.:.:.||||||||||.|||..:|:|.|
Mouse   731 VATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAF 795

  Fly   871 FMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTI 935
            :||||||||||.:|..|::::|.||||:|..|....||.|||||||:|||||||.||||...|.:
Mouse   796 YMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQL 860

  Fly   936 ADVFKCCDLDAMMLFFAKQACFKLMEHSP-KQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPE 999
            ||:::.|:.|.::.:.||.| ::.:.:|| |.|:|.||.:.|||||||||:|.||:|||||||||
Mouse   861 ADLYRNCETDTLINYMAKFA-YRAVLNSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPE 924

  Fly  1000 CLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIP-IHNVVP-EET 1062
            |:||||:|.:|:||:|.:..|:::|.|||:||.|.:.|||:.::..:.|||.:| :....| :.|
Mouse   925 CMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLVRTKSPLDST 989

  Fly  1063 DLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVP--ET 1125
            ..|..||.:.|:......|:||||::||||:|.::....|||:|.|....||. ...:::|  :.
Mouse   990 AEPPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQIT-SGLSVLPVLDN 1053

  Fly  1126 PLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKD 1190
            ||:|::.|:::.:..:|.|||::..::|.||||.:|:||||||:...|.||||||||||||||:.
Mouse  1054 PLSKKVRGLIDSLRAQRMRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQ 1118

  Fly  1191 LLS 1193
            |||
Mouse  1119 LLS 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	431/802 (54%)
		zf-Sec23_Sec24	522..559	CDD:282641	21/36 (58%)
		Sec24-like	599..847	CDD:238756	150/247 (61%)
		Sec23_BS	848..932	CDD:285301	55/83 (66%)
		Sec23_helical	950..1043	CDD:282646	52/93 (56%)
		Gelsolin	1061..1135	CDD:279020	27/75 (36%)
Sec24c	XP_006518876.1	Retinal	<12..235	CDD:406015	76/280 (27%)
Sec24c	XP_006518876.1	COG5028	181..1117	CDD:227361	493/1014 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1222
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3615
Inparanoid	1	1.050	950	1.000	Inparanoid score	I342
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001889
OrthoInspector	1	1.000	-	-		otm42900
orthoMCL	1	0.900	-	-		OOG6_101536
Panther	1	1.100	-	-	LDO	PTHR13803
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1962
SonicParanoid	1	1.000	-	-		X1423
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860