DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and sec-24.2

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_502354.2	Gene:	sec-24.2 / 178183	WormBaseID:	WBGene00004756	Length:	984	Species:	Caenorhabditis elegans

Alignment Length:	1191	Identity:	307/1191 - (25%)
Similarity:	501/1191 - (42%)	Gaps:	243/1191 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PNSGGWPPQ--QQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSAASQPYLNGNYQQQLATSMGGL 86
            |.:.|:|..  |.|..|.|..||.....|....|...|||..:|...|:......|:
Worm     8 PGNVGFPQAYGQNQNQQYQHVQQFSQFSQPSAAPLNNAPPNYAANPFPFPTATTSQE-------- 64

  Fly    87 SVGGGVGGANPLKP--PLPQGAPAAAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVN 149
                      |:||  .:|.|||:         .|:| :|||    |...|..|.|...||.
Worm    65 ----------PVKPVSQIPNGAPS---------YQYN-HAAP----NYPTAASAFPAHSAGF--- 102

  Fly   150 GALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPKAAT-PGAAPGQPP-IPAAGSTSQPPLPGQ 212
            ...|||.:|.:      |.|:|.      .|.|||.|.: |.|.|..|| :.:|..:.|||:|
Worm   103 SHQPPSFSPAT------QPSMNG------HHAPPPPAVSRPPAFPTPPPSVGSAAPSIQPPIP-- 153

  Fly   213 PPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGATP-PTYTQPGLP-PQQQQGIPPLQQP 275
                      ..:.:::|||.|...|         ||..|| |:|.|...| ||.....||
Worm   154 ----------SALASARPAPFPAAQP---------PPAPTPTPSYQQQMAPRPQAPAAYPP---- 195

  Fly   276 GIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAA 340
              ..||.|:|||             ||..:.||.||
Worm   196 --ASQQQGYPPQ-------------PQQNSQYGQPQ----------------------------- 216

  Fly   341 APPQFGAPQPGYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQP- 404
                  .|||    |......|.||..|.| .|.|.||:|                   |:...
Worm   217 ------VPQP----QMQNMNQQFGQMNMSG-APGPQQQMG-------------------GYRNDI 251

  Fly   405 -PMPGAGNMYQQAPQARRLD-PDQMPNPIQVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQG 467
             .:....|:.|...:...:. |.|:.||                                   ..
Worm   252 IDLIAERNVQQLGFEDIEIQIPQQVANP-----------------------------------NA 281

  Fly   468 NSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYM 532
            :..|...||:|..:|.|.:|||.:.||..:.:.|...|    ....|:....:  :||..|:.|:
Worm   282 HVDPNIFRSTLAQVPQTEELLKKSRLPFAITLHPFRDV----KNLNIIQTSNI--VRCRYCRTYI 340

  Fly   533 SPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNT 597
            :|.:...| .|.::|.:|...:::..::... ..|....|...|||:...|.||:|..:|...
Worm   341 NPYVYLPD-HRHWKCNLCNRNNDLPDDFCWD-PVTKAFGDPRNRPEIQNATVEFIAPSEYMLR-- 401

  Fly   598 PPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIK 662
            ||:...::|:||:|...::||.:|....|:...:..:|   |.|:|  :|.||..:..:||::..
Worm   402 PPQPAVYVFVIDISAAAIQSGYLHTFAEQLLINIDQMP---GDDRS--QVCFIAVDQCLHFFSFS 461

  Fly   663 SSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETE--TILYPAIQA 725
            |:...|..|:|.|:.:.|:|.:...|...::....|...::::|..::....|.  ..|..|::.
Worm   462 SNKRYPNEMIVDDIDDAFLPSVTSLLVPMKKFKDTIRTFIKQLPEFYSQIGPTSNGNCLGSALKL 526

  Fly   726 GLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQ 790
            ....::  ...|::.:|..:||.. ..|.||:|::....|.:     |.|.|..|..|..||...
Worm   527 AQSMIQ--EVGGRISIFQVSLPNL-GLGALKSREESTEGGQN-----LGPATDFYKALSLECTGS 583

  Fly   791 GCSVDLFVFNNAYIDLATIGQVSRLTGGEVF---KYTYFQADVDGKRLIQDIIKNVSRPIAFDAV 852
            ...:|||:||..|.||||:.::::.:.|.|:   .|.|.......||..:.:.:.::|.:.|:||
Worm   584 QICLDLFMFNTQYADLATLSEIAKFSTGCVYHFPNYNYRNDIHQVKRFERTLTRYLTRKLGFEAV 648

  Fly   853 MRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCS 917
            :|:|||.|:..|.|||:||:.:...:.||:::...:::.::..::||  .:.|..|.||||||..
Worm   649 LRIRTSRGLALTGFYGNFFVRSPDLLALANVNPDSALAAQVTLEEKL--PQYVCFQSALLYTSSK 711

  Fly   918 GQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSP-KQVKDNLIHRSAQILAC 981
            |.||:|:..:.|..|..:..::...||.|.:.:.||....:.|..|. ...::.|::.....:..
Worm   712 GDRRIRVHTMCLPTTGDLLQLYNNFDLKATVSYLAKIGVERSMTGSSLADSREALVNAVVDSVGA 776

  Fly   982 YRKHCTSPTSAGQ-LILPEC--LKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQS 1043
            |:|    ..|.|. :::|..  |:|.|.|...:||:.|.|....:.||:|:..:..:....|:|.
Worm   777 YQK----AVSRGSGMLVPRVGHLRLFPSYVLAMLKHPAFSSSRGIRLDERAGAMLMMRFSPLDQI 837

  Fly  1044 VSYLYPRFIPIHNV--VPEETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVF 1106
            :|.:|||...::.:  :||:.. |..:..:.|.....|.|::..|...||::..:..|.|:.:||
Worm   838 LSDIYPRLYRLNELASMPEDQS-PPALPLSFEHISRGGVYLMITGTIAFVYVASSADPGFLVNVF 901

  Fly  1107 GVQGLQQI----ALERFNIVPETPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVE 1167
            |......|    .|||.|     .|::|:|...:|:.:.|.....|..::::..|..||...||:
Worm   902 GTSTYNDIDEYSLLERDN-----ELSRRVHAFFKQVTQFRFYLGPIITIKEHSPLRDVFVRRLVD 961

  Fly  1168 DRGTDGSASYVDFLCHMHKEI 1188
            || ::.:.|||:||.|:.:||
Worm   962 DR-SESTHSYVEFLQHLKREI 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	207/812 (25%)
		zf-Sec23_Sec24	522..559	CDD:282641	9/36 (25%)
		Sec24-like	599..847	CDD:238756	64/252 (25%)
		Sec23_BS	848..932	CDD:285301	31/83 (37%)
		Sec23_helical	950..1043	CDD:282646	22/96 (23%)
		Gelsolin	1061..1135	CDD:279020	20/77 (26%)
sec-24.2	NP_502354.2	zf-Sec23_Sec24	330..366	CDD:282641	9/38 (24%)
		Sec24-like	403..643	CDD:238756	64/252 (25%)
		Sec23_BS	644..726	CDD:285301	31/83 (37%)
		Sec23_helical	742..836	CDD:282646	22/97 (23%)
		ADF_gelsolin	860..>911	CDD:301701	13/50 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820