Protein Alignment Sec24CD and sec-24.1

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: NP_502178.1
• Gene: sec-24.1 / 178078
• WormBaseID: WBGene00004755
• Length: 1126
• Species: Caenorhabditis elegans
• Alignment Length: 1230
• Identity: 510/1230 - (41%)
• Similarity: 687/1230 - (55%)
• Gaps: 149/1230 - (12%)

  Fly     2 NPNMYGPPPTQFQQQPQF---GAPPPNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPT 63
            |..|.|.|..||.|||||   |.|||.:   |.:..|:|...||    |.||...|.|.|.
 Worm     8 NGQMPGYPQQQFNQQPQFQSNGFPPPAA---PQKPAQVPGGFPP----PHQQPNGQYQNGG---- 61

  Fly    64 SAASQPYLNGNYQQQLATSMGGLSVGG-GVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAAPP 127
                   |||| ...||.|:..:|:|. ....|.|..|..|.|.|.|   ||....|......|.
 Worm    62 -------LNGN-SSHLAQSVNNMSIGARSTPSAQPPNPYQPAGYPGA---PPQQLQQVQRQQTPQ 115

  Fly   128 PTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPKAATPGAA 192
            .......:..||..|.||........|:.||     ||.||:..:       |:||
 Worm   116 QFAAVPQSVQAPSATPAGPLQAMQQAPAPTP-----GIPQMNQGA-------HLPP--------- 159

  Fly   193 PGQP-----PIPAAGSTSQPPLPGQPPLPGQP-PFSGQIPTSQPAP----SPYGVPSSRPGQPQL 247
              ||     |.|.     :|.:||.|...|.| .|....||||...    .|...||:.||.||:
 Worm   160 --QPHQIHQPTPL-----RPQIPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAYPGAPQV 217

  Fly   248 PPGATPPTYTQP---GLPPQQQQ--GIPPLQQPGIPQQQPGFP---PQQPGLPPLSQPG--LPPQ 302
            |  ..|.::..|   |.||.|..  ..||  .|.:|...|..|   ||.||:|....||  .|..
 Worm   218 P--QAPNSFIPPGTGGFPPGQPTAGSFPP--GPQVPGSYPSGPADIPQGPGMPRAFPPGASAPVA 278

  Fly   303 PGAPYGA--PQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQ 365
            ||.| ||  |.|||  .|.||..|.|.||  |..||...:..|  |||.||.||
 Worm   279 PGMP-GAFPPGQGG--PGMPGSFPPGAPG--PGGPGMPGSFAP--GAPGPGGPG----------- 325

  Fly   366 QPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQAR--RLDPDQMP 428
                |||.      ||||.|...| |:||.|                    ||.|  ||||:.||
 Worm   326 ----GYPS------GGPGMPGMQG-GYPGGP--------------------PQQRQQRLDPNMMP 359

  Fly   429 NPIQVMIENQRLSGGPFVTNQPGL-LPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTA 492
            :.:||:.::.....|.|.|..|.. |||||:|.....||||.:|:|:||:||..|.|.|:||.:.
 Worm   360 SAVQVIDDDSSTRSGIFPTGYPNAELPPLVSTNSFAQDQGNCNPKFMRSTLYTAPQTNDILKASQ 424

  Fly   493 LPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVH 557
            :||.:.|||.|.:.|.|.|||:|:.|..|||||.|||||:.|.|:|.|.||.|:|..|...:.|.
 Worm   425 IPLAVVISPFASLTEYEKEPPVVDLGPQGPIRCQRCKAYICPFMEFQDGGRSFRCPFCHARTSVE 489

  Fly   558 QNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHL 622
            ..|:.||||||:|.|...||||.||.|:.:|||.||:|...|:.|||||:||||||.:.:|::.:
 Worm   490 DAYFAHLDHTGRRTDIEMRPELCLGAYDLVATKQYCKNGIAPKEPAFIFMIDVSYNAISNGMLPI 554

  Fly   623 LCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGF 687
            ||..::.:|::||.:.||.:|.:|:|..|::..|||::|.|  |.|:|:|:.||||.|:|::||.
 Worm   555 LCQNLEKVLRNLPRESGQLESSMRIGLATFDQAVHFFDISS--ASPKMLVMSDVQEPFVPMVDGL 617

  Fly   688 LCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAP 752
            |....|:...:.|.:.|||::|:.:|.|||||.|.:||||:|||.::.|||:::|::.||..:||
 Worm   618 LLPYNEALPGLRAALAEIPKLFSQSKTTETILQPVVQAGLDALKCADRAGKVILFSTVLPTYDAP 682

  Fly   753 GKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTG 817
            ||||:::||.||||||||..|.||..:|..||::||:.|.:||||:|.||:||:|||||:|.:||
 Worm   683 GKLKSKNDRSLLGTDKEKNALVPQEDSYTKLGEQCVKSGVTVDLFLFPNAFIDVATIGQLSAVTG 747

  Fly   818 GEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELAS 882
            |.:||:.||.||.||.|::.::.::||:.||||.:.|||||.||||..|.|.|:|.|:||:|||:
 Worm   748 GSIFKFQYFSADKDGVRMLNELERHVSKKIAFDCMARVRTSTGIRPITFTGSFYMENSTDLELAT 812

  Fly   883 IDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAM 947
            :|.:|:...||||||.|....: ::|.|:||||.:||||||||||.|.||.....|::..|.:|:
 Worm   813 LDESKAFITEIKHDDSLKDPAS-FIQTAVLYTSMTGQRRLRILNLCLPVTADYNQVYRLADPEAL 876

  Fly   948 MLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLL 1012
            ..|..|||.....:....:::::|..|.||.||.||:.|:.....|||||||.|||:|||.:.:|
 Worm   877 TAFMLKQAVQLNRDKGSSEMRESLSSRCAQFLATYREKCSEGAPLGQLILPESLKLMPLYVNSIL 941

  Fly  1013 KNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIH----NVVPEETDLPTPVRCTHE 1073
            |||||||||:||:||:.:.::.|..:.....:..:|||.:||.    |...|..|||.|||.:.|
 Worm   942 KNDAISGGSEMTVDDKVWQMELIRGLRTENVMPLIYPRVMPISDLQINDTEEMKDLPKPVRASSE 1006

  Fly  1074 KTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPE-----TPLAKRIHG 1133
            ..:...|||::|||.||||:|.|....:||.||||....||..|. ..:||     :...:|...
 Worm  1007 FLENSKAYIIDNGVILFVWVGSACPQTWVQDVFGVGATNQIDTES-GTIPEKDNGHSRALRRAIQ 1070

  Fly  1134 ILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            :|.:.::||..::.:    :...||...:.|||||:....:.||||:|..:|::|:||:|
 Worm  1071 LLPRGIRERKTFVVV----EKSGLEPWMKKFLVEDKAGPANMSYVDYLVDIHRKIRDLIS 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	70/223 (31%)
		COG5028	395..1190	CDD:227361	364/806 (45%)
sec-24.1	NP_502178.1	PRK07764	<92..279	CDD:236090	66/221 (30%)
		COG5028	381..1123	CDD:227361	349/749 (47%)