Protein Alignment Sec24CD and Sec24AB

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: XP_314183.5
• Gene: Sec24AB / 1274981
• VectorBaseID: AGAMI1_007019
• Length: 1323
• Species: Anopheles gambiae
• Alignment Length: 1389
• Identity: 369/1389 - (26%)
• Similarity: 580/1389 - (41%)
• Gaps: 287/1389 - (20%)

  Fly    17 PQ-FGAP---PPNSGGWPPQQQQLPQQQPPQQQL----PPQQQQQQPQYG--------------- 58
            || :|.|   |..|.|..| |.|.||||..||||    .||.|.||...|
Mosquito     6 PQYYGIPNGFPHTSNGQSP-QYQYPQQQQQQQQLQQLQQPQSQDQQLYKGQSGDASNVSKGPTMP 69

  Fly    59 -APPPTSAASQ-------PY------------------------------LNGNYQQQLATSMGG 85
             .|||..|.||       |:                              |..|..|..||:.|.
Mosquito    70 NGPPPAIANSQLPPTTAKPFTAAGAAVAGGPPAAAAAFPIPSQGSAVPTQLRTNIVQNWATTNGN 134

  Fly    86 LSVGG-------GVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQ 143
            .:...       |..|..|:....|:.|||.|:.|...:         |.||.||.......|:.
Mosquito   135 STTSSRTSSPAFGSNGMPPVAVAAPRTAPALASEPARLY---------PTTNGNNNHNNNNLPSM 190

  Fly   144 AGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMP------PPKAATPGAAP--GQPPIPA 200
            |.|.:..  ||.:.||::.||       .||.:|....|      ...|..||||.  ..||..|
Mosquito   191 ASSQLQP--PPPAAPQTLPSG-------QATASGYNLSPNNNWSSAKMAQQPGAANLINTPPKSA 246

  Fly   201 AG-----STSQPPLPGQPPLPGQ------------------PPFSG-------------QIPTSQ 229
            :|     :.|.|.|.|...|.||                  ||..|             |.|..|
Mosquito   247 SGMSTPLNASTPTLTGPTILGGQQQSVQKLTASVQDLSLQRPPTMGVAAQAAGAGAATTQAPNQQ 311

  Fly   230 PAPSPYGVPSSRPGQPQL-------------------PPGATPPTYTQPGLPP--------QQQQ 267
            ...:|   |:...|.|.:                   |.||....|.|  .||        .|||
Mosquito   312 SQQAP---PTVNGGGPPVASTATTNGTMGAAAMFASHPAGAAGRGYGQ--APPPSSAQYQQMQQQ 371

  Fly   268 GIPPLQQPGIPQQQ-------PGFPPQQPGLPPLSQPGL------------PPQPGAPYGAPQQG 313
            ..|||:....||||       .|..|..||  ..:.|.|            ||..||..|:....
Mosquito   372 SQPPLKHTQQPQQQTAPSSMLQGPMPNGPG--STTNPSLQAAAAGMGKFNAPPPTGAALGSTMPT 434

  Fly   314 GYSGG---------FPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQQPMP 369
            ..|.|         :| :|......|||...|.|..:...:.|..     ||||.|.|  .||..
Mosquito   435 ALSAGQTPLNKRPMYP-RASAMVGAAPPSASGGQVPSQNPYTAMM-----QQPGAPVQ--TQPQH 491

  Fly   370 GYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGF---NQPPMPGAGNMYQQAPQARRLDP------- 424
            .:|.|..||.   ..|||.......|...|.:   .|..|.....|:||..|.::.|.
Mosquito   492 QFPSQQQQQF---QQPPQQQHQQNQQQFHPQYMQQQQQQMQPQQQMHQQQQQRQQYDQSKYQAGY 553

  Fly   425 -------DQMPNPIQV------------MIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSS 470
                   |...|.::.            :::|:.:.....||      ||.:.....:....|.:
Mosquito   554 DDGGYGRDYSRNVVRTGFNSLWGTNAVDLLQNRHVLPTDRVT------PPSIHLVNPLQSSANCN 612

  Fly   471 PRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPN 535
            |...|.:|..||.:..||:.:.|||.|.|.|...:.    ..|:::...:  :||..|:.|::|.
Mosquito   613 PDIFRCTLNKIPESSSLLQKSRLPLGLLIHPFRDLN----NLPVISCNTI--VRCKSCRTYINPF 671

  Fly   536 MQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPE 600
            :.|.|: :::||.:|..|:::.:. :|:...|....|...|||:...|.||:|..:|...  ||:
Mosquito   672 VFFSDS-KKWQCNLCYRTNDLPEE-FQYDPVTKTYGDPTRRPEIKSSTIEFIAPSEYMLR--PPQ 732

  Fly   601 VPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSL 665
            ...::|::|||....:||.::.:|:.:...|..||.|     ::.:||||.|||.:|||||....
Mosquito   733 PAIYLFLLDVSSLAQQSGYLYTVCNTLMEHLDSLPGD-----ARTQVGFIAYNSAIHFYNISEEY 792

  Fly   666 AQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEAL 730
            .||..:.|.||:::|:|..|..|.:.:....::..|::::|:.|..|.:|.:.|..|:|...:.:
Mosquito   793 NQPHEVTVLDVEDVFLPYPDNLLVNLKSCKELVKDLLKQLPKRFEHTHDTHSALGAALQVAYKLM 857

  Fly   731 KASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVD 795
            .||  .|::.||.:.|| ...||.|::|::.. ..:.||...|.|.|..|..|..||..|..:||
Mosquito   858 SAS--GGRVTVFQTCLP-NYGPGALQSRENPN-NRSSKEVAHLGPATDFYKRLALECSGQQIAVD 918

  Fly   796 LFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDG--KRLIQDIIKNVSRPIAFDAVMRVRTS 858
            :|:.|:.|.|||||..:|:.:||.:.....:......  |.|.:.:.:.::|.|.|:||||||.:
Mosquito   919 VFLLNSQYCDLATISGISKFSGGCMHHIPLYSESKPQLVKTLRKSLERYLTRKIGFEAVMRVRCT 983

  Fly   859 AGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLR 923
            .|:....|:|:||:.:|..:.|.:::......::|.:::.|...:.|..|.||||||...:||:|
Mosquito   984 RGLTIHTFHGNFFVRSTDLLSLPNVNPDAGFGMQITYEESLTKIKTVCFQAALLYTSSKAERRIR 1048

  Fly   924 ILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTS 988
            :..|.:.||.::::|....|...::...:|.|..:.:..|....:|..|:.:..|::.:|.....
Mosquito  1049 VHTLCIPVTESLSEVMYSADPQCIVGLLSKMAVDRSVTSSLSDARDAFINATVDIISAFRLVQNL 1113

  Fly   989 PTSAGQLILPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIP 1053
            ..::.:|::||.|:|||||...:||:.|...|:...||||.:.:..:.|:.|:|.:.|:||.|..
Mosquito  1114 AQTSSKLMVPENLRLLPLYILAMLKHPAFRTGTSTRLDDRVFAMSEMKSLPLDQLMRYIYPDFYL 1178

  Fly  1054 I---------------HNVVPEETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQ 1103
            :               |.:.|....|      :.||......::|:.|.::::::|..::...|.
Mosquito  1179 LDCLFVSGTGGYVDDGHKLEPPRLHL------SAEKLDSRSMFLLDCGPYMYIYIGSNVASSIVH 1237

  Fly  1104 SVFGVQGLQQIALERFNI-VP--ETPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFL 1165
            .:.|...:.:|  ..|.| :|  ||..::.:...|:.:.:|:.....:..:|...:..|......
Mosquito  1238 DILGYNSVAEI--PDFCIDLPSRETKASEALLNFLDIVNEEKPYTSYVQVIRDTSQFRSAMIEKF 1300

  Fly  1166 VEDRGTDGSASYVDFLCHMHKEIK 1189
            |:||..: |.||.:||.|:..::|
Mosquito  1301 VDDRNPN-SLSYYEFLQHLSTQVK 1323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	74/300 (25%)
		COG5028	395..1190	CDD:227361	226/844 (27%)
Sec24AB	XP_314183.5	None