DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and SEC24A

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_068817.1	Gene:	SEC24A / 10802	HGNCID:	10703	Length:	1093	Species:	Homo sapiens

Alignment Length:	1233	Identity:	344/1233 - (27%)
Similarity:	552/1233 - (44%)	Gaps:	216/1233 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSAASQPYLNGNYQQQLATSMGGLSV 88
            |.|||.|                    ...|.|.||   ..|:..||.||..|..|.:|...:|.
Human     7 PASGGAP--------------------ASLQAQNGA---ALASGSPYTNGPVQNALLSSQESVSQ 48

  Fly    89 GGGVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALP 153
            |...    .|....|...||....|.:|.:.:..:.....|.|.                    |
Human    49 GYNF----QLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNR--------------------P 89

  Fly   154 PSSTPQSVASGINQMSLNSATLAGLPHMPPPKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQ 218
            |      |||.....||:|..   .|.||.|.:..|...    |:|::....:..||  |||..|
Human    90 P------VASNPVTPSLHSGP---APRMPLPASQNPATT----PMPSSSFLPEANLP--PPLNWQ 139

  Fly   219 PPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGATPPTYT-QPGLPPQQQQGIPPLQQPGIPQQQP 282
                            |..||:.......|..::.||.: ...|....|     ....|.|..|.
Human   140 ----------------YNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQ-----YVSSGYPSLQN 183

  Fly   283 GFPPQQPGLPPLSQPGLPP--QPGAPYGAPQQGGYSGGFPGQA----PGGFPGAPPPL------- 334
            .|....|.:|||..|.||.  |||||:|.|..||..   |.:|    ...:...|.||
Human   184 SFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPP---PVRALTPLTSSYRDVPQPLFNSAVNQ 245

  Fly   335 ---------------------PGQQAAAPPQFGAPQP------GYPGQQPGYPPQPGQQPMPGY- 371
                                 .|....|.||.....|      ||     .||..|     |||
Human   246 EGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGY-----SYPSLP-----PGYQ 300

  Fly   372 ---PPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQV 433
               ||      |..|.||. ...:|..|  ..|.|.|: || |....:.....|.|:.: ..:.:
Human   301 NTTPP------GATGVPPS-SLNYPSGP--QAFTQTPL-GA-NHLTTSMSGLSLQPEGL-RVVNL 353

  Fly   434 MIENQRLSGGPFVTNQPGLLPPLVTTKFVVHD---QGNSSPRFLRSSLYCIPNTGDLLKTTALPL 495
            :.|...|...|       |.||:..    :|:   :.|.:|...|.:|..||.|..||....|||
Human   354 LQERNMLPSTP-------LKPPVPN----LHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPL 407

  Fly   496 TLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNY 560
            .|.:.|...:    ::.|:|....:  :||..|:.|::|.:.|:|. ||::|.:|...::|.:.:
Human   408 GLLLHPFKDL----VQLPVVTSSTI--VRCRSCRTYINPFVSFLDQ-RRWKCNLCYRVNDVPEEF 465

  Fly   561 -YQHLDHTGQRV--DKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHL 622
             |..|    .||  :.|.|||:...|.||:|..:|...  ||:.|.::|:.|||:|.|::|.::.
Human   466 LYNPL----TRVYGEPHRRPEVQNATIEFMAPSEYMLR--PPQPPVYLFVFDVSHNAVETGYLNS 524

  Fly   623 LCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGF 687
            :|..:.:.|..||     ..::.::||||::||:|||.::.||:||||::|.|::::|:|:.:..
Human   525 VCQSLLDNLDLLP-----GNTRTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENL 584

  Fly   688 LCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAP 752
            |.:..||..::..|::.:|:||..|.||::.|.||:||..:.:  |...|::.||.:.||.. ..
Human   585 LVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLM--SPTGGRMSVFQTQLPTL-GV 646

  Fly   753 GKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTG 817
            |.||.|::.....:.|: ..:||.|..|..|..:|..|..:||||:.:..|.|||::|.:||.:.
Human   647 GALKPREEPNHRSSAKD-IHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSA 710

  Fly   818 GEVFKYTYFQAD---VDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVE 879
            |.|:.|..:...   |..::|.:::.:.::|.|.|:||||:|.:.|:....|:|:||:.:|..:.
Human   711 GSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLS 775

  Fly   880 LASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDL 944
            |.:::.....::::..::.|...:.|..|.||||||..|:||:|:..|.|.|.:|:.|||...|:
Human   776 LPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADV 840

  Fly   945 DAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYAS 1009
            .|:....|..|..:.|..|....:|.|::.....|:.||....|....| |::|..|:|.||:..
Human   841 QAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPG-LMVPFSLRLFPLFVL 904

  Fly  1010 CLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYL----YPRFIPIHNVVPE------ETDL 1064
            .|||..:...|::..||:|.    |.:....||.:.||    :|....:.|:..|      :..:
Human   905 ALLKQKSFQTGTNARLDERI----FAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTI 965

  Fly  1065 PTP--VRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPE--T 1125
            |.|  ::.:.||...|||::::.|..|.:|:|:..:.:|:..|.|||....|. :....:||  |
Human   966 PQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIP-QPMTDLPELDT 1029

  Fly  1126 PLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEI 1188
            |.:.||...:..:.::|..:..:..:|....:::.|...::||| |:.:.||.:||.|:.:::
Human  1030 PESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDR-TESALSYYEFLLHIQQQV 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	243/817 (30%)
		zf-Sec23_Sec24	522..559	CDD:282641	12/36 (33%)
		Sec24-like	599..847	CDD:238756	82/250 (33%)
		Sec23_BS	848..932	CDD:285301	28/83 (34%)
		Sec23_helical	950..1043	CDD:282646	26/92 (28%)
		Gelsolin	1061..1135	CDD:279020	23/77 (30%)
SEC24A	NP_068817.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..168		33/158 (21%)
		THEG4	<92..158	CDD:292462	22/90 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..226		18/39 (46%)
		COG5028	237..1093	CDD:227361	265/917 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..328		14/47 (30%)
		zf-Sec23_Sec24	428..464	CDD:282641	12/38 (32%)
		Zinc finger-like	431..455		9/24 (38%)
		Sec24-like	501..743	CDD:238756	82/250 (33%)
		Sec23_BS	744..828	CDD:285301	28/83 (34%)
		Sec23_helical	843..938	CDD:282646	27/99 (27%)
		Gelsolin	964..1039	CDD:279020	23/75 (31%)
		Gelsolin-like. /evidence=ECO:0000255	966..1038		23/72 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820