Protein Alignment Sec24CD and SEC24B

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: NP_001287742.1
• Gene: SEC24B / 10427
• HGNCID: 10704
• Length: 1298
• Species: Homo sapiens
• Alignment Length: 1323
• Identity: 368/1323 - (27%)
• Similarity: 567/1323 - (42%)
• Gaps: 243/1323 - (18%)

  Fly     7 GPPPTQFQQQPQFG-------APPPNSGGWPPQQQQLPQQQP-----------PQQQLPPQQQQQ 53
            ||...|.|....:|       ||..:....|.:...||....           |.|.:.|....|
Human    76 GPAQNQMQVPSGYGLHHQNYIAPSGHYSQGPGKMTSLPLDTQCGDYYSALYTVPTQNVTPNTVNQ 140

  Fly    54 QP----QYGAPPPT----------------------SAASQPYLN--GNY-------------QQ 77
            ||    .|...||.                      ::|||||.:  .:|             .|
Human   141 QPGAQQLYSRGPPAPHIVGSTLGSFQGAASSASHLHTSASQPYSSFVNHYNSPAMYSASSSVASQ 205

  Fly    78 QLATSMGGLSVGGGVGGANP--LKPPLPQGAPAAAAPPPTGFNQFNSNAAPP--PTNNN-----N 133
            ...::.|..::......|.|  ..|.||.|        .|....|.|..||.  |..:|     |
Human   206 GFPSTCGHYAMSTVSNAAYPSVSYPSLPAG--------DTYGQMFTSQNAPTVRPVKDNSFSGQN 262

  Fly   134 AAFGAPPPTQAGSYVNGALPPSST----PQSVASGINQMSLNSATLAGLP----HMPPPKAATPG 190
            .|...|.|          |||..:    .|...||.:.::.:|   .|||    ::......:..
Human   263 TAISHPSP----------LPPLPSQQHHQQQSLSGYSTLTWSS---PGLPSTQDNLIRNHTGSLA 314

  Fly   191 AAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGATPP- 254
            .|...|.|..|.|.|.|.:....|           |.|.|..|.....||.....:.||.|..|
Human   315 VANNNPTITVADSLSCPVMQNVQP-----------PKSSPVVSTVLSGSSGSSSTRTPPTANHPV 368

  Fly   255 ----TYTQPGLPPQQQQGI--------------PPLQQPGIPQQQPGFPPQQPGLPPLS-QPGLP 300
                :.|||. ...||:|:              .||......:::.. ..::.|:...| .....
Human   369 EPVTSVTQPS-ELLQQKGVQYGEYVNNQASSAPTPLSSTSDDEEEEE-EDEEAGVDSSSTTSSAS 431

  Fly   301 PQPGAPYGAPQQGGYSGGFPGQAPGGFPG-APPPLPGQQAAAPPQFGAPQP-------------- 350
            |.|.: |.|.:.|.|.......|....|. ||.|.|   |:||....||.|
Human   432 PMPNS-YDALEGGSYPDMLSSSASSPAPDPAPEPDP---ASAPAPASAPAPVVPQPSKMAKPFGY 492

  Fly   351 GYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQ 415
            |||..||||  |....|:..     |.|...|.|     :||...|..||.||......|...|.
Human   493 GYPTLQPGY--QNATAPLIS-----GVQPSNPVY-----SGFQQYPQYPGVNQLSSSIGGLSLQS 545

  Fly   416 APQARRLDPDQMPNPIQVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYC 480
            :||...|      .|:.:..|...|...|.....|.|...|        .:.|.||...|.:|..
Human   546 SPQPESL------RPVNLTQERNILPMTPVWAPVPNLNADL--------KKLNCSPDSFRCTLTN 596

  Fly   481 IPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRF 545
            ||.|..||....|||.|.:.|...:    .:.|::....:  :||..|:.|::|.:.|:|. ||:
Human   597 IPQTQALLNKAKLPLGLLLHPFRDL----TQLPVITSNTI--VRCRSCRTYINPFVSFIDQ-RRW 654

  Fly   546 QCLMCKVTSEVHQNY-YQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIID 609
            :|.:|...::|.:.: |..|  |....:.|:|||:...|.||:|:.||...  ||:...::|::|
Human   655 KCNLCYRVNDVPEEFMYNPL--TRSYGEPHKRPEVQNSTVEFIASSDYMLR--PPQPAVYLFVLD 715

  Fly   610 VSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVG 674
            ||:|.|::|.:.:||..:...|..||.|     |:.|:||:|::||:||||::..|:||||::|.
Human   716 VSHNAVEAGYLTILCQSLLENLDKLPGD-----SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVS 775

  Fly   675 DVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKL 739
            |:.::|:|..|..|.:..||..:|..|:..:|.||.:|:||.:.|.||:||..:.:  |...|::
Human   776 DIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLM--SPTGGRV 838

  Fly   740 LVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYI 804
            .||.:.||...| |.|::|:|.....:.|....|.|.|..|..|..:|..|..:||||:.::.|.
Human   839 SVFQTQLPSLGA-GLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYS 902

  Fly   805 DLATIGQVSRLTGGEVFKYTYF-------QADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIR 862
            |||::..:|:.:.|.::.|..|       ||:    :|.:|:.:.::|.|.|:||||:|.:.|:.
Human   903 DLASLACMSKYSAGCIYYYPSFHYTHNPSQAE----KLQKDLKRYLTRKIGFEAVMRIRCTKGLS 963

  Fly   863 PTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNL 927
            ...|:|:||:.:|..:.||:|:.....::::..::.|.....|..|.||||||..|:||:|:..|
Human   964 MHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTL 1028

  Fly   928 ALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSA 992
            .|.|.:::|||:...|:.|.:...|..|..:.:..|....:|.|::.....|:.|.. ..|....
Human  1029 CLPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGS-TVSNLQH 1092

  Fly   993 GQLILPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNV 1057
            ..|:.|..|||.|||...|||..|...|:...||||.|.:..|.|..|...:..::|....|..:
Human  1093 SALMAPSSLKLFPLYVLALLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRL 1157

  Fly  1058 VPE------ETDLPTP--VRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQI 1114
            ..|      :..:|.|  .:.:.||...:||::::.|...::|:|:....:|::.|.|......|
Human  1158 TDEGAVHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASI 1222

  Fly  1115 ALERFNIVPETPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESV--------------FRHFL 1165
            . ::...:||          |:.:..||:|.. |||||.:..|..:              |:| |
Human  1223 P-QKMTHLPE----------LDTLSSERARSF-ITWLRDSRPLSPILHIVKDESPAKAEFFQH-L 1274

  Fly  1166 VEDRGTDGSASYVDFLCHMHKEI 1188
            :||| |:.:.||.:||.|:.::|
Human  1275 IEDR-TEAAFSYYEFLLHVQQQI 1296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	54/236 (23%)
		COG5028	395..1190	CDD:227361	253/824 (31%)
SEC24B	NP_001287742.1	COG5028	584..1289	CDD:227361	232/742 (31%)