Protein Alignment Sec24CD and sec24d

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: XP_002934294.1
• Gene: sec24d / 100494048
• XenbaseID: XB-GENE-977055
• Length: 1024
• Species: Xenopus tropicalis
• Alignment Length: 1095
• Identity: 478/1095 - (43%)
• Similarity: 656/1095 - (59%)
• Gaps: 104/1095 - (9%)

  Fly   125 APPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPKAATP 189
            ||||.:.:....|..||    .|                             |.|.|.||.|...
 Frog     8 APPPFSQSQPGLGGYPP----GY-----------------------------GSPMMSPPYANYG 39

  Fly   190 GAAPGQPPIP-----AAGSTSQPPL--PGQPPLPGQ--PPFSGQIPTSQPAPSPYGVPSSRPGQP 245
            |.:|..|..|     |....|||||  |...|...|  |.|||.|     .|..:|.|:......
 Frog    40 GTSPTNPTQPAMLKSAVSFGSQPPLNTPTSAPNNSQNGPNFSGNI-----MPRVHGPPAPNNTSF 99

  Fly   246 QLPPGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAP 310
            ..||...||::|...:|....|....|....|....|         |..|...:||.|..|
 Frog   100 SYPPYGHPPSHTNSTVPTPVHQVTNQLNNMQIGNYGP---------PSSSSSQIPPGPPMP---- 151

  Fly   311 QQGGYSGGFPGQA------PGGFPGAPPPLPGQQAAAPP----QFGAPQPGYPGQQPGYPPQPGQ 365
                  ..:|||.      ||  |..||||...|...|.    |.|..|.|..|.| .:..|...
 Frog   152 ------AAYPGQTRPMPVPPG--PYFPPPLSNNQNGLPSEPFLQTGNMQEGIAGHQ-NFLSQNQA 207

  Fly   366 QPMPGYPPQPGQQLGG--PGYP-PQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQM 427
            ||..||||......||  ||.. ..||| |||       |||.|.|        |..|:.|||.:
 Frog   208 QPQIGYPPPNSNNYGGQLPGSTLSYPGA-FPG-------NQPQMSG--------PPQRKTDPDSI 256

  Fly   428 PNPIQVMIENQRL--SGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKT 490
            |:|||| |::.::  :|..:.||..|.:||||||:..:.||||:|||::|.:.||.|.:.|:.|.
 Frog   257 PSPIQV-IDSDKINRAGQVYTTNVRGQVPPLVTTECTIQDQGNASPRYIRCTTYCFPTSSDMAKQ 320

  Fly   491 TALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSE 555
            :.:||.:.|.|||.|.:.|....|||.||.||||||||||||.|.|||::.|||:.|..|...::
 Frog   321 SQIPLAVVIKPLAVVPKNETPIYIVNHGETGPIRCNRCKAYMCPFMQFIEGGRRYHCGFCSCVND 385

  Fly   556 VHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLV 620
            |...|:|||||.|:|||..|||||.||:||::||.||||.|.||..||:||:||||||.:|:|:|
 Frog   386 VPPFYFQHLDHIGRRVDHFERPELSLGSYEYVATLDYCRKNKPPNPPAYIFMIDVSYNNIKNGVV 450

  Fly   621 HLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLD 685
            .|:|.::|.:|::||.::..:.|.:||||:|||..:||||:.|:|||||||||.|..|:|:||||
 Frog   451 RLICEELKILLENLPREENAESSAIRVGFVTYNKVLHFYNVNSNLAQPQMMVVTDTAEVFLPLLD 515

  Fly   686 GFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAE 750
            |||.:..||.:||:.|:.:||.|||||.|:||:..|.||||:||||||...|||.:|.|:||.||
 Frog   516 GFLVNFNESKSVINNLLSQIPEMFADTNESETVFAPIIQAGMEALKASECVGKLFIFQSSLPTAE 580

  Fly   751 APGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRL 815
            |||||:|||||||:.|:|||.:..||:..|..|.:|||..||.||||:|.|.:||:|::|.|:..
 Frog   581 APGKLRNRDDRKLVNTEKEKILFMPQSNVYENLAKECVANGCCVDLFLFPNQHIDVASMGIVTMQ 645

  Fly   816 TGGEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVEL 880
            |||.::||:.||...||::.|.|:.|::.:.:.|||:||||||.|.|.|:|:|..:||||:|||:
 Frog   646 TGGTLYKYSQFQVHTDGQQFISDLRKDIEKHVGFDAIMRVRTSTGFRATDFFGGIYMSNTSDVEM 710

  Fly   881 ASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLD 945
            |.:|..|::::|.||||||:.:....:|.||||||.||||||.|.|::|..::.:||::|.|:.|
 Frog   711 AGVDCDKAVTVEFKHDDKLSEDTGALIQCALLYTSISGQRRLLIHNISLNCSSQMADIYKSCETD 775

  Fly   946 AMMLFFAKQACFKLMEHSP-KQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYAS 1009
            .::.||||.| :|.|.|.| |.|:|.||.::|.:||||||:|.||::..|||||:.:||||:|.:
 Frog   776 VLINFFAKSA-YKAMLHHPLKTVRDVLISQTAHMLACYRKNCASPSAVSQLILPDSMKLLPVYMN 839

  Fly  1010 CLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEK 1074
            |||||:.:.|..::..|:|::..|.::.||:..|..:.||:.:|||.:..::..:||||||:.|:
 Frog   840 CLLKNEVLIGSPEVPTDERTFQRQLVMCMDVASSQIFFYPQLLPIHTMDLKDDTIPTPVRCSEER 904

  Fly  1075 TQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNI-VPETPLAKRIHGILEQI 1138
            ..|.|.::|.||:::|:|||....|:|:|.:|.|.....|..|..:: ..::..:|::..|::.|
 Frog   905 LSEGGIFLLANGINMFLWLGFNSPPEFIQGIFNVPSFAHITPEATSLPAVDSAHSKKLRSIMDAI 969

  Fly  1139 MKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLS 1193
            .|.....|::..::|.||.|..||..||||:|..|.|||:||||.:||||:.||:
 Frog   970 QKTCPYSMKLILVKQKDKAEMGFRQMLVEDKGLLGGASYMDFLCCVHKEIRQLLT 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	51/204 (25%)
		COG5028	395..1190	CDD:227361	390/798 (49%)
sec24d	XP_002934294.1	Med15	<35..>258	CDD:312941	83/265 (31%)
		COG5028	157..1020	CDD:227361	422/883 (48%)