Protein Alignment Sec24CD and sec24b

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: XP_002939332.3
• Gene: sec24b / 100493346
• XenbaseID: XB-GENE-1007271
• Length: 1103
• Species: Xenopus tropicalis
• Alignment Length: 1241
• Identity: 331/1241 - (26%)
• Similarity: 524/1241 - (42%)
• Gaps: 228/1241 - (18%)

  Fly    33 QQQLPQQQP-----------------PQQQLPPQQQ-----------------QQQPQYG----- 58
            |..:||.||                 |...:|..|:                 |..|.:.
 Frog     4 QNSMPQHQPSLVNTNHLSHKFYHNPSPGHDIPASQKTAEGVGLSATQGPPGVLQPYPAFSGDYSY 68

  Fly    59 APPPTSAASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFNQ---- 119
            |..|.:::..|....||..::::::.....               .||.....|..|.:.|
 Frog    69 ASYPANSSYTPQGLPNYSDRISSTVSSQHY---------------SGAQYTNLPASTQYGQVIYS 118

  Fly   120 FNSNAAPPPTN--NNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGIN---------QMSLNSA 173
            .|.:|....||  .|..|.|.|.........:.|.|..:..|..|..::         |.::|||
 Frog   119 HNVHAVAQVTNTVQNVHASGPPSLLHQDLKRHNAAPLPTVEQHGAQDVHMQNYGVSFGQQNINSA 183

  Fly   174 TLAGLPHMPPPKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSG-QIPTSQPAPSPYGV 237
                  |         ..|.||.|.|.| .||...|.......|. .|.| ......|.||....
 Frog   184 ------H---------SVADGQSPRPEA-KTSPVSLHHSALQEGM-QFGGYNHANCAPTPSSSSS 231

  Fly   238 PSSRPGQPQLPPGATPPTYTQPGLPPQQQQGIPP--LQQPGIPQQQPGFPPQQPGLPPLSQPGLP 300
            ........:.....:..|.:...|.|:....:..  ..:|......|.|      |.|:||..
 Frog   232 DDEEEEDDEEAGFESSSTTSTASLEPKNYDVLEGGCYTEPSSTTSTPAF------LNPVSQSS-- 288

  Fly   301 PQPGAPYGAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQ 365
             :...|:|                   .|.|...||.|.||||...: |...|..:|.|     |
 Frog   289 -KQTKPFG-------------------HGYPTLQPGYQNAAPPSHSS-QSSTPVHRPSY-----Q 327

  Fly   366 QPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNP 430
            |....|                           .|.||.|....|...|||.|      .:.|.|
 Frog   328 QYNSNY---------------------------SGLNQLPASLGGLSLQQAQQ------PEGPRP 359

  Fly   431 IQVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPL 495
            :.::.:...|.    |.|.|..:|.|.:..    .:.|.:|...||:|..||.|..||....|||
 Frog   360 VNLIQDRNLLP----VLNVPAPIPNLNSDL----KRLNCNPNSFRSTLTNIPQTQALLNKAKLPL 416

  Fly   496 TLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNY 560
            .|.|.|.      ..:|.|........:||..|:.|::|.:.|:|. ||::|.:|...::|.:.:
 Frog   417 GLLIHPF------RSKPRIPVLSPSTIVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVPEEF 474

  Fly   561 -YQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLC 624
             |..:  |....:.|:|||:...:.||:|:.||.....||.|  ::|::|||||.|:||.:.:..
 Frog   475 MYNPV--TRSYGEPHKRPEVQNASVEFIASSDYMLRPPPPAV--YLFVLDVSYNAVESGYLKVFS 535

  Fly   625 SQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLC 689
            ..:.:.|..|..|     |:.::||||::|||||||::..|:||||::|.|::::|:|..||.|.
 Frog   536 QSLLDNLDKLRGD-----SRTKIGFITFDSTVHFYNLQEGLSQPQMLIVTDIEDVFLPTPDGLLV 595

  Fly   690 HPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGK 754
            :..||..:|..|:..:|.|||:||||.:.|.||:|...:.:  |:..|::.||.:.||...| |.
 Frog   596 NMHESKELIKDLLTALPSMFANTKETHSALGPALQGAFKLM--SSTGGRISVFQTQLPSIGA-GL 657

  Fly   755 LKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGE 819
            |::|:|.....:.|....|.|.|..|..|..:|..|..:||||:.::.|.|||::..:|:.:.|.
 Frog   658 LQSREDPNQRSSTKGVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGC 722

  Fly   820 VFKY-----TYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVE 879
            |:.|     |:..|..:  :|.:|:...::|.|.|:||||:|.:.|:....|:|:.|:.:|..:.
 Frog   723 VYYYPMYHHTHNSAQTE--KLKKDLDHYLTRKIGFEAVMRIRCTKGLSIHTFHGNLFVRSTDLLS 785

  Fly   880 LASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDL 944
            ||:|:.....::::..::.|........||||||||..||||:||..|.|.|..::.|||...|:
 Frog   786 LANINEDAGFAVQMSIEESLTDTSLACFQVALLYTSHKGQRRIRIHTLCLPVVNSLPDVFAGADV 850

  Fly   945 DAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYAS 1009
            .|:....|..|..:.:..|....:|.|::.....||.|.. ..|......||.|..|::..||..
 Frog   851 QAVTCLLANMAVDRSVSSSLSDARDALVNAVVDSLASYNS-TLSNLQQSTLISPNALRMFALYIL 914

  Fly  1010 CLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPE------ETDLPTP- 1067
            .|||..|...|:...||||.:.:..:....:...:..::|....|..:..|      ::.:|.|
 Frog   915 ALLKQKAFRTGTSTRLDDRVFAMCQMKCQPVVHLMKMIHPNLYRIDRLTDEGAILVNDSVVPQPP 979

  Fly  1068 -VRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPETPLAKRI 1131
             ...:.||...:||:::::|..|::|:|:..|..|:..|.|.|....:. ::...:|:
 Frog   980 LQSLSAEKLSREGAFLMDSGSSLYIWIGRNCSNTFLSDVLGFQNYASVP-QKLACLPD------- 1036

  Fly  1132 HGILEQIMKERSRYMRITWLRQNDKLESV--------------FRHFLVEDRGTDGSASYVDFLC 1182
               |.....||.|.. |:||:::..|..|              |:| |:||| |:.:.||.:||.
 Frog  1037 ---LNTTASERLRNF-ISWLKEDSPLNPVLHVIKDDSAAKTDFFQH-LIEDR-TEAAFSYYEFLL 1095

  Fly  1183 HMHKEI 1188
            |:.:::
 Frog  1096 HIQQQV 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	45/219 (21%)
		COG5028	395..1190	CDD:227361	251/822 (31%)
sec24b	XP_002939332.3	COG5028	278..1094	CDD:227361	272/926 (29%)