Protein Alignment Sec24CD and sec24a

DIOPT Version :10

• Sequence 1: NP_001259918.1
• Gene: Sec24CD / 33409
• FlyBaseID: FBgn0262126
• Length: 1231
• Species: Drosophila melanogaster
• Sequence 2: XP_002935946.2
• Gene: sec24a / 100488463
• XenbaseID: XB-GENE-987688
• Length: 1116
• Species: Xenopus tropicalis
• Alignment Length: 1226
• Identity: 347/1226 - (28%)
• Similarity: 557/1226 - (45%)
• Gaps: 174/1226 - (14%)

  Fly     2 NPNMYGPPPTQFQQQPQFGAPPPNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSAA 66
            ||.||.||   ...|......|   |.:|.|......|.|...|......|..||.|........
 Frog    24 NPLMYSPP---LASQGYHSLLP---GSYPQQMPAKTAQHPGHGQQNSSVPQTVPQLGGLQTVHQL 82

  Fly    67 SQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTNN 131
            |.|.   |:.|.....:.|.::.....|..|:..|...||.:...|||      .::|..|.|..
 Frog    83 SGPQ---NFPQLPNYPVSGQTINRPPMGHTPVTSPQHTGARSRMPPPP------QNSAGEPATAV 138

  Fly   132 NNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPKA----ATPGAA 192
            :||:.|..||.....|.       .||.|.|                  .|.|.|    ::.|..
 Frog   139 SNASQGNVPPQSNWQYF-------PTPLSHA------------------QPQPFANHIYSSAGPT 178

  Fly   193 PGQPPIPAAGSTSQPPLP-------GQPPLPGQPPFSGQIPTSQPAPSPYGV-PSSRPGQ----P 245
            .||   |::.|.|.||..       |.|||.......|..|.|||.....|. |:|.|.:    |
 Frog   179 SGQ---PSSQSNSVPPTTHQYAASFGGPPLQNSFMNQGPPPMSQPGRPTLGAHPTSSPSRSLAPP 240

  Fly   246 QLPPGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGL--PPLSQPGLPPQPGAPYG 308
            ..|||:|        |||      ||||..         ||:..|:  ||.|...|...    |.
 Frog   241 PGPPGST--------LPP------PPLQSA---------PPKPDGISAPPGSDSSLHNN----YD 278

  Fly   309 APQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYP---PQPGQQPMPG 370
            ..:.|||.|..       .|..||..|.|........|:   .||...|||.   |..|    ||
 Frog   279 TIEGGGYMGMV-------HPAQPPLPPSQNPQITRNVGS---AYPTLPPGYQNVFPASG----PG 329

  Fly   371 YPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPM----PGAGNMYQQAPQARRLDPDQMPNPI 431
            ..|.|.|      ||.:|      ||    ..||.:    ...|::..|  |.::||..:..|.:
 Frog   330 LAPAPQQ------YPNRP------QP----ITQPSINDLASSVGSLSLQ--QTQQLDGLRALNLL 376

  Fly   432 QVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLT 496
            |   |...|...|.....|.|...:        .:.|.:|...|.:|..||.|..||....|||.
 Frog   377 Q---ERNILPATPLKAPIPCLQEDI--------QKLNCNPELFRCTLTNIPQTQALLNKAKLPLG 430

  Fly   497 LNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNY- 560
            |.:.|...:.    :.|:|....:  :||..|:.|::|.:.|:|. ||::|.:|...::|.:.:
 Frog   431 LLLHPFKDLS----QLPVVTSSTI--VRCRSCRTYINPFVSFLDQ-RRWKCNLCYRVNDVPEEFM 488

  Fly   561 YQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCS 625
            |..:  |....:.|:|||:...|.||:|..:|...  ||:.|.::|:.|||:|.:::|.::.:|.
 Frog   489 YNPV--TRAYGEPHKRPEVQNATIEFMAPSEYMLR--PPQPPVYLFMFDVSHNAIETGYLNTVCQ 549

  Fly   626 QIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCH 690
            .:.:.|..||     ..::.::||||::||:|||:::..|:||||:||.|:.::|:|:.:..|.:
 Frog   550 TLLDNLDWLP-----GNTRTKIGFITFDSTIHFYSLQEGLSQPQMLVVSDIDDVFIPMPENLLVN 609

  Fly   691 PEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKL 755
            ..|...::..|::.:|:||..:.||::.|.||:||..:.  .|...|::.||.:.||...| |.|
 Frog   610 LNECKELVQDLLKNLPQMFTKSSETQSALGPALQAAYKL--TSPTGGRISVFQTQLPSLGA-GAL 671

  Fly   756 KNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEV 820
            |.|::.....:.||...|||.|..|..|..:|..|..:||||:.:..|.|||::|.:||.:.|.|
 Frog   672 KPREEPNQKSSAKEIHNLTPATDFYKKLALDCSGQQIAVDLFLLSGRYSDLASLGCISRYSAGSV 736

  Fly   821 F---KYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELAS 882
            :   .|.|....|..::|.:::.:.::|.|.|:||||:|.:.|:....|:|:||:.:|..:.|.:
 Frog   737 YYYRAYHYQHNPVQVEKLQKELKRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPN 801

  Fly   883 IDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAM 947
            ::.....::::..::.|.....|..|.||||||..|:||:|:..:.|.|.:.::|::...|:.|:
 Frog   802 VNPDAGYAVQMSVEENLTDTPVVSFQSALLYTSSKGERRIRVHTMCLPVASALSDIYAGADVQAV 866

  Fly   948 MLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLL 1012
            ....|..|..:.:..|....:|.|::.:...|:.:|....:....| |:.|..|:|||::...||
 Frog   867 TGLLANMAVDRSITSSLSDARDALVNAAIDSLSAFRSSVLTVQQPG-LLAPYSLRLLPMFVLALL 930

  Fly  1013 KNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPE------ETDLPTP--VR 1069
            |..|...|::.:||:|.:.:..|.:..|...:..::.....:.|:..|      :..:|.|  ::
 Frog   931 KQKAFQTGTNASLDERIFSMCQIKNQPLLHLMLMIHSNLYRVDNLTDEGALNINDRTIPQPPILQ 995

  Fly  1070 CTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPETPLAKRIHGI 1134
            .:.||...||||:::.|..|.:|:|:....:|...|.||.....:.|| .|.:||...|:....|
 Frog   996 LSVEKLNRDGAYLMDAGSILILWVGRNCGQNFFTQVLGVPNYGSMPLE-MNQLPELDTAESARAI 1059

  Fly  1135 --LEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEI 1188
              :..:.::|..:..:..:|....|:|.|...::||| |:.:.||.:||.|:.:::
 Frog  1060 AFISWLREQRPFFPTLHIIRDESPLKSAFLQNMIEDR-TESALSYYEFLLHLQQQV 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	PRK12323	<119..321	CDD:481241	61/219 (28%)
		COG5028	395..1190	CDD:227361	234/812 (29%)
sec24a	XP_002935946.2	Atrophin-1	<12..>234	CDD:460830	67/252 (27%)
		COG5028	288..1116	CDD:227361	255/892 (29%)