DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec24CD and sec24a

DIOPT Version :9

Sequence 1:	NP_001259918.1	Gene:	Sec24CD / 33409	FlyBaseID:	FBgn0262126	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	XP_001340708.3	Gene:	sec24a / 100000526	ZFINID:	ZDB-GENE-120926-1	Length:	1097	Species:	Danio rerio

Alignment Length:	1237	Identity:	340/1237 - (27%)
Similarity:	541/1237 - (43%)	Gaps:	220/1237 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNPNMYGPP--PTQFQQQPQFGAPPPNSGGWPPQQQQLPQQQPPQQQLP-PQQQQQQPQYGAPPP 62
            :||....||  |......|..|.|   :|..........|..|.....| |.....:|....||.
Zfish    28 LNPGFMAPPLQPGYISSVPAKGLP---AGPQSCYNTHRHQPSPVGTHSPLPASPNHRPVLPGPPQ 89

  Fly    63 TSAASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAAPP 127
            .|....|:.|.:||.                    .:.|....:.||.         |.|.||||
Zfish    90 ASPTPPPHANSHYQH--------------------TQQPSSWSSTAAV---------FQSTAAPP 125

  Fly   128 PTN--NNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPKAATPG 190
            ..|  ..:..||.||....|:      ||.:.|....:                  |||.||.|
Zfish   126 ALNVMAPHQTFGPPPAAMRGT------PPLTVPPPTVA------------------PPPFAAAP- 165

  Fly   191 AAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGAT--P 253
                 ||     ||..|           |||:...|.|..||.|:..         .||.:|  |
Zfish   166 -----PP-----STIAP-----------PPFAAAPPPSTIAPPPFAA---------APPPSTIAP 200

  Fly   254 PTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAPQQGGYSGG 318
            |.:.  ..||......||.         .|.||....||| .:.|:|| |.|....|
Zfish   201 PPFV--AAPPPSTIAPPPF---------AGAPPTSTVLPP-PRAGVPP-PSASAAVP-------- 244

  Fly   319 FPGQAPGGFPGAPPPLPGQQAAAPPQFG-APQP---GYPGQQPGYPPQPGQQPMPGYPPQPGQQL 379
                        |||......|.|...| ..:|   |||..||||      ....||.|..||..
Zfish   245 ------------PPPTGAHSDAGPYHLGQMSRPVGSGYPSLQPGY------STAQGYTPPVGQIQ 291

  Fly   380 GGPGYPPQPGAGFPGQPGRPGFNQP----PMPGAGNMY---QQAPQARR--LDP--------DQM 427
            ..||..         ||...|...|    |.|.||..:   |..|.|::  |.|        ...
Zfish   292 HPPGQI---------QPSSMGQIHPTAQIPPPSAGQFHPAGQIPPSAQQAGLSPSLAALSLQSHT 347

  Fly   428 PNPIQV--MIENQRLSGGPFVTNQPGLLPPLVTTKFVVHD--QGNSSPRFLRSSLYCIPNTGDLL 488
            |..::|  :::.:.|.....||      |||   ..:..|  :.|.||...|.:|..||.|..||
Zfish   348 PEALRVLNLLQERNLLPHTAVT------PPL---PCLPQDLQRMNCSPEVFRCTLTSIPQTQALL 403

  Fly   489 KTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVT 553
            ....|||.|.:.|...:.    :.|:|....:  :||..|:.|::|.:.|| ...|::|.:|...
Zfish   404 NKAKLPLGLLLHPFKDLS----QLPVVTSSNI--VRCRSCRTYINPFVTFV-GPTRWKCNLCHRI 461

  Fly   554 SEVHQNYYQHLDHTGQRVDK-----HERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYN 613
            :||.:.:..:      .|.|     |:|||:...|.||:|..:|...  ||:...::|::|||:|
Zfish   462 NEVPEEFMYN------PVSKSYGAPHKRPEVQNATIEFIAPSEYMLR--PPQPAVYLFVLDVSHN 518

  Fly   614 TVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQE 678
            .|::|.:..:|..:.:.|..||.|     ::.::||||::||:|||:::..|::|||::|.|:.:
Zfish   519 AVETGYLDAVCRSLLDNLSSLPGD-----ARTKIGFITFDSTIHFYSLQEGLSRPQMLIVSDIDD 578

  Fly   679 MFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFN 743
            :|:|..||.|.:..|...::..|:..:|:|:..|.||.:.|.||:||..:.|.|:  .|::.:|.
Zfish   579 VFLPTQDGLLVNLNECKELVQDLLSSLPQMWRQTMETHSALGPALQAAFKLLSAT--GGRISLFQ 641

  Fly   744 STLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLAT 808
            :.||.. ..|.||.|:........|:...|:|.|..|..|..:|..|..:||||:.:..|.||::
Zfish   642 TQLPTL-GIGALKPREQPSTKTQAKDIQHLSPATDFYKKLALDCSGQHVAVDLFLLSAQYCDLSS 705

  Fly   809 IGQVSRLTGGEVFKYTYFQA---DVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHF 870
            :|.:||.:.|.||.|..:..   ....:|..:|:.:.::|.|.|:||||:|.:.|:....|:|:|
Zfish   706 LGCISRYSAGSVFYYPSYHTLHNPAQAERFQKDLKRYLTRKIGFEAVMRIRCTKGLSIHTFHGNF 770

  Fly   871 FMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTI 935
            |:.:|..:.||:::.....::::..::.|...:.|..|.||||||..|:||:|:..|.|.|..::
Zfish   771 FVRSTDLLSLANVNPDAGFAVQMNIEENLLDLQTVSFQAALLYTSSKGERRIRVHTLCLPVVNSL 835

  Fly   936 ADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPEC 1000
            :|:|...|:.|:....|..|..:.:..|....:|.|::.:..:|:.||....:....| |:.|.|
Zfish   836 SDIFAGADVQAITALLASMAVDRSVTASVSDARDALVNAAVDMLSSYRSSVLTVPQPG-LLAPAC 899

  Fly  1001 LKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPE----- 1060
            |:|.|||...|||:.|....|...||:|.:.:..:....|..::..::|....:.::..|
Zfish   900 LRLFPLYILALLKHKAFGTSSATRLDERMFCMCQLKQQPLAYAMLSIHPSLYRVDDLTDEGALNV 964

  Fly  1061 -ETDLPTP--VRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIV 1122
             :..:|.|  .:.:.||...|.|::::.|..|::|:|:..:|.|:..|.||.|...|.|....:
Zfish   965 NDCTIPQPRVQQLSVEKLSRDAAFLMDCGSVLYLWIGRNCNPAFLTQVLGVDGYANIPLNMTQL- 1028

  Fly  1123 PETPLAK--RIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMH 1185
            ||...|:  |:...::.:.:.|..:..:..:|....|::.|...::||| ::.:.||.:||.|:.
Zfish  1029 PELDTAESCRMRAFVDWLRERRPFHPLLHVIRDESPLKAEFLQLMIEDR-SESALSYYEFLLHLQ 1092

  Fly  1186 KE 1187
            ::
Zfish  1093 QQ 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec24CD	NP_001259918.1	COG5028	395..1190	CDD:227361	240/832 (29%)
		zf-Sec23_Sec24	522..559	CDD:282641	12/36 (33%)
		Sec24-like	599..847	CDD:238756	80/250 (32%)
		Sec23_BS	848..932	CDD:285301	29/83 (35%)
		Sec23_helical	950..1043	CDD:282646	26/92 (28%)
		Gelsolin	1061..1135	CDD:279020	22/77 (29%)
sec24a	XP_001340708.3	COG5028	256..1088	CDD:227361	254/881 (29%)
		zf-Sec23_Sec24	431..467	CDD:282641	12/38 (32%)
		Sec24-like	504..747	CDD:238756	80/250 (32%)
		Sec23_BS	748..832	CDD:285301	29/83 (35%)
		Sec23_helical	847..941	CDD:282646	26/94 (28%)
		Gelsolin	968..1035	CDD:279020	20/67 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53542
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920