DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Send1 and PRSS36

DIOPT Version :9

Sequence 1:	NP_608662.1	Gene:	Send1 / 33407	FlyBaseID:	FBgn0031406	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	293	Identity:	90/293 - (30%)
Similarity:	128/293 - (43%)	Gaps:	70/293 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HLLL-AVHLLISPVVPVLL-------------------EPSERIIGGSSMDITDVPWQVSLQYYG 51
            |||| .|.|:|||:.....                   |||.||:|||:......||||||.:.|
Human     4 HLLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGG 68

  Fly    52 EHFCGGSIYSKTIIITAAHCI-------KEGERSIRAGSSLHDSGGVVVG-----VEAYIIHPQF 104
            .|.||||:.:.:.:::||||.       ...|.|:..|  :|...|.:.|     |.|.::...:
Human    69 GHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLG--VHSQDGPLDGAHTRAVAAIVVPANY 131

  Fly   105 DKHNMENDVAVLKLSSPLSFSDSIQTI--PLAETDPPTSSSALATGWG---RGNFLIRPRQLQGV 164
            .:..:..|:|:|:|:||.|...::..:  |.|.......::..|||||   ..:.|..|..||.|
Human   132 SQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEV 196

  Fly   165 EILIRPLIVCKLKYGN-GVFNED-------ICAG--RMGKGGCYGDSGGPLVF--NGQ--LVGIT 215
            |:.:.....|:..|.. |.||..       :|||  ...:..|.||||||||.  .|:  ..|||
Human   197 ELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGIT 261

  Fly   216 S---------RTGNIVCLGSSLYASVARYRNWI 239
            |         |.|        ::.:||.|..||
Human   262 SFGFGCGRRNRPG--------VFTAVATYEAWI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Send1	NP_608662.1	Tryp_SPc	29..239	CDD:214473	76/249 (31%)
Send1	NP_608662.1	Tryp_SPc	30..239	CDD:238113	75/248 (30%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	76/249 (31%)
		Tryp_SPc	47..289	CDD:238113	77/250 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940