Protein Alignment Ser12 and PRSS8

DIOPT Version :10

• Sequence 1: NP_523456.1
• Gene: Ser12 / 33406
• FlyBaseID: FBgn0011832
• Length: 245
• Species: Drosophila melanogaster
• Sequence 2: NP_002764.1
• Gene: PRSS8 / 5652
• HGNCID: 9491
• Length: 343
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 80/277 - (28%)
• Similarity: 130/277 - (46%)
• Gaps: 38/277 - (13%)

  Fly     2 LLHWLVLVASVTLISAGSSP------ERIVGGHPVLISEVPWQAALMYSEKYICGAVIYSDKIII 60
            :|.:|.|:.|.|......:|      .||.||...:..:.|||.::.|...::||..:.|::.::
Human    17 ILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVL 81

  Fly    61 TAAHCV-ERPFDTLYSVRVGSVWKNLGGQHARVAVIR---KHEDYVSSTILFNDIAVIRLVDTLI 121
            :||||. .......|.|::|:...:...:.|:|:.::   .|..|:..... .|||:::|...:.
Human    82 SAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQ-GDIALLQLSRPIT 145

  Fly   122 FNAEVRPIQLADSAPAA------GTEASVSGWGEI--GILWLQPTSLLKTSVKILDPNVCKRSY- 177
            |:..:|||.|    |||      |...:|:|||.:  .:..|.|..|.:..|.::....|...|
Human   146 FSRYIRPICL----PAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYN 206

  Fly   178 --------QYITKTMICAAALL--KDSCHGDSGGPL---VSG-GQLVGIVSYGIGCANPFFPGVY 228
                    .::.:.|:||..:.  ||:|.|||||||   |.| ..|.||||:|..|.....||||
Human   207 IDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVY 271

  Fly   229 ANVAELKPWILNAIEQL 245
            ...:....||.:.:.:|
Human   272 TLASSYASWIQSKVTEL 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser12	NP_523456.1	Tryp_SPc	23..238	CDD:214473	71/241 (29%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	72/243 (30%)