Protein Alignment Ser12 and PRSS2

DIOPT Version :10

• Sequence 1: NP_523456.1
• Gene: Ser12 / 33406
• FlyBaseID: FBgn0011832
• Length: 245
• Species: Drosophila melanogaster
• Sequence 2: NP_001290343.1
• Gene: PRSS2 / 5645
• HGNCID: 9483
• Length: 261
• Species: Homo sapiens
• Alignment Length: 261
• Identity: 93/261 - (35%)
• Similarity: 132/261 - (50%)
• Gaps: 32/261 - (12%)

  Fly     8 LVASVTLISAG-SSP----ERIVGGHPVLISEVPWQAALMYSEKYICGAVIYSDKIIITAAHCVE 67
            |:..:|.::|. ::|    ::||||:....:.||:|.:| .|..:.||..:.|::.:::|.||.:
Human     3 LLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSL-NSGYHFCGGSLISEQWVVSAGHCYK 66

  Fly    68 RPFDTLYS----------VRVGSVWKNL-----GGQHARVAVIRKHEDYVSSTILFNDIAVIRLV 117
            ...::..|          ||:|.  .|:     ..|....|.|.:|..|.|.| |.|||.:|:|.
Human    67 SAINSKLSGRGCEYHRIQVRLGE--HNIEVLEGNEQFINAAKIIRHPKYNSRT-LDNDILLIKLS 128

  Fly   118 DTLIFNAEVRPIQLADSAPAAGTEASVSGWGEI---GILWLQPTSLLKTSVKILDPNVCKRSYQ- 178
            ...:.|:.|..|.|..:.||||||:.:||||..   |..:  |..|......:|....|:.||.
Human   129 SPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADY--PDELQCLDAPVLSQAECEASYPG 191

  Fly   179 YITKTMICAAALL--KDSCHGDSGGPLVSGGQLVGIVSYGIGCANPFFPGVYANVAELKPWILNA 241
            .||..|.|...|.  ||||.||||||:||.|:|.||||:|.|||....||||..|.....||.:.
Human   192 KITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDT 256

  Fly   242 I 242
            |
Human   257 I 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser12	NP_523456.1	Tryp_SPc	23..238	CDD:214473	86/235 (37%)
PRSS2	NP_001290343.1	Tryp_SPc	24..256	CDD:238113	88/237 (37%)