DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser12 and PRSS1

DIOPT Version :9

Sequence 1:	NP_523456.1	Gene:	Ser12 / 33406	FlyBaseID:	FBgn0011832	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	246	Identity:	88/246 - (35%)
Similarity:	120/246 - (48%)	Gaps:	18/246 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLVASVTLISAGSSPERIVGGHPVLISEVPWQAALMYSEKYICGAVIYSDKIIITAAHCVERPF 70
            |..||: .|.:.....::||||:....:.||:|.:| .|..:.||..:.:::.:::|.||    :
Human   232 LTFVAA-ALAAPFDDDDKIVGGYNCEENSVPYQVSL-NSGYHFCGGSLINEQWVVSAGHC----Y 290

  Fly    71 DTLYSVRVGSVWKNL-----GGQHARVAVIRKHEDYVSSTILFNDIAVIRLVDTLIFNAEVRPIQ 130
            .:...||:|.  .|:     ..|....|.|.:|..|...| |.|||.:|:|....:.||.|..|.
Human   291 KSRIQVRLGE--HNIEVLEGNEQFINAAKIIRHPQYDRKT-LNNDIMLIKLSSRAVINARVSTIS 352

  Fly   131 LADSAPAAGTEASVSGWGEIGILWLQ-PTSLLKTSVKILDPNVCKRSYQ-YITKTMICAAALL-- 191
            |..:.||.||:..:||||........ |..|......:|....|:.||. .||..|.|...|.
Human   353 LPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGG 417

  Fly   192 KDSCHGDSGGPLVSGGQLVGIVSYGIGCANPFFPGVYANVAELKPWILNAI 242
            ||||.||||||:|..|||.|:||:|.|||....||||..|.....||.|.|
Human   418 KDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTI 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser12	NP_523456.1	Tryp_SPc	23..238	CDD:214473	80/223 (36%)
Ser12	NP_523456.1	Tryp_SPc	24..238	CDD:238113	80/222 (36%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	80/223 (36%)
		Tryp_SPc	249..467	CDD:238113	82/225 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8646
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820