DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4267 and PNLIPRP2

DIOPT Version :9

Sequence 1:	NP_001259919.1	Gene:	CG4267 / 33405	FlyBaseID:	FBgn0264979	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_005387.3	Gene:	PNLIPRP2 / 5408	HGNCID:	9157	Length:	469	Species:	Homo sapiens

Alignment Length:	282	Identity:	82/282 - (29%)
Similarity:	135/282 - (47%)	Gaps:	44/282 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LIPFTSSRGKMQFILFKRDFADCGRELFVG-DVENLRNSGFDARHQTRIVIHGWMSQSKGSHIRK 125
            |:|::......:|:|:..:..: ..:|..| :.:.:..|.|....:||.:|||::.:::.|....
Human    44 LLPWSPEDIDTRFLLYTNENPN-NFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSD 107

  Fly   126 VKNAYLSLTDPGPNGEPAPYEDFNVIVCDWSKTSTNVNYYEVAKTVEDMGALLAELVRYLNQEAN 190
            :......:            |..|.|..|| :..:...|.:..:.:..:||..|.|::.|:.:..
Human   108 MCKKMFEV------------EKVNCICVDW-RHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLG 159

  Fly   191 MHYDDVYVIGHSLGAQIAGSAGKQIMPYRFNTIYALDPAGPQFREKSDEYRIDASDASYVESIQT 255
            ...:||:||||||||..|..||:: :..|...|..||||||.|:::.:|.|:|.|||.:|:.|.|
Human   160 YSLEDVHVIGHSLGAHTAAEAGRR-LGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHT 223

  Fly   256 -------SVSFGFEQPVGHATFYPNYGKNQKKC--------------------YVYGCSHKRSHD 293
                   |:.||..|.|||..|:||.||....|                    :| .|:|.||.:
Human   224 DSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFV-SCNHLRSFE 287

  Fly   294 YFIESLTSPAGFWGPRCERHDD 315
            |:..|:.:|.||.|..|..:|:
Human   288 YYSSSVLNPDGFLGYPCASYDE 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4267	NP_001259919.1	Lipase	64..351	CDD:278576	81/280 (29%)
CG4267	NP_001259919.1	Pancreat_lipase_like	71..347	CDD:238363	80/273 (29%)
PNLIPRP2	NP_005387.3	Lipase	18..354	CDD:395099	82/282 (29%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	93..105		4/11 (36%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	257..279		1/22 (5%)
		PLAT_PL	357..469	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940