DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4267 and Lpl

DIOPT Version :9

Sequence 1:	NP_001259919.1	Gene:	CG4267 / 33405	FlyBaseID:	FBgn0264979	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_036730.1	Gene:	Lpl / 24539	RGDID:	3017	Length:	474	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	105/362 - (29%)
Similarity:	151/362 - (41%)	Gaps:	84/362 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LGVDPSFWKKFFKHLIPFTSSRGKMQFILFKRDFAD-----------------CGRELFVGDVEN 95
            |||    |      |...|:.||.:......|||:|                 |  .|..|..::
  Rat    11 LGV----W------LQSLTAFRGGVAAADGGRDFSDIESKFALRTPEDTAEDTC--HLIPGLADS 63

  Fly    96 LRNSGFDARHQTRIVIHGWMSQSKGSHIRKVKNAYLSLTDPGPNGEPAPYE---DFNVIVCDWSK 157
            :.|..|:...:|.:|||||          .|...|.|..   |....|.|:   |.||||.||..
  Rat    64 VSNCHFNHSSKTFVVIHGW----------TVTGMYESWV---PKLVAALYKREPDSNVIVVDWLY 115

  Fly   158 TSTNVNYYEV-AKTVEDMGALLAELVRYLNQEANMHYDDVYVIGHSLGAQIAGSAGKQIMPYRFN 221
            .:.  .:|.| |...:.:|..:|..:.:|.:|.|...|:|:::|:||||..||.|| .:...:.|
  Rat   116 RAQ--QHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAG-SLTNKKVN 177

  Fly   222 TIYALDPAGPQFREKSDEYRIDASDASYVESIQTSV------SFGFEQPVGHATFYPNYGKNQKK 280
            .|..||||||.|.......|:...||.:|:.:.|..      |.|.::||||...|||.|..|..
  Rat   178 RITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPG 242

  Fly   281 CYV------------------YGCSHKRSHDYFIESL---TSPAGFWGPRC---ERHDDGTWLLL 321
            |.:                  ..|||:||...||:||   .:|:..:  ||   |..:.|..|..
  Rat   243 CNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAY--RCNSKEAFEKGLCLSC 305

  Fly   322 MSDGEFRMGGEPS---IPKNGTFYVKTYSKPPYAMGH 355
            ..:....:|.|.:   ..::...|:||.|:.||.:.|
  Rat   306 RKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFH 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4267	NP_001259919.1	Lipase	64..351	CDD:278576	97/340 (29%)
CG4267	NP_001259919.1	Pancreat_lipase_like	71..347	CDD:238363	93/329 (28%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		4/20 (20%)
		lipo_lipase	33..472	CDD:132274	96/330 (29%)
		Pancreat_lipase_like	37..334	CDD:238363	89/316 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		1/22 (5%)
		PLAT_LPL	341..465	CDD:238856	1/2 (50%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940