DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sau and GOLPH3

DIOPT Version :9

Sequence 1:	NP_001014460.1	Gene:	sau / 33402	FlyBaseID:	FBgn0267378	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_071413.1	Gene:	GOLPH3 / 64083	HGNCID:	15452	Length:	298	Species:	Homo sapiens

Alignment Length:	296	Identity:	210/296 - (70%)
Similarity:	244/296 - (82%)	Gaps:	8/296 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSDGLVRRSVKPRENGG----AEGGLNANTPDDNQDALDNLKDQEDNIDDGDSKETRLTLMEEVL 63
            ||.|||:|..:...|..    |.||...::.||.|    :.:|::|:.|.|||||||||||||||
Human     7 RSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQ----SRRDEQDDDDKGDSKETRLTLMEEVL 67

  Fly    64 LLGLKDKEGYTSFWNDCISSGLRGCILIELGLRGRVMIEKSGMRRRGLCTRKLILKSDQQTGDVL 128
            ||||||:||||||||||||||||||:||||.||||:.:|..||||:.|.|||:|.|||..|||||
Human    68 LLGLKDREGYTSFWNDCISSGLRGCMLIELALRGRLQLEACGMRRKSLLTRKVICKSDAPTGDVL 132

  Fly   129 LDEALKHIKETDPPETVQSWIEYLSGETWNPLKLRYQLKNVRERLAKNLVEKGVLTTEKQNFLLF 193
            |||||||:|||.||||||:|||.|||||||||||.|||:||||||||||||||||||||||||||
Human   133 LDEALKHVKETQPPETVQNWIELLSGETWNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLF 197

  Fly   194 DMTTHPLSDNVVKCRLVKKIQDSVLSKWVNDPQRMDKRMLALIFLAHASDVIENAFAPLNDDDYE 258
            |||||||::|.:|.||:||:|::||.||||||.|||:|:||||:|||||||:|||||||.|:.|:
Human   198 DMTTHPLTNNNIKQRLIKKVQEAVLDKWVNDPHRMDRRLLALIYLAHASDVLENAFAPLLDEQYD 262

  Fly   259 VAMKRVRELLDLDFEAESAKPNANEILWAVFMAFTK 294
            :|.||||:|||||.|.|..|.|.||:||||..||||
Human   263 LATKRVRQLLDLDPEVECLKANTNEVLWAVVAAFTK 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sau	NP_001014460.1	GPP34	58..267	CDD:283397	166/208 (80%)
GOLPH3	NP_071413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		19/53 (36%)
		GPP34	62..271	CDD:399028	166/208 (80%)
		Beta-hairpin required for oligomerization. /evidence=ECO:0000250	190..201		10/10 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160093
Domainoid	1	1.000	353	1.000	Domainoid score	I1010
eggNOG	1	0.900	-	-		E1_KOG3983
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56942
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1811
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51992
OrthoDB	1	1.010	-	-		D1117244at2759
OrthoFinder	1	1.000	-	-		FOG0002388
OrthoInspector	1	1.000	-	-		oto90308
orthoMCL	1	0.900	-	-		OOG6_103565
Panther	1	1.100	-	-	O	PTHR12704
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1661
SonicParanoid	1	1.000	-	-		X1581
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800