Protein Alignment APLP2 and Aplp2

DIOPT Version :10

• Sequence 1: NP_001633.1
• Gene: APLP2 / 334
• HGNCID: 598
• Length: 763
• Species: Homo sapiens
• Sequence 2: NP_037038.1
• Gene: Aplp2 / 64312
• RGDID: 2128
• Length: 765
• Species: Rattus norvegicus
• Alignment Length: 767
• Identity: 712/767 - (92%)
• Similarity: 736/767 - (95%)
• Gaps: 6/767 - (0%)

Human     1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNI 65
            |||||||||||||:||:|||:||||||.|||||||||||||||||||||||||||||||||||||
  Rat     1 MAATGTAAAAATGKLLVLLLLGLTAPAAALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNI 65

Human    66 QTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTP 130
            |||||||||||||||..|||||||||||:||||||||||||||.|:||:|||||||||:|..|.|
  Rat    66 QTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKKQCRSHIVIP 130

Human   131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQF 195
            |||||||||||||||||.|||||:|||||||.||.|||||||||||:||||||||||||||||||
  Rat   131 FKCLVGEFVSDVLLVPENCQFFHQERMEVCEKHQRWHTVVKEACLTEGMTLYSYGMLLPCGVDQF 195

Human   196 HGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDED--- 257
            ||||||||||||::.|.|...:|  |||||||||||||.:.|||||||||||||||||.|||
  Rat   196 HGTEYVCCPQTKVVDSDSTMSKE--EEEEEEEDEEEDYALDKSEFPTEADLEDFTEAAADEDEDE 258

Human   258 -DEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRA 321
             :|:||||||||||||||||:||||||||||||||.||||:|||||.||||||||||||||||||
  Rat   259 EEEEEEEGEEVVEDRDYYYDSFKGDDYNEENPTEPSSDGTISDKEIAHDVKAVCSQEAMTGPCRA 323

Human   322 VMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNE 386
            ||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
  Rat   324 VMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKTMIPPTPLPTNDVDVYFETSADDNE 388

Human   387 HARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQ 451
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   389 HARFQKAKEQLEIRHRSRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQ 453

Human   452 LVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLA 516
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   454 LVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLA 518

Human   517 VDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISE 581
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat   519 VDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTSSISE 583

Human   582 TPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSK 646
            .||||||||||||||||||||||||:|.||||||||||||||||||:.|||||||||||||||||
  Rat   584 NPVDVRVSSEESEEIPPFHPFHPFPSLSENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVINSK 648

Human   647 NKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVI 711
            ||:||||||||||||||||||||||||||||.:||||||||||||||||||||||||||||||||
  Rat   649 NKMDENMVIDETLDVKEMIFNAERVGGLEEEPDSVGPLREDFSLSSSALIGLLVIAVAIATVIVI 713

Human   712 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763
            ||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   714 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APLP2	NP_001633.1	A4_EXTRA	42..204	CDD:128326	146/161 (91%)
		GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	46..139		82/92 (89%)
		CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	147..205		52/57 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..299		71/91 (78%)
		Kunitz_ABPP-like	309..360	CDD:438650	50/50 (100%)
		APP_E2	365..547	CDD:463752	179/181 (99%)
		JMTM_APLP2	680..760	CDD:411992	79/79 (100%)
		Interaction with DAB2. /evidence=ECO:0000250	749..763		13/13 (100%)
		NPXY motif	750..755		4/4 (100%)
Aplp2	NP_037038.1	A4_EXTRA	42..204	CDD:128326	146/161 (91%)
		GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	46..139		82/92 (89%)
		CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	147..205		52/57 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..301		71/91 (78%)
		Kunitz_ABPP-like	311..362	CDD:438650	50/50 (100%)
		APP_E2	367..549	CDD:463752	179/181 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..616		16/18 (89%)
		JMTM_APLP2	682..762	CDD:411992	79/79 (100%)
		Interaction with DAB2. /evidence=ECO:0000250	751..765		13/13 (100%)
		NPXY motif	752..757		4/4 (100%)