DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APLP2 and Aplp2

DIOPT Version :9

Sequence 1:	NP_001633.1	Gene:	APLP2 / 334	HGNCID:	598	Length:	763	Species:	Homo sapiens
Sequence 2:	NP_037038.1	Gene:	Aplp2 / 64312	RGDID:	2128	Length:	765	Species:	Rattus norvegicus

Alignment Length:	767	Identity:	712/767 - (92%)
Similarity:	736/767 - (95%)	Gaps:	6/767 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNI 65
            |||||||||||||:||:|||:||||||.|||||||||||||||||||||||||||||||||||||
  Rat     1 MAATGTAAAAATGKLLVLLLLGLTAPAAALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNI 65

Human    66 QTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTP 130
            |||||||||||||||..|||||||||||:||||||||||||||.|:||:|||||||||:|..|.|
  Rat    66 QTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKKQCRSHIVIP 130

Human   131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQF 195
            |||||||||||||||||.|||||:|||||||.||.|||||||||||:||||||||||||||||||
  Rat   131 FKCLVGEFVSDVLLVPENCQFFHQERMEVCEKHQRWHTVVKEACLTEGMTLYSYGMLLPCGVDQF 195

Human   196 HGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDED--- 257
            ||||||||||||::.|.|...:|  |||||||||||||.:.|||||||||||||||||.|||
  Rat   196 HGTEYVCCPQTKVVDSDSTMSKE--EEEEEEEDEEEDYALDKSEFPTEADLEDFTEAAADEDEDE 258

Human   258 -DEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRA 321
             :|:||||||||||||||||:||||||||||||||.||||:|||||.||||||||||||||||||
  Rat   259 EEEEEEEGEEVVEDRDYYYDSFKGDDYNEENPTEPSSDGTISDKEIAHDVKAVCSQEAMTGPCRA 323

Human   322 VMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNE 386
            ||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
  Rat   324 VMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKTMIPPTPLPTNDVDVYFETSADDNE 388

Human   387 HARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQ 451
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   389 HARFQKAKEQLEIRHRSRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQ 453

Human   452 LVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLA 516
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   454 LVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLA 518

Human   517 VDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISE 581
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat   519 VDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTSSISE 583

Human   582 TPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSK 646
            .||||||||||||||||||||||||:|.||||||||||||||||||:.|||||||||||||||||
  Rat   584 NPVDVRVSSEESEEIPPFHPFHPFPSLSENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVINSK 648

Human   647 NKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVI 711
            ||:||||||||||||||||||||||||||||.:||||||||||||||||||||||||||||||||
  Rat   649 NKMDENMVIDETLDVKEMIFNAERVGGLEEEPDSVGPLREDFSLSSSALIGLLVIAVAIATVIVI 713

Human   712 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763
            ||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   714 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APLP2	NP_001633.1	A4_EXTRA	42..204	CDD:128326	146/161 (91%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	46..139		82/92 (89%)
		APP_N	49..147	CDD:280358	87/97 (90%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	147..205		52/57 (91%)
		APP_Cu_bd	149..204	CDD:289676	50/54 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..299		71/91 (78%)
		Kunitz_BPTI	309..361	CDD:278443	51/51 (100%)
		APP_E2	365..547	CDD:289677	179/181 (99%)
		APP_amyloid	709..759	CDD:287486	49/49 (100%)
		Interaction with DAB2. /evidence=ECO:0000250	749..763		13/13 (100%)
		NPXY motif	750..755		4/4 (100%)
Aplp2	NP_037038.1	A4_EXTRA	42..204	CDD:128326	146/161 (91%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	46..139		82/92 (89%)
		APP_N	49..147	CDD:280358	87/97 (90%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	147..205		52/57 (91%)
		APP_Cu_bd	149..204	CDD:289676	50/54 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..301		71/91 (78%)
		Kunitz_BPTI	311..363	CDD:278443	51/51 (100%)
		APP_E2	367..549	CDD:289677	179/181 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..616		16/18 (89%)
		APP_amyloid	711..761	CDD:287486	49/49 (100%)
		Interaction with DAB2. /evidence=ECO:0000250	751..765		13/13 (100%)
		NPXY motif	752..757		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83688687
Domainoid	1	1.000	359	1.000	Domainoid score	I12427
eggNOG	1	0.900	-	-		E1_KOG4295
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20396
Inparanoid	1	1.050	1440	1.000	Inparanoid score	I2977
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50020
OrthoDB	1	1.010	-	-		D101324at7742
OrthoFinder	1	1.000	-	-		FOG0001588
OrthoInspector	1	1.000	-	-		oto137847
orthoMCL	1	0.900	-	-		OOG6_104222
Panther	1	1.100	-	-	LDO	PTHR23103
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X996
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310