| Sequence 1: | NP_001633.1 | Gene: | APLP2 / 334 | HGNCID: | 598 | Length: | 763 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001344627.1 | Gene: | Aplp2 / 11804 | MGIID: | 88047 | Length: | 763 | Species: | Mus musculus |
| Alignment Length: | 763 | Identity: | 709/763 - (92%) |
|---|---|---|---|
| Similarity: | 736/763 - (96%) | Gaps: | 0/763 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNI 65
Human 66 QTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTP 130
Human 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQF 195
Human 196 HGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDED 260
Human 261 EEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPR 325
Human 326 WYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARF 390
Human 391 QKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVET 455
Human 456 HLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPE 520
Human 521 KAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVD 585
Human 586 VRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVD 650
Human 651 ENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVM 715
Human 716 LRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| APLP2 | NP_001633.1 | A4_EXTRA | 42..204 | CDD:128326 | 143/161 (89%) |
| GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 | 46..139 | 82/92 (89%) | |||
| APP_N | 49..147 | CDD:280358 | 87/97 (90%) | ||
| CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 | 147..205 | 49/57 (86%) | |||
| APP_Cu_bd | 149..204 | CDD:289676 | 48/54 (89%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 211..299 | 71/87 (82%) | |||
| Kunitz_BPTI | 309..361 | CDD:278443 | 51/51 (100%) | ||
| APP_E2 | 365..547 | CDD:289677 | 179/181 (99%) | ||
| APP_amyloid | 709..759 | CDD:287486 | 49/49 (100%) | ||
| Interaction with DAB2. /evidence=ECO:0000250 | 749..763 | 13/13 (100%) | |||
| NPXY motif | 750..755 | 4/4 (100%) | |||
| Aplp2 | NP_001344627.1 | A4_EXTRA | 42..204 | CDD:128326 | 143/161 (89%) |
| Kunitz_BPTI | 309..361 | CDD:278443 | 51/51 (100%) | ||
| APP_E2 | 365..547 | CDD:315580 | 179/181 (99%) | ||
| APP_amyloid | 709..759 | CDD:313694 | 49/49 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83965132 | |
| Domainoid | 1 | 1.000 | 359 | 1.000 | Domainoid score | I13015 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG4295 | |
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H20396 | |
| Inparanoid | 1 | 1.050 | 1180 | 1.000 | Inparanoid score | I4523 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S6881 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG50020 | |
| OrthoDB | 1 | 1.010 | - | - | D405630at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001588 | |
| OrthoInspector | 1 | 1.000 | - | - | oto121617 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104222 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR23103 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2378 |
| SonicParanoid | 1 | 1.000 | - | - | X996 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 19 | 19.250 | |||||